Severe metformin intoxication with lactic acidosis in an adolescent

European Journal of Pediatrics

Volumn 164, Issue 6, 2005, Pages 362-365

  Lacher, Martin ^a   Hermanns Clausen, Maren ^a   Haeffner, Karsten ^a   Brandis, Matthias ^a   Pohl, Martin ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Haemodialysis; Intoxication; Lactic acidosis; Metformin

Indexed keywords

BICARBONATE; METFORMIN;

ADOLESCENT; ARTICLE; CASE REPORT; DISEASE COURSE; FEMALE; GLASGOW COMA SCALE; HEMODIALYSIS; HUMAN; INTOXICATION; KIDNEY FUNCTION; LABORATORY TEST; LACTIC ACIDOSIS; PRIORITY JOURNAL; SUICIDE;

ACIDOSIS, LACTIC; ADOLESCENT; FEMALE; HUMANS; KIDNEY FAILURE, ACUTE; METFORMIN; OVERDOSE; RENAL DIALYSIS; SUICIDE, ATTEMPTED;

EID: 20944442240     PISSN: 03406199     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00431-005-1634-y     Document Type: Article

References (21)

1. Apple FS (1989) Postmortem tricyclic antidepressant concentrations: assessing cause of death using parent drug to metabolite ratio. J Anal Toxicol 13: 197-198
2. Bailey CJ (1992) Biguanides and NIDDM. Diabetes Care 15: 755-772
3. Berner B, Hummel KM, Strutz F, Ritzel U, Ramadori G, Hagenlocher S, Kleine P, Muller GA (2002) Metformin-associated lactic acidosis with acute renal failure in type 2 diabetes mellitus. Med Klin (Munich) 97: 99-103
4. Chan NN, Brain HP, Feher MD (1999) Metformin-associated lactic acidosis: a rare or very rare clinical entity? Diabet Med 16: 273-281
5. Chang CT, Chen YC, Fang JT, Huang CC (2002) High anion gap metabolic acidosis in suicide: don't forget metformin intoxication - two patients' experiences. Ren Fail 24: 671-675
6. Dunn CJ, Peters DH (1995) Metformin. A review of its pharmacological properties and therapeutic use in non-insulin-dependent diabetes mellitus. Drugs 49: 721-749
7. Gjedde S, Christiansen A, Pedersen SB, Rungby J (2003) Survival following a metformin overdose of 63 g: a case report. Pharmacol Toxicol 93: 98-99
8. Heaney D, Majid A, Junor B (1997) Bicarbonate haemodialysis as a treatment of metformin overdose. Nephrol Dial Transplant 12: 1046-1047
9. Kirpichnikov D, McFarlane SI, Sowers JR (2002) Metformin: an update. Ann Intern Med 137: 25-33
10. Lacroix C, Hermelin A, Gerson M, Nouveau J, Guiberteau R (1988) Lactic acidosis caused by metformin. Value of intra-erythrocyte levels. Presse Med 17: 1158
11. Lalau JD, Race JM (1999) Lactic acidosis in metformin-treated patients. Prognostic value of arterial lactate levels and plasma metformin concentrations. Drug Safety 20: 377-384
12. Lalau JD, Lacroix C, Compagnon P, de Cagny B, Rigaud JP, Bleichner G, Chauveau P, Dulbecco P, Guerin C, Haegy JM (1995) Role of metformin accumulation in metformin-associated lactic acidosis. Diabetes Care 18: 779-784
13. McLelland J (1985) Recovery from metformin overdose. Diabet Med 2: 410-411
14. Moerer O, Barwing J, Neumann P (2004) Lactic acidosis and acute abdomen from biguanide intoxication. Anaesthesist 53: 153-156
15. Nisse P, Mathieu-Nolf M, Deveaux M, Forceville X, Combes A (2003) A fatal case of metformin poisoning. J Toxicol Clin Toxicol 41: 1035-1036
16. Pertek JP, Vidal S, Mariot J, Galy-Floch M, Azoulay E (2003) Metformin-associated lactic acidosis precipitated by acute renal failure. Ann Fr Anesth Reanim 22: 457-460
17. Scheen AJ (1996) Clinical pharmacokinetics of metformin. Clin Pharmacokinet 30: 359-371
18. Spiller HA, Weber JA, Winter ML, Klein-Schwartz W, Hofman M, Gorman SE, Stork CM, Krenzelok EP (2000) Multi-center case series of pediatric metformin ingestion. Ann Pharmacother 34: 1385-1388
19. Stades AM, Heikens JT, Erkelens DW, Holleman F, Hoekstra JB (2004) Metformin and lactic acidosis: cause or coincidence? A review of case reports. J Intern Med 255: 179-187
20. Teale KF, Devine A, Stewart H, Harper NJ (1998) The management of metformin overdose. Anaesthesia 53: 698-701
21. Wilcock C, Bailey CJ (1994) Accumulation of metformin by tissues of the normal and diabetic mouse. Xenobiotica 24: 49-57