Connective tissue growth factor promotes the proliferation of myofibroblast through Erk-1/2 signaling pathway

National Medical Journal of China

Volumn 85, Issue 19, 2005, Pages 1322-1326

  Huang, Hai Chang ^a   Yang, Min ^a   Li, Jing Zi ^a   Wang, Hai Yan ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

Author keywords

Connective tissue; Fibroblasts; Growth substances; Transforming growth factor beta

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ALPHA SMOOTH MUSCLE ACTIN; BROXURIDINE; CONNECTIVE TISSUE GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; KIDNEY CELL; MYOFIBROBLAST; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; CELL DIVISION; CELLS, CULTURED; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 3; RATS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 20744431782     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Badid C, Vincent M, Fouque D, et al. Myofibroblast: a prognostic marker and target cell in progressive renal disease. Ren Fail, 2001, 23:543-549.
2. Tomasek JJ, Gabbiani G, Hinz B, et al. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol,2002, 3:349-363.
3. Gabbiani G. The myofibroblast in wound healing and fibrocontractive diseases. J Pathol, 2003, 200:500-503.
4. Garrett Q, Khaw PT, Blalock TD, et al. Involvement of CTGF in TGF-beta1-stimulation of myofibroblast differentiation and collagen matrix contraction in the presence of mechanical stress. Invest Ophthalmol Vis Sci, 2004, 45:1109-1116.
5. Yang J, Dai C, Liu Y. Hepatocyte growth factor suppresses renal interstitial myofibroblast activation and intercepts Smad signal transduction. Am J Pathol, 2003, 163:621-632.
6. Frazier K, Williams S, Kothapalli D, et al. Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor. J Invest Dermatol, 1996, 107:404-411.
7. Duncan MR, Frazier KS, Abramson S, et al. Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP. FASEB J, 1999, 13: 1774-1186.
8. Yang M, Huang HC, Li JZ, et al. Connective tissue growth factor synergistically with transforming growth factor beta1 to promote renal fibrosis. Natl Med J China, 2004, 84:569-573.
9. Paradis V, Dargere D, Bonvoust F, et al. Effects and regulation of connective tissue growth factor on hepatic stellate cells. Lab Invest, 2002, 82:767-774.
10. Yang M, Huang HC, Li JZ, et al. Basic Med Sci Clin, 2005,25: 25-29.
11. Folger PA, Zekaria D, Grotendorst G, et al. Transforming growth factor-beta-stimulated connective tissue growth factor expression during corneal myofibroblast differentiation. Invest Ophthalmol Vis Sci, 2001, 42:2534-2541.
12. Hayashida T, Poncelet AC, Hubchak SC, et al. TGF-beta1 activates MAP kinase in human mesangial cells: a possible role in collagen expression. Kidney Int, 1999, 56:1710-1720.
13. Shimo T, Nakanishi T, Kimura Y, et al. Inhibition of endogenous expression of connective tissue growth factor by its antisense oligonucleotide and antisense RNA suppresses proliferation and migration of vascular endothelial cells. J Biochem, 1998, 124:130-140.
14. Yosimichi G, Nakanishi T, Nishida T, et al. CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen-activated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase (ERK). Eur J Biochem, 2001, 268:6058-6065.
15. Hewitson TD, Martic M, Kelynack KJ, et al. Pentoxifylline reduces in vitro renal myofibroblast proliferation and collagen secretion. Am J Nephrol,2000, 20:82-88.