Attenuation of aortic baroreflex responses by microinjections of endomorphin-2 into the rostral ventrolateral medullary pressor area of the rat

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 289, Issue 1 58-1, 2005, Pages

  Kasamatsu, Ken ^a   Sapru, Hreday N ^a,b  

^a RWJ Barnabas Health   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Bradycardia; Depressor responses; Naloxonazine; Opioid peptides

Indexed keywords

ENDOMORPHIN 2; NALOXONAZINE; OPIATE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; AORTA NERVE; ARTICLE; ATTENUATION; BLOOD PRESSURE; BRADYCARDIA; CARDIOVASCULAR FUNCTION; DRUG MECHANISM; HEART RATE; HYPERPOLARIZATION; INHIBITION KINETICS; MALE; MEAN ARTERIAL PRESSURE; MEDULLA OBLONGATA; MICROINJECTION; MODULATION; MOLECULAR WEIGHT; NERVE STIMULATION; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RAT; RAT STRAIN; THALAMUS VENTRAL NUCLEUS;

ANIMALS; AORTA; BAROREFLEX; BLOOD PRESSURE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; HEART RATE; MALE; MEDULLA OBLONGATA; MICROINJECTIONS; NALOXONE; NERVOUS SYSTEM PHYSIOLOGY; OLIGOPEPTIDES; RATS; RATS, WISTAR; RECEPTORS, OPIOID, MU; VAGUS NERVE;

EID: 21044458457     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00007.2005     Document Type: Article

References (40)

1. Aicher SA and Randich A. Antinociception and cardiovascular responses produced by electrical stimulation in the nucleus tractus solitarius, nucleus reticularis ventralis and the caudal medulla. Pain 42: 103-119, 1990.
2. Aicher SA, Schreihoffer AM, Kraus JA, Sharma S, Milner TA, and Guyenet PG. Mu-opioid receptors are present in functionally identified sympathoexcitatory neurons in the rat rostral ventrolateral medulla. J Comp Neurol 433: 34-47, 2001.
3. Baraban SC, Stornetta RL, and Guyenet PG. Effects of morphine and morphine withdrawal on adrenergic neurons of the rat rostral ventrolateral medulla. Brain Res 676: 245-257, 1995.
4. Bradford HF, Crowder JM, and White EJ. Inhibitory actions of opioid compounds on calcium fluxes and neurotransmitter release from mammalian cerebral cortical slices. Br J Pharmacol 88: 87-93, 1986.
5. Brophy S, Ford TW, Carey M, and Jones JFX. Activity of aortic chemoreceptors in the anaesthetized rat. J Physiol 514.3: 821-828, 1999.
6. Brown DL and Guyenet PG. Electrophysiological study of cardiovascular neurons in the rostral ventrolateral medulla in rats. Circ Res 56: 359-369, 1985.
7. Cheng Z, Powley TL, Schwaber JS, and Doyle FJ. A laser confocal microscopic study of vagal afferent innervation of rat aortic arch: chemoreceptors as well as baroreceptors. J Auton Nerv Syst 67: 1-14, 1997.
8. Chu XP, Xu NS, Li P, and Wang JQ. Endomorphin-1 and endomorphin-2, endogenous ligands for the μ-opioid receptor, inhibit electrical activity of rat rostral ventrolateral medulla neurons in vitro. Neuroscience 93: 681-686, 1999.
9. Ding Y, Kaneko T, Nomura S, and Mizuno N. Immunohistochemical localization of μ-opioid receptors in the central nervous system of the rat. J Comp Neurol 367: 375-402, 1996.
10. Gonzalez ER, Krieger AJ, and Sapru HN. Central resetting of baroreflex in the spontaneously hypertensive rat. Hypertension 5: 346-352, 1983.
11. Gordon FJ. Opioids and the nucleus of the tractus solitarius; effects on cardiovascular and baroreflex function. In: Nucleus of the Solitary Tract, edited by Barraco IRA. Boca Raton, FL: CRC, 1994, p. 283-287.
12. Guyenet PG, Koshiya N, Huangfu D, Baraban SC, Stornetta RL, and Li YW. Role of medulla oblongata in generation of sympathetic and vagal outflows. Prog Brain Res 107: 127-414, 1996.
13. Guyenet PG, Stornetta RL, Schreihofer AM, Pelaez NM, Hayar A, Aicher S, and Llewellyn-Smith IJ. Opioid signalling in the rat rostral ventrolateral medulla. Clin Exp Pharmacol Physiol 29: 238-242, 2002.
14. Hackler L, Zadina JE, Ge LJ, and Kastin AJ. Isolation of relatively large amounts of endomorphin-1 and endomorphin-2 from human brain cortex. Peptides 18: 1635-1639, 1997.
15. Hayar A and Guyenet PG. Pre- and postsynaptic inhibitory actions of methionine-enkephalin on identified bulbospinal neurons of the rat RVL. J Neurophysiol 80: 2003-2014, 1998.
16. Kasamatsu K, Chitravanshi VC, and Sapru HN. Depressor and bradycardic responses to microinjections of endomorphin-2 into the nucleus tractus solitarius are mediated via ionotropic glutamate receptors. Am J Physiol Regul Integr Comp Physiol 287: R715-R728, 2004.
17. Kobayashi M, Cheng ZB, Tanaka K, and Nosaka S. Is the aortic depressor nerve involved in arterial chemoreflexes in rats? J Auton Nerv Syst 78:38-48, 1999.
18. Madden CJ and Sved A. Rostral ventrolateral medulla C1 neurons and cardiovascular regulation. Cell Mol Neurobiol 23: 739-749, 2003.
19. Martin-Schild S, Gerall AA, Kastin AJ, and Zadina JE. Differential distribution of endomorphin 1 and endomorphin 2-like immunoreactivities in the CNS of the rodent. J Comp Neurol 405: 450-471, 1999.
20. Milner TA, Drake CT, and Aicher SA. Cellular relations between μ-opioid receptive, GABAergic and reticulospinal neurons in the rostral ventrolateral medulla. Brain Res 917: 1-14, 2001.
21. Miyawaki T, Goodchild AK, and Pilowsky PM. Activation of μ-opioid receptors in rat ventrolateral medulla selectively blocks baroreceptor reflexes while activation of δ-opioid receptors blocks somato-sympathetic reflexes. Neuroscience 109: 133-144, 2002.
22. Morilak DA, Somogyi P, McIlhinney RA, and Chalmers J. An enkephalin-containing pathway from nucleus tractus solitarius to the pressor area of the rostral ventrolateral medulla of the rabbit. Neuroscience 31: 187-194, 1989.
23. Murugaian J, Sundaram K, Krieger AJ, and Sapru HN. Electrolytic lesions in the ventrolateral medullary depressor area abolish depressor responses to the electrical stimulation of the aortic nerve. Brain Res 499: 371-377, 1989.
24. Nicholson C. Diffusion from an injected volume of a substance in brain tissue with arbitrary volume fraction and tortuosity. Brain Res 333: 325-329, 1985.
25. Numao Y, Saito M, Terui N, and Kumada M. The aortic nerve-sympathetic reflex in the rat. J Auton Nerv Syst 13: 65-79, 1985.
26. Paxinos G and Watson C. The Rat Brain in Stereotaxic Coordinates (4th ed.). New York: Academic, 1998.
27. Pierce TL and Wessendorf MW. Immunocytochemical mapping of endomorphin-2 immuno-reactivity in rat brain. J Chem Neuroanat 18: 181-207, 2000.
28. 1-opioid receptor antagonist, naloxonazine, on cocaine-induced conditioned place preference and locomotor behavior in rats. Neurosci Lett 332: 159-162, 2002.
29. Sapru HN. Glutamate circuits in selected medullo-spinal areas regulating cardiovascular function. Clin Exp Pharmacol Physiol 29: 491-496, 2002.
30. Sapru HN and Krieger AJ. Carotid and aortic chemoreceptor function in the rat. J Appl Physiol 42: 344-348, 1977.
31. Sapru HN, Gonzalez ER, and Krieger AJ. Aortic nerve stimulation in the rat: cardiovascular and respiratory responses. Brain Res Bull 6: 393-398, 1981.
32. Sapru HN, Punnen S, and Willette RN. Role of enkephalins in ventrolateral medullary control of blood pressure. In: Brain Peptides and Catecholamines in Cardiovascular Regulation in Normal and Disease States, edited by Buckley JP, Ferrario C, and Lokhandwala MF. New York: Raven, 1987, p. 153-168.
33. Sapru HN and Chitravanshi VC. Responses to microinjections of endomorphins and nociceptin into the medullary cardiovascular areas. Clin Exp Pharmacol Physiol 29: 243-247, 2002.
34. Schoffelmeer ANM, Wardeh G, and Vanderschren LJMJ. Morphine acutely and persistently attenuates nonvesicular GABA release in rat nucleus accumbens. Synapse 42: 87-94, 2001.
35. Schreihofer AM and Guyenet PG. The baroreflex and beyond: control of sympathetic vasomotor tone by GABAergic neurons in the ventrolateral medulla. Clin Exp Pharmacol Physiol 29: 514-521, 2002.
36. Stornetta RL, McQuiston TJ, and Guyenet PG. GABAergic and glycinergic presympathetic neurons of rat medulla oblongata identified by retrograde transport of pseudorabies virus and in situ hybridization. J Comp Neurol 479: 257-270, 2004.
37. Sundaram K and Sapru HN. NMDA receptors in the intermediolateral column of the spinal cord mediate sympathoexcitatory responses elicited from the ventrolateral medullary pressor area. Brain Res 544: 33-41, 1991.
38. Wang Q and Li P. Inhibition of baroreflex following microinjection of GABA or morphine into the nucleus tractus solitarii of rabbit. J Auton Nerv Syst 25: 165-172, 1988.
39. Willette RN, Barcas PP, Krieger AJ, and Sapru HN. Vasopressor and depressor areas in the rat medulla: identification by L-glutamate microinjections. Neuropharmacology 22: 1071-1079, 1983.
40. Zadina JE, Hackler L, Ge LJ, and Kastin AJ. A potent and selective endogenous agonist for the μ-opiate receptor. Nature 386: 499-502, 1997.