Protective effects of Ginkgo biloba extract 761 against glutamate-induced neurotoxicity in cultured retinal neuron

Chinese Medical Journal

Volumn 118, Issue 11, 2005, Pages 948-952

  Wang, Yun Song ^a   Xu, Liang ^a   Ma, Ke ^a   Wang, Shuang ^a   Wang, Jin Jin ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Ginkgo biloba extract 761; Membrane potentials; Mitochondria; Neurons; Retina

Indexed keywords

GINKGO BILOBA EXTRACT; GLUTAMIC ACID; NEUROPROTECTIVE AGENT; RHODAMINE 123;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NERVE CELL CULTURE; NEUROPROTECTION; NEUROTOXICITY; NEUROTRANSMITTER RELEASE; NONHUMAN; RAT; RETINA NERVE CELL;

ANIMALS; CELLS, CULTURED; GINKGO BILOBA; GLUTAMIC ACID; IMMUNOHISTOCHEMISTRY; MEMBRANE POTENTIALS; MITOCHONDRIA; NEURONS; NEUROPROTECTIVE AGENTS; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; RETINA;

EID: 20944448827     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Ahlemeyer B, Krieglstein J. Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease. Pharmacopsychiatry 2003;36 (Suppl 1):S8-S14.
2. Kim MS, Lee JI, Lee WY, et al. Neuroprotective effect of Ginkgo biloba L. extract in a rat model of Parkinson' s disease. Phytother Res 2004;18:663-666.
3. Gertz HJ, Kiefer M. Review about ginkgo biloba special extract EGb761 (Ginkgo). Current Pharmaceutical Design 2004;10:261-264.
4. Yamauchi T, Kashii S, Yasuyoshi H, et al. Inhibition of glutamate-induced nitric oxide synthase activation by dopamine in cultured rat retinal neurons. Neuroscience Letters 2003;347:155-158.
5. 2+ load from rat adrenal chromaffin cells. Neuron 1996;16:219-228.
6. Scaduto RC Jr, Grotyohann LW. Measurement of mitochondrial membrane potential using fluoresent rhodamine derivatives. Biophs J 1999;76:469-477.
7. Brooks DE, Garcia GA, Dreyer EB, et al. Vitreous body glutamate concentration in dogs with glaucoma. Am J Vet Res 1997;58:864-867.
8. Dkhissi O, Chanut E, Wasowicz M, et al. Retinal TUNEL-positive cells and high glutamate levels in vitreous humor of mutant quail with a glaucoma-like disorder. Invest Ophthalmol Vis Sci 1999;40:990-995.
9. Vorwerk CK, Lipton SA, Zurakowski D, et al. Chronci low-dose glutamate is toxic to retinal ganglion cells: toxicity blocked by memantine. Invest Ophthalmol Vis Sci 1996;37:1618-1624.
10. Joo CK, Choi JS, Ko HW, et al. Necrosis and apoptosis after retinal ischemia: involvement of NMDA-mediated excitotoxicity and p53. Invest Ophthalmol Vis Sci 1999;40:713-720.
11. Adachi K, Kashii S, Masai H, et al. Mechanism of the pathogenesis of glutamate neurotoxicity in retinal ischemia. Graefes Arch Clin Exp Ophthalmol 1998; 236:766-774.
12. Lee JM, Zipfel GJ, Choi DW. The changing landscape of ischaemic brain injury mechanisms. Nature 1999; 399:A7-A14.
13. Stout AK, Raphael HM, Kanterewicz BI, et al. Glutamate-induced neuron death requires mitochondrial calcium uptake. Nat Neurosci 1998;1:366-373.
14. Ward MW, Rego AC, Frenguelli BG, et al. Mitochondrial membrane potential and glutamate excitotoxicity in cultured cerebellar granule cells. J Neurosci 2000;20:7208-7219.
15. Zimmermann M, Colciaghi F, Cattabeni F, et al. Ginkgo biloba extract: from molecular mechanisms to the treatment of Alzhelmer' s disease. Cell Mol Biol (Noisy-le-grand) 2002;48:613-623.
16. Chandrasekaran K, Mehrabian Z, Spinnewyn B, et al. Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb761) in global brain ischemia and in excitotoxicity-induced neuronal death. Pharmacopsychiatry 2003;36 (Suppl 1):S89S-S94.
17. Smith JV, Luo Y. Elevation of oxidative free radicals in Alzheimer's disease models can be attenuated by Ginkgo biloba extract EGb761. J Alzheimers Dis 2003; 5:287-300.
18. Droy-Lefaix MT. Effect of the antioxidant action of Ginkgo biloba extract (EGb761) on aging and oxidative stress. Age 1997;20:141-149.
19. Pierre S, Jamme I, Droy-Lefaix MT, et al. Ginkgo biloba extract (EGb761) protects NaK-ATPase activity during celebral ischemia in mice. NeuroReport 1999; 10:47-51.
20. Sastre J, Millan A, de la Asuncion JG, et al. A Ginkgo biloba extract (EGb761) prevents mitochondrial aging by protecting against oxidative stress. Free Radic Biol Med 1998;24:298-304.