Rapid measurement of modified oligonucleotide levels in plasma samples with a fluorophore specific for single-stranded DNA

Antisense and Nucleic Acid Drug Development

Volumn 7, Issue 3, 1997, Pages 133-140

  Gray, Gary D ^a   Wickstrom, Eric ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCENT DYE; METHYLPHOSPHONIC ACID; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; OLIGONUCLEOTIDE; OLIGORIBONUCLEOTIDE; PEPTIDE NUCLEIC ACID; SINGLE STRANDED DNA;

ANIMAL EXPERIMENT; ARTICLE; DNA DETERMINATION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DETERMINATION; FLUORESCENCE ANALYSIS; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; TUMOR;

ANIMALIA;

EID: 0030843081     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1997.7.133     Document Type: Article

References (8)

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2. AGRAWAL, S. (1996a). Antisense Therapeutics. (Humana Press, Totowa, NJ).
3. AGRAWAL, S. (1996b). Antisense oligonucleotides: toward clinical trials. Trends Biotechnol. 14, 376-387.
4. AGRAWAL, S., TEMSAMANI, J., and TANG, J.Y. (1991). Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice. Proc. Natl. Acad. Sci. USA 88, 7595-7599.
5. AHLERING, T.E., DUBEAU, L., and JONES, P.A. (1987). A new in vivo model to study invasion and metastasis of human bladder carcinoma. Cancer Res. 47, 6660-6665.
6. AKHTAR, S. (1995). Delivery Strategies for Antisense Oligonucleotide Therapeutics. (CRC Press, Boca Raton, FL).
7. BIGELOW, J.C., CHRIN, L.R., MATHEWS, L.A., and McCORMACK, J.J. (1990). High-performance liquid Chromatographic analysis of phosphorothioate analogues of oligodeoxynucleotides in biological fluids. J. Chromat. 533, 133-144.
8. ZENDEGUI, J.G., VASQUEZ, K.M., TINSLEY, J.H., KESSLER, D.J., and HOGAN, M.E. (1992). In vitro stability and kinetics of absorption and disposition of 3′ phosphopropyl amine oligonucleotides. Nucleic Acids Res. 20, 307-314.