The GADD45, ZBRK1 and BRCA1 pathway: Quantitative analysis of mRNA expression in colon carcinomas

Journal of Pathology

Volumn 206, Issue 1, 2005, Pages 92-99

  Garcia, Vanesa ^a   García, José M ^a   Peña, Cristina ^a   Silva, Javier ^a   Domínguez, Gemma ^a   Rodríguez, Rufo ^b   Maximiano, Constanza ^a   Espinosa, Ruth ^a   España, Pilar ^a   Bonilla, Félix ^a  

^a HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^b HOSPITAL VIRGEN DE LA SALUD   (Spain)

Author keywords

BRCA1; Colon carcinomas; GADD45; Gene expression; Real time RT PCR; ZBRK1

Indexed keywords

MESSENGER RNA;

ARTICLE; COLON CARCINOMA; CONTROLLED STUDY; DNA DAMAGE; GADD45 GENE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; INTRON; MESSENGER RNA SYNTHESIS; ONCOGENE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE; ZBRK1 GENE;

ADENOCARCINOMA; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; COLONIC NEOPLASMS; DNA METHYLATION; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, BRCA1; GENETIC MARKERS; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STATISTICS, NONPARAMETRIC;

EID: 20944439681     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1751     Document Type: Article

References (25)

1. 2/M cell cycle checkpoint. Proc Natl Acad Sci USA 1999; 96: 3706-3711.
2. Hollander MC, Sheikh MS, Bulavin DV, et al. Genomic instability in Gadd45a-deficient mice. Nature Genet 1999; 23: 176-184.
3. Harkin DP, Bean JM, Miklos D, et al. Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1. Cell 1999; 97: 575-586.
4. Kastan MB, Zhan Q, el-Deiry WS, et al. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia telangiectasia. Cell 1992; 71: 587-597.
5. Takahashi S, Saito S, Ohtani N, Sakai T. Involvement of the Oct-1 regulatory element of the Gadd45 promoter in the p53-independent response to ultraviolet irradiation. Cancer Res 2001; 61: 1187-1195.
6. Hirose T, Sowa Y, Takahashi S, et al. p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y. Oncogene 2003; 22: 7762-7773.
7. Ford D, Easton DF, Bishop DT, et al. Risks of cancer in BRCA-mutation carriers. Lancet 1994; 343: 692-695.
8. García-Patiño E, Gomendio B, Lleonart M, et al. Loss of heterozygosity in the region including the BRCA1 gene on 17q in colon cancer. Cancer Genet Cytogen 1998; 104: 19-23.
9. García JM, Rodríguez R, Domínguez G, et al. Prognostic significance of the allelic loss of the BRCA1 gene in colorectal cancer. Gut 2003; 52: 1756-1763.
10. Scully R, Livingston DM. In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature 2000; 408: 429-432.
11. Deng CX, Brodie SG. Roles of BRCA1 and its interacting proteins. BioEssays 2000; 22: 728-737.
12. Somasundaram K. Breast cancer gene 1 (BRCA1): role in cell cycle regulation and DNA repair - perhaps through transcription. J Cell Biochem 2003; 88: 1084-1091.
13. Jin S, Zhao H, Fan F, et al. BRCA1 activation of the GADD45 promoter. Oncogene 2000; 19: 4050-4057.
14. Fan W, Jin S, Tong T, et al. BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs. J Biol Chem 2002; 277: 8061-8067.
15. Zheng L, Pan H, Li S, et al. Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. Mol Cell 2000; 6: 757-768.
16. Tan W, Kim S, Boyer TG. Tetrameric oligomerization mediates transcriptional repression by the BRCA1-dependent KRAB-zinc finger protein ZBRK1. J Biol Chem 2004; 279: 55 153-55 160.
17. Yun J, Lee WH. Degradation of transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45a upon DNA damage. Mol Cell Biol 2003; 23: 7305-7314.
18. García V, Domínguez G, García JM, et al. Altered expression of the ZBRK1 gene in human breast carcinomas. J Pathol 2004; 202: 224-232.
19. Silva J, Silva JM, Domínguez G, et al. Concomitant expression of p16INK4a and p14ARF in primary breast cancer and analysis of inactivation mechanisms. J Pathol 2003; 199: 289-297.
20. Bianco T, Hussey D, Dobrovic A. Methylation-sensitive, single-strand conformational analysis (MS-SSCA): a rapid method to screen for and analyze methylation. Hum Mutat 1999; 14: 289-293.
21. Oto M, Miyake S, Yuasa Y. Optimization of nonradioisotopic single strand conformation polymorphism analysis with a conventional minislab gel electrophoresis apparatus. Ann Biochem 1993; 213: 19-22.
22. Rutter JL, Smith AM, Davila MR, et al. Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals. Hum Mutat 2003; 22: 121-128.
23. Sigurdson AJ, Hauptmann M, Chatterjee N, et al. Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes. BMC Cancer 2004; 4: 9.
24. Collins T, Stone JR, Williams AJ. All in the family: the BTB/POZ, KRAB, and SCAN domains. Mol Cell Biol 2001; 21: 3609-3615.
25. Li S, Ting NS, Zheng L, et al. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature 2000; 406: 210-215.