Pharmacokinetics and metabolism of TR-14035, a novel antagonist of α4β1/α4β7 integrin mediated cell adhesion, in rat and dog

Xenobiotica

Volumn 35, Issue 4, 2005, Pages 373-389

  Tsuda Tsukimoto, Minoru ^a   Ogasawara, Y ^a   Kume, T ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

4 1 4 7 antagonist; Biliary excretion; Metabolism; Species difference; Sulfation; Urinary excretion

Indexed keywords

ALPHA4 BETA7 INTEGRIN ANTAGONIST; N (2,6 DICHLOROBENZOYL) 4 (2,6 DIMETHOXYPHENYL)PHENYLALANINE; PHENYLALANINE DERIVATIVE; TR 14035; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 4 ANTAGONIST;

ACTIVE TRANSPORT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE FLOW; CELL ADHESION; CONTROLLED STUDY; DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISPOSITION; DRUG METABOLISM; FIRST PASS EFFECT; GASTROINTESTINAL TRACT; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER METABOLISM; MALE; METABOLITE; NONHUMAN; RAT; SPECIES DIFFERENCE; URINARY EXCRETION;

ANIMALS; CELL ADHESION; DOGS; HUMANS; INTEGRIN ALPHA4BETA1; INTEGRINS; MALE; PHENYLALANINE; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY;

CANIS FAMILIARIS;

EID: 20944450917     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250500100235     Document Type: Article

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