Attenuation of graft injury in porcine liver transplantation from non-heart beating donor by FR167653

Hepato-Gastroenterology

Volumn 52, Issue 63, 2005, Pages 885-892

  Ono, Hiroaki ^a   Totsuka, Eishi ^a   Hakamada, Kenichi ^a   Ishizawa, Yoshiya ^a   Nishimura, Akimasa ^a   Umehara, Minoru ^a   Nara, Masaki ^a   Takiguchi, Makoto ^a   Takahashi, Katsuro ^a   Murata, Akihiko ^a   Toyoki, Yoshikazu ^a   Narumi, Shunji ^a   Sasaki, Mutsuo ^a  

^a HIROSAKI UNIVERSITY   (Japan)

Author keywords

Cytokine; FR167653; Liver transplantation; Non heart beating donor

Indexed keywords

1 [7 (4 FLUOROPHENYL) 1,2,3,4 TETRAHYDRO 8 (4 PYRIDYL)PYRAZOLO[5,1 C][1,2,4]TRIAZIN 2 YL] 2 PHENYLETHANEDIONE; ADENOSINE TRIPHOSPHATE; ANTIINFLAMMATORY AGENT; ASPARTATE AMINOTRANSFERASE; BILE ACID; INTERLEUKIN 1BETA; LACTIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; AORTA CLAMPING; ARTICLE; BIOSYNTHESIS; CAUSE OF DEATH; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; DRUG MECHANISM; HISTOPATHOLOGY; LEUKOCYTE ACTIVATION; LIVER BIOPSY; LIVER BLOOD FLOW; LIVER CIRCULATION; LIVER FAILURE; LIVER FUNCTION TEST; LIVER GRAFT; LIVER INJURY; LIVER ISCHEMIA; LIVER PERFUSION; LIVER PROTECTION; LIVER TRANSPLANTATION; MICROCIRCULATION; NEUTROPHIL; NONHUMAN; ORGAN DONOR; PRIORITY JOURNAL; RECIPIENT; REPERFUSION INJURY; SURVIVAL RATE; SWINE;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYTOKINES; GRAFT SURVIVAL; IMMUNOSUPPRESSIVE AGENTS; LIVER; LIVER FUNCTION TESTS; LIVER TRANSPLANTATION; MICROCIRCULATION; NEUTROPHIL ACTIVATION; ORGAN PRESERVATION; PREMEDICATION; PYRAZOLES; PYRIDINES; REPERFUSION INJURY; SWINE;

EID: 20644471187     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. D'Alessandro AM, Hoffmann RM, Knechtle SJ, Eckhoff DE, Love RB, Kalayoglu M, Sollinger HW, Belzer FO: Successful extrarenal transplantation from non-heart-beating donors. Transplantation 1995; 59:977-982.
2. Casavilla A, Ramirez C, Shapiro R, Nghiem D, Miracle K, Bronsther O, Randhawa P, Broznick B, Fung JJ, Starzl T: Experience with liver and kidney allografts from non-heart-beating donors. Transplantation 1995; 59:197-203.
3. Totsuka E, Fung JJ, Hakamada K, Narumi S, Sasaki M: Experience of orthotopic liver transplantation from non-heart-beating donor in University of Pittsburgh Medical Center. Nippon Geka Gakkai Zasshi 1999; 100:818-821.
4. Takada Y, Taniguchi H, Fukunaga K, Yuzawa K, Otsuka M, Todoroki T, Iijima T, Fukao K: Prolonged hepatic warm ischemia in non-heart-beating donors: protective effects of FK506 and a platelet activating factor antagonist in porcine liver transplantation. Surgery 1998; 123:692-698.
5. Toledo-Pereyra LH, Suzuki S: Cellular and biomolecular mechanisms of liver ischemia and reperfusion injury. Transplant Proc 1994; 26:325-327.
6. Granger DN: Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury. Am J Physiol 1988; 255:H1269-1275.
7. Totsuka E, Sasaki M, Takahashi K, Toyoki Y, Seino K, Chiba S, Narumi S, Hakamada K, Morita T, Konn M: The effect of intraportal prostaglandin E1 administration on hepatic warm ischemia and reperfusion injury in dog. Surg Today 1995; 25:421-428.
8. Totsuka E, Todo S, Zhu Y, Ishizaki N, Kawashima Y, Jin MB, Urakami A, Shimamura T, Starzl TE: Attenuation of ischemic liver injury by prostaglandin E1 analogue, misoprostol, and prostaglandin 12 analogue, OP-41483. J Am Coll Surg 1998; 187:276-286.
9. Hakamada K, Sasaki M, Takahashi K, Umehara Y, Konn M: Sinusoidal flow block after warm ischemia in rats with diet-induced fatty liver. J Surg Res 1997; 70:12-20.
10. Shimamura T, Zhu Y, Zhang S, Jin MB, Ishizaki N, Urakami A, Totsuka E, Kishida A, Lee R, Subbotin V, Furukawa H, Starzl TE, Todo S: Protective role of nitric oxide in ischemia and reperfusion injury of the liver. J Am Coll Surg 1999; 188:43-52.
11. Kumamoto Y, Suematsu M, Shimazu M, Kato Y, Sano T, Makino N, Hirano KI, Naito M, Wakabayashi G, Ishimura Y, Kitajima M: Kupffer cell-independent acute hepatocellular oxidative stress and decreased bile formation in post-cold-ischemic rat liver. Hepatology 1999; 30:1454-1463.
12. Suzuki S, Toledo-Pereyra LH, Rodriguez F, Lopez F: Role of Kupffer cells in neutrophil activation and infiltration following total hepatic ischemia and reperfusion. Circ Shock 1994; 42:204-209.
13. Wood JG, Yan ZY, Zhang Q, Cheung LY: Ischemia-reperfusion increases gastric motility and endothelin-1-induced vasoconstriction. Am J Physiol 1995; 269:G524-531.
14. Tanaka M, Brooks SE, Richard VJ, FitzHarris GP, Stoler RC, Jennings RB, Arfors KE, Reimer KA: Effect of anti-CD18 antibody on myocardial neutrophil accumulation and infarct size after ischemia and reperfusion in dogs. Circulation 1993; 87:526-535.
15. Takiguchi M, Totsuka E, Umehara M, Ono H, Nara M, Nozaki T, Wajima N, Takahashi K, Narumi S, Hakamada K, Sugai M, Sasaki M: Attenuation of microcirculatory disturbance after liver ischemia by newly synthesized inflammatory cytokine suppressor, FR167653. Hepatogastroenterology 2003; 50:789-793.
16. Takiguchi M, Tostuka E, Umehara M, Chang TH, Nara M, Nozaki T, Wajima N, Takahashi K, Seino K, Narumi S, Sugsi M, Hakamada K, Sasaki M: Attenuation of hepatic warm ischemia-reperfusion injury associated with neutrophil infiltration by cytokine suppressive anti-inflammatory agent, FR167653. Hirosaki Med J 2001; 53:26-32.
17. Starzl TE, Hakala TR, Shaw BW Jr, Hardesty RL, Rosenthal TJ, Griffith BP, Iwatsuki S, Bahnson HT: A flexible procedure for multiple cadaveric organ procurement. Surg Gynecol Obstet 1984; 158:223-230.
18. Imagawa DK, Olthoff KM, Yersiz H, Shackleton CR, Colquhoun SD, Shaked A, Busuttil RW: Rapid en bloc technique for pancreas-liver procurement. Transplantation 1996; 61:1605-1609.
19. Totsuka E, Nara M, Takiguchi M, Nozaki T, Yoshida A, Wajima N, Takahashi K, Seino K, Narumi S, Hakamada K, Sasaki M: Influence of prolonged harvesting time during organ procurement on early graft outcome in human liver transplantation. Hirosaki Med J 2000; 51:80-85.
20. Starzl TE, Iwatsuki S, Esquivel CO, Todo S, Kam I, Lynch S, Gordon RD, Shaw BW Jr: Refinements in the surgical technique of liver transplantation. Semin Liver Dis 1985; 5:349-356.
21. Mashige F, Imai K, Osuga T: A simple and sensitive assay of total serum bile acids. Clin Chim Acta 1976; 70:79-86.
22. Williamson DH, Lund P, Krebs HA: The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of the rat liver. Biochem J 1967; 103:514-527.
23. Ozawa K: Hepatic function and liver resection. J Gastroenterol Hepatol 1990; 5:296-309.
24. Atkinson DE: The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. Biochemistry 1968; 7:4030-4034.
25. Moloney WC, McPherson K, Fliegelman L: Esterase activity in leukocytes demonstrated by the use of naphtol AS-D chloroacetate substrate. J Histochem Cytochem 1960; 8:200-207.
26. Yamamoto N, Sakai F, Yamazaki H, Nakahara K, Okuhara M: Effect of FR167653, a cytokine suppressive agent, on endotoxin-induced disseminated intravascular coagulation. Eur J Pharmacol 1996; 314:137-142.
27. Hamamoto N, Sakai F, Yamazaki H, Natsuki S, Nakahara K, Okuhara M: FR167653, a dual inhibitor of interleukin-1 and tumor necrosis factor-alpha, ameliorates endotoxin-induced shock. Eur J Pharmacol 1997; 327:169-175.
28. Kamoshita N, Takeyoshi I, Ohwada S, Iino Y, Morishita Y: The effects of FR167653 on pulmonary ischemia-reperfusion injury in dogs. J Heart Lung Transplant 1997; 16:1062-1072.
29. Lee JC, Laydon JT, McDonnell PC, Gallagher TF, Kumar S, Green D, McNulty D, Blumenthal MJ, Heys JR, Landvatter SW: A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 1994; 372:739-746.
30. Takeyoshi I, Otani Y, Koibuchi Y, Yokoe T, Iino Y, Matsumoto K, Muramoto M, Satoh S, Morishita Y: Effects of FR167653 on pulmonary ischemia-reperfusion injury. Administration timing. Transplant Proc 1999; 31:1935-1936.
31. Kiuchi K, Ozawa K, Yamamoto Y, Takayasu T, Maki A, Shimahara Y, Mori K, Kobayashi N, Yamaoka Y, Kumada K: Changes in arterial ketone body ratio in the phase immediately after hepatectomy. Arch Surg 1990; 125:655-659.
32. Benvenisti J, Chignard M: A role of PAF-acether in platelet dependent vascular diseases? Circulation 1985; 72:713-717.
33. Hamburger SA, McEver RP: GMP-140 mediates adhesion of stimulated platelets to neutrophils. Blood 1990; 75:550-554.
34. Read MA, Neish AS, Luscinskas FW, Palombella VJ, Maniatis T, Collins T: The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression. Immunity 1995; 2:493-596.
35. Lentsch AB, Kato A, Yoshidome H, McMasters KM, Edwards MJ: Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia/reperfusion injury. Hepatology 2000; 32:169-173.
36. Visser JJ, Bom-van Noorloos AA, Meijer S, Hoitsma HF: Serum total bile acids monitoring after experimental orthotopic liver transplantation. J Surg Res 1984; 36:147-153.
37. Sato M, Ohkohchi N, Tsukamoto S, Koyamada N, Asakura T, Enomoto Y, Usuda M, Miyagi S, Okada A, Satomi S: Successful liver transplantation from agonal non-heart-beating donors in pigs. Transpl Int 2003; 16:100-107.
38. Kawashima Y, Jin MB, Urakami A, Zhang S, Zhu Y, Ishizaki N, Shimamura T, Totsuka E, Lee RG, Subbotin VM, Starzl TE, Todo S: Amelioration of liver damage induced by ischemia and reperfusion with FR167653; A newly synthesized cytokine suppressive antiinflammatory drug. Transplant Proc 1998; 30:49-52.
39. Kobayashi J, Takeyoshi I, Ohwada S, Iwanami K, Matsumoto K, Muramoto M, Morishita Y: The effects of FR167653 in extended liver resection with ischemia in dogs. Hepatology 1998; 28:459-465.