Antagonism of epidermal growth factor receptor tyrosine kinase ameliorates the psoriatic phenotype in organ-cultured skin

Skin Pharmacology and Physiology

Volumn 18, Issue 3, 2005, Pages 123-131

  Varani, J ^a   Lateef, H ^a   Fay, K ^a   Elder, J T ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Epidermal growth factor; Fibroblasts; Keratinocytes; Matrix metalloproteinases; Psoriasis; Receptor tyrosine kinase (EGF RTK) antagonist; Skin organ culture; Type I procollagen

Indexed keywords

COLLAGEN TYPE 1; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; INTERSTITIAL COLLAGENASE; PD 169540; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DERMIS; DRUG EFFECT; ENZYME INHIBITION; FIBROBLAST; GROWTH INHIBITION; HISTOLOGY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; ORGAN CULTURE; PHENOTYPE; PRIORITY JOURNAL; PSORIASIS; SKIN; SKIN FUNCTION;

BLOTTING, WESTERN; CELL PROLIFERATION; CELLS, CULTURED; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; FIBROBLASTS; HUMANS; KERATINOCYTES; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 2; ORGAN CULTURE TECHNIQUES; PHENOTYPE; PROCOLLAGEN; PSORIASIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SKIN;

EID: 20944436301     PISSN: 16605527     EISSN: None     Source Type: Journal    
DOI: 10.1159/000084909     Document Type: Article

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