NR4A orphan nuclear receptor family in peripheral blood eosinophils from patients with atopic dermatitis and apoptotic eosinophils in vitro

International Archives of Allergy and Immunology

Volumn 137, Issue SUPPL., 2005, Pages 35-44

  Kagaya, Shinji ^a   Hashida, Ryoichi ^a,c   Ohkura, Naganari ^b   Tsukada, Toshihiko ^b   Sugita, Yuji ^a   Terakawa, Maki ^d   Tsujimoto, Gozoh ^d   Katsunuma, Toshio ^d   Akasawa, Akira ^d   Matsumoto, Kenji ^d   Saito, Hirohisa ^d  

^a Genox Research Inc   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c EISAI CO LTD   (Japan)

^d NONE

Author keywords

Apoptosis; Atopic dermatitis; CD30; Eosinophil; Gene expression; GeneChip; NOR1; NR4A nuclear receptor family; Nur77; Nurr1; Real time RT PCR

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; CD30 ANTIGEN; CELL NUCLEUS RECEPTOR; FAS ANTIBODY; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NUCLEAR RECEPTOR NR4A; NUCLEAR RECEPTOR RELATED FACTOR 1; RNA; UNCLASSIFIED DRUG; 1,3 BUTADIENE DERIVATIVE; CELL RECEPTOR; DNA BINDING PROTEIN; ENZYME INHIBITOR; FAS ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; NITRILE; NUCLEAR RECEPTOR NUR77; STEROID RECEPTOR; TRANSCRIPTION FACTOR;

ADULT; APOPTOSIS; ATOPIC DERMATITIS; BLOOD; CELL FRACTIONATION; CELL SPECIFICITY; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; EOSINOPHIL; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; LEUKOCYTE; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; UPREGULATION; ADOLESCENT; ARTICLE; CHEMISTRY; CHILD; DNA MICROARRAY; DRUG ANTAGONISM; GENETICS; IMMUNOLOGY; INFANT; METABOLISM; MIDDLE AGED; PATHOLOGY; PRESCHOOL CHILD; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADOLESCENT; ADULT; ANTIGENS, CD30; ANTIGENS, CD95; APOPTOSIS; BUTADIENES; CHILD; CHILD, PRESCHOOL; DERMATITIS, ATOPIC; DNA-BINDING PROTEINS; ENZYME INHIBITORS; EOSINOPHILS; FEMALE; GENE EXPRESSION; HUMANS; INFANT; MALE; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASES; NITRILES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TRANSCRIPTION FACTORS;

EID: 20844459103     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000085430     Document Type: Conference Paper

References (48)

1. Gleich GJ: Mechanisms of eosinophil-associated inflammation. J Allergy Clin Immunol 2000;105:651-663.
2. Holt PG, Macaubas C, Stumbles PA, Sly PD: The role of allergy in the development of asthma. Nature 1999;402(suppl):B12-B17.
3. Wills-Karp M, Karp CL: Eosinophils in asthma: Remodeling a tangled tale. Science 2004;305:1726-1728.
4. Kristin M, Leiferman MD: Eosinophils in atopic dermatitis. J Allergy Clin Immunol 1994;94:1310-1317.
5. Kapp A: The role of eosinophils in the pathogenesis of atopic dermatitis - eosinophil granule proteins as markers of disease activity. Allergy 1993;48:1-5.
6. Liang P, Pardee AB: Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 1992;257:967-971.
7. Ito T, Kito K, Adati N, Mitsui Y, Hagiwara H, Sakaki Y: Fluorescent differential display: Arbitrary primed RT-PCR fingerprinting on an automatic DNA sequencer. FEBS Lett 1994;351:231-236.
8. Schmidt-Weber CB, Wohlfahrt JG, Blaser K: DNA arrays in allergy and immunology. Int Arch Allergy Immunol 2001;126:1-10.
9. Granucci F, Castagnoli PR, Rogge L, Sinigaglia F: Gene expression profiling in immune cells using microarray. Int Arch Allergy Immunol 2001;126:257-266.
10. Lie YS, Petropoulos CJ: Advances in quantitative PCR technology: 5′-Nuclease assays. Curr Opin Biotechnol 1998;9:43-48.
11. Kafert S, Krauter J, Ganser A, Eder M: Differential quantitation of alternatively spliced messenger RNAs using isoform-specific real-time RT-PCR. Anal Biochem 1999;269:210-213.
12. Hashida R, Ogawa K, Miyagawa M, Sugita Y, Takahashi E, Nagasu T, Katsunuma T, Akasawa A, Tsujimoto G, Matsumoto K, Saito H: Analysis of gene expression in peripheral blood eosinophils from patients with atopic dermatitis by differential display. Int Arch Allergy Immunol 2003;131(suppl 1):26-33.
13. Murphy EP, Dobson AD, Keller C, Conneely OM: Differential regulation of transcription by the NURR1/NUR77 subfamily of nuclear transcription factors. Gene Expr 1996;5:169-179.
14. Murphy EP, Conneely OM: Neuroendocrine regulation of the hypothalamic pituitary adrenal axis by the nurr1/nur77 subfamily of nuclear receptors. Mol Endocrinol 1997;11:39-47.
15. Da Costa AP, Kampa RJ, Windle RJ, Ingram CD, Lightman SL: Region-specific immediate-early gene expression following the administration of corticotropin-releasing hormone in virgin and lactating rats. Brain Res 1997;770:151-162.
16. Sakurada K, Ohshima-Sakurada M, Palmer TD, Gage FH: Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain. Development 1999;126:4017-4026.
17. Satoh J, Kuroda Y: The constitutive and inducible expression of Nurr1, a key regulator of dopaminergic neuronal differentiation, in human neural and non-neural cell lines. Neuropathology 2002;22:219-232.
18. Scearce LM, Laz TM, Hazel TG, Lau LF, Taub R: RNR-1, a nuclear receptor in the NGFI-B/Nur77 family that is rapidly induced in regenerating liver. J Biol Chem 1993;268:8855-8861.
19. He YW: Orphan nuclear receptors in T lymphocyte development. J Leukoc Biol 2002;72:440-446.
20. Steff AM, Trop S, Maira M, Drouin J, Hugo P: Opposite ability of pre-TCR and alpha beta TCR to induce apoptosis. J Immunol 2001;166:5044-5050.
21. Winoto A, Littman DR: Nuclear hormone receptors in T lymphocytes. Cell 2002;109:S55-S66.
22. Cheng LE, Chan FK, Cado D, Winoto A: Functional redundancy of the Nur77 and Nor1 orphan steroid receptors in T-cell apoptosis. EMBO J 1997;16:1865-1875.
23. Matsumoto K, Terakawa M, Miura K, Fukuda S, Nakajima T, Saito H: Extremely rapid and intense induction of apoptosis in human eosinophils by anti-CD30 antibody treatment in vitro. J Immunol 2004;172:2186-2193.
24. Hanifin JM: Basic and clinical aspects of atopic dermatitis. Ann Allergy 1984;52:386-395.
25. Nomura I, Tanaka K, Tomita H, Katsunuma T, Ohya Y, Ikeda N, Takeda T, Saito H, Akasawa A: Evaluation of the staphylococcal exotoxins and their specific IgE in childhood atopic dermatitis. J Allergy Clin Immunol 1999;104:441-446.
26. Ogawa K, Hashida R, Miyagawa M, Kagaya S, Sugita Y, Matsumoto K, Katsunuma T, Akasawa A, Tsujimoto G, Saito H: Analysis of gene expression in peripheral blood eosinophils from patients with atopic dermatitis and in vitro cytokine-stimulated blood eosinophils. Clin Exp Immunol 2003;131:436-445.
27. Vermes I, Haanen C, Steffen-Nakken H, Reutelingsperger C: A novel assay for apoptosis: Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled annexin V. J Immunol Methods 1995;184:39-51.
28. Baumann MA, Paul CC: The AML14 and AML14.3D10 cell lines: A long-overdue model for the study of eosinophils and more. Stem Cells 1998;16:16-24.
29. Hashida R, Ogawa K, Miyagawa M, Sugita Y, Matsumoto K, Akasawa A, Saito H: Gene expression accompanied by differentiation of cord blood-derived CD34+ cells to eosinophils. Int Arch Allergy Immunol 2001;125(suppl 1):2-6.
30. Robinson-Rechavi M, Carpentier AS, Duffraisse M, Landet V: How many nuclear hormone receptors are there in the human genome? Trends Genet 2001;17:554-556.
31. Matsumoto Y, Oshida T, Obayashi I, Imai Y, Matsui K, Yoshida NL, Nagata N, Ogawa K, Obayashi M, Kashiwabara T, Gunji S, Nagasu T, Sugita Y, Tanaka T, Tsujimoto G, Katsunuma T, Akasawa A, Saito H: Identification of highly expressed genes in peripheral blood T cells from patients with atopic dermatitis. Int Arch Allergy Immunol 2002;129:327-340.
32. Heishi M, Kagaya S, Katsunuma T, Nakajima T, Yuki K, Akasawa A, Maeda M, Gunji S, Sugita Y, Tsujimoto G, Saito H: High-density oligonucleotide array analysis of mRNA transcripts in peripheral blood cells of severe atopic dermatitis patients. Int Arch Allergy Immunol 2002;129:57-66.
33. Lopez AF, Williamson DJ, Gamble JR, Begley CG, Harlan JM, Klebanoff SJ, Waltersdorph A, Wong G, Clark SC, Vadas MA: Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival. J Clin Invest 1986;78:1220-1228.
34. Rothenberg ME, Owen WF Jr, Silberstein DS, Woods J, Soberman RJ, Austen KF, Stevens RL: Human eosinophils have prolonged survival, enhanced functional properties, and become hypodense when exposed to human interleukin 3. J Clin Invest 1988;81:1986-1992.
35. Tai PC, Sun L, Spry CJ: Effects of IL-5, granulocyte/macrophage colony-stimulating factor (GM-CSF) and IL-3 on the survival of human blood eosinophils in vitro. Clin Exp Immunol 1991;85:312-316.
36. Wedi B, Raap U, Lewrick H, Kapp A: IL-4-induced apoptosis in peripheral blood eosinophils. J Allergy Clin Immunol 1998;102:1013-1020.
37. Schleimer RP, Bochner BS: The effects of glucocorticoids on human eosinophils. J Allergy Clin Immunol 1994;94:1202-1213.
38. Matsukura M, Yamada H, Yudate T, Tezuka T, Chihara J: Corticosteroid-induced apoptosis of eosinophils in atopic dermatitis patients. J Clin Lab Immunol 1996;48:109-122.
39. Zang X, Moilanen E, Kankaanranta H: Enhancement of human eosinophil apoptosis by fluticasone propionate, budesonide, and beclomethasone. Eur J Pharmacol 2000;20:325-332.
40. Bengtsson A, Holm L, Back O, Fransson J, Scheynius A: Elevated serum levels of soluble CD30 in patients with atopic dermatitis (AD). Clin Exp Immunol 1997;109:533-537.
41. Caproni M, Salvatore E, Cardinali C, Brazzini B, Fabbri P: Soluble CD30 and cyclosporine in severe atopic dermatitis. Int Arch Allergy Immunol 2000;121:324-328.
42. Hargreaves PG, Al-Shamkhani A: Soluble CD30 binds to CD153 with high affinity and blocks transmembrane signaling by CD30. Eur J Immunol 2002;32:163-173.
43. Aizawa S, Nakano H, Ishida T, Horie R, Nagai M, Ito K, Yagita H, Okumura K, Inoue J, Watanabe T: Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkB activation. J Biol Chem 1997;272:2042-2045.
44. Duckett CS, Thompson CB: CD30-dependent degradation of TRAF2: Implications for negative regulation of TRAF signaling and the control of cell survival. Gene Dev 1997;11:2810-2821.
45. Duckett CS, Gedrich RW, Gilfillan MC, Thompson CB: Induction of nuclear factor kB by the CD30 receptor in mediated by TRAF1 and TRAF2. Mol Cell Biol 1997;17:1535-1542.
46. Horie R, Aizawa S, Nagai M, Ito K, Higashihara M, Ishida T, Inoue J, Watanabe T: A novel domain in the CD30 cytoplasmic tail mediates NFkB activation. Int Immunol 1998;10:203-210.
47. Lee SY, Park CG, Choi Y: T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors. J Exp Med 1996; 183:669-674.
48. Maruyama K, Tsukada T, Ohkura N, Bandoh S, Hosono T, Yamaguchi K: The NGFI-B subfamily of the nuclear receptor superfamily (review). Int J Oncol 1998;12:1237-1243.