A practical large-scale preparation of 5’-bromospiro(cyclohexane-1, 3-[3h]indol)-2’(1’h)-one

Organic Preparations and Procedures International

Volumn 37, Issue 3, 2005, Pages 283-285

  Wilk, Bogdan K ^a   Rubezhov, Arkadiy ^a   Helorn, Jean L ^a   Routel, Lisa R ^a   Potoski, John R ^a  

^a WYETH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LARGE SCALE PREPARATION;

5 BROMOSPIRO[CYCLOHEXANE 1,3' [3H]INDOL] 2'(1'H) ONE; INDOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; BROMINATION; CHEMICAL PROCEDURES; CHEMICAL REACTION; CHROMATOGRAPHY; CRYSTALLIZATION; REACTION ANALYSIS; SYNTHESIS;

EID: 21044435840     PISSN: 00304948     EISSN: 19455453     Source Type: Journal    
DOI: 10.1080/00304940509354961     Document Type: Article

References (14)

1. A. Fensome, R. H. W. Bender, J. Cohen, M. A. Collins, V. Mackner, L. L. Miller, J. W. Ullrich, R. Winneker, J. E. Wrobel, P. Zhang, Z. Zhang and Y. Zhu, Bioorg. Med. Chem. Lett., 12, 3487 (2002).
2. M. A. Collins, V. Hudak, R. Bender, A. Fensome, P. Zhang, L. Miller, R. C. Winneker, Z. Zhang, Y. Zhu, J. Cohen, R. J. Unwalla and J. Wrobel, Bioorg. Med. Chem. Lett., 14, 2185 (2004);
3. G. S. Grubb, L. Zhi, T. K. Jones, C. M. Tegley, A. Fensome, L. L. Miller, J. W. Ullrich, R. H. W. Bender, P. Zhang, J. E. Wrobel, J. P. Edwards, PCT Publication No. WO 00/66167; Chem. Abstr., 133, 350135 (2000).
4. A. S. Kende and J. C. Hodges, Synth. Commun., 12, 1 (1982).
5. R. F. Moore and S. G. P. Plant, J. Chem. Soc., 3475 (1951).
6. J. Wolff and M. Taddei, Tetrahedron, 42, 4267 (1986).
7. I. Fleming, M. A. Loreto and I. H. M. Wallace, J. Chem. Soc., Perkin Trans. 1, 349 (1986).
8. S. Lee and J. F. Hartwig, J. Org. Chem., 66, 3402 (2001).
9. H. R. Henze and C. M. Blair, J. Am. Chem. Soc., 55, 4621 (1933).
10. W. C. Sumpter, M. Miller and L. N. Hendrick, J. Am. Chem. Soc., 67, 1656 (1945).
11. I. Gruda, Can. J. Chem., 50, 18 (1972).
12. L. Sun, N. Tran, F. Tang, H. App, P. Hirth, G. McMahon and C. Tang, J. Med. Chem., 41, 2588 (1998).
13. C. Crestini and R. Saladino, Synth. Commun., 24, 2835 (1994).
14. A. Di Malta, L. Foulon, G. Garcia, D. Nisato, R. Roux, C. Serradeil-Legal, G. Valette and J. Wagnon, EP0636608 (1995); Chem. Abstr., 122, 213926 (1995).