Heparin regulates transcription of endothelin-1 gene in endothelial cells

Journal of Vascular Research

Volumn 42, Issue 3, 2005, Pages 183-189

  Kuwahara Watanabe, Kazue ^a   Hidai, Chiaki ^b   Ikeda, Hiromi ^a   Aoka, Yoshikazu ^a   Ichikawa, Ken Ichiro ^a   Iguchi, Nobuo ^b   Okada Ohno, Masako ^a   Yokota, Jinko ^a   Kasanuki, Hiroshi ^b   Kawana, Masatoshi ^a,c  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b NIHON UNIVERSITY   (Japan)

^c NONE   (Japan)

Author keywords

AP 1; Endothelial cell; Endothelin 1; ERK; GATA; Heparin; Transcription

Indexed keywords

CIS ACTING ELEMENT; ENDOTHELIN 1; HEPARIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; OLIGONUCLEOTIDE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR GATA; UNCLASSIFIED DRUG; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANTICOAGULANT AGENT; FLAVONOID;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BINDING AFFINITY; CELL CULTURE; CELL LINE; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INHIBITION KINETICS; NONHUMAN; PHARMACOGENETICS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN MODIFICATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; WESTERN BLOTTING; ANIMAL; AORTA; CATTLE; CYTOLOGY; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALS; ANTICOAGULANTS; AORTA; CATTLE; CELLS, CULTURED; DOWN-REGULATION; ENDOTHELIAL CELLS; ENDOTHELIN-1; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; HEPARIN; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 20644470963     PISSN: 10181172     EISSN: None     Source Type: Journal    
DOI: 10.1159/000084656     Document Type: Article

References (37)

1. Kedzierski RM, Yanagisawa M: Endothelin system: The double-edged sword in health and disease. Annu Rev Pharmacol Toxicol 2001;41:851-876.
2. Bousette N, Giaid A: Endothelin-1 in atherosclerosis and other vasculopathies. Can J Physiol Pharmacol 2003;81:578-587.
3. Iglarz M, Schiffrin EL: Role of endothelin-1 in hypertension. Curr Hypertens Rep 2003;5:144-148.
4. Corder R, Barker S: The expression of endothelin-1 and endothelin-converting enzyme-1 (ECE-1) are independently regulated in bovine aortic endothelial cells. J Cardiovasc Pharmacol 1999;33:671-677.
5. Benatti L, Fabbrini MS, Patrono C: Regulation of endothelin-1 biosynthesis. Ann NY Acad Sci 1994;714:109-121.
6. Minchenko A, Caro J: Regulation of endothelin-1 gene expression in human microvascular endothelial cells by hypoxia and cobalt: Role of hypoxia responsive element. Mol Cell Biochem 2000;208:53-62.
7. Lee SD, et al: Transforming growth factor-beta1 induces endothelin-1 in a bovine pulmonary artery endothelial cell line and rat lungs via cAMP. Pulm Pharmacol Ther 2000;13:257-265.
8. Maemura K, et al: Production of endothelin-1 in vascular endothelial cells is regulated by factors associated with vascular injury. Gerontology 1992;38(suppl 1):29-35.
9. Kourembanas S, et al: Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia. J Clin Invest 1993;92:99-104.
10. Lee ME, et al: Functional analysis of the endothelin-1 gene promoter. Evidence for an endothelial cell-specific cis-acting sequence. J Biol Chem 1990;265:10446-10450.
11. Lee ME, et al: Expression of the potent vasoconstrictor endothelin in the human central nervous system. J Clin Invest 1990;86:141-147.
12. Lee ME, et al: Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells. J Biol Chem 1991;266:16188-16192.
13. Lee ME, et al: Regulation of endothelin-1 gene expression by Fos and Jun. J Biol Chem 1991;266:19034-19039.
14. Kawana M, et al: Cooperative interaction of GATA-2 and AP1 regulates transcription of the endothelin-1 gene. Mol Cell Biol 1995;15:4225-4231.
15. Sawhney N, et al: Inhibition of proliferation by heparin and expression of p53 in cultured human vascular smooth muscle cells. J Hum Hypertens 1997;11:611-614.
16. Kohno M, et al: Heparin inhibits human coronary artery smooth muscle cell migration. Metabolism 1998;47:1065-1069.
17. Dilley RJ, Nataatmadja MI: Heparin inhibits mesenteric vascular hypertrophy in angiotensin II-infusion hypertension in rats. Cardiovasc Res 1998;38:247-255.
18. Ragazzi E, Chinellato A: Heparin: Pharmacological potentials from atherosclerosis to asthma. Gen Pharmacol 1995;26:697-701.
19. Shulman AG: Heparin and atherosclerosis: An investigative report on the treatment of atherosclerosis. Biomed Pharmacother 1990;44:303-306.
20. Engelberg H: Heparin and atherosclerosis. A review of old and recent findings. Am Heart J 1980;99:359-372.
21. Vasdev S, Prabhakaran V, Sampson CA: Heparin lowers blood pressure and vascular calcium uptake in hypertensive rats. Scand J Clin Lab Invest 1991;51:321-327.
22. Susic D, Mandal AK, Kentera D: Heparin lowers the blood pressure in hypertensive rats. Hypertension 1982;4:681-685.
23. Pukac LA, et al: Heparin inhibits c-fos and c-myc mRNA expression in vascular smooth muscle cells. Cell Regul 1990;1:435-443.
24. Pukac LA, Ottlinger ME, Karnovsky MJ: Heparin suppresses specific second messenger pathways for protooncogene expression in rat vascular smooth muscle cells. J Biol Chem 1992;267:3707-3711.
25. Wright TC Jr, et al: Heparin suppresses the induction of c-fos and c-myc mRNA in murine fibroblasts by selective inhibition of a protein kinase C-dependent pathway. Proc Natl Acad Sci USA 1989;86:3199-3203.
26. Imai T, et al: Heparin has an inhibitory effect on endothelin-1 synthesis and release by endothelial cells. Hypertension 1993;21:353-358.
27. Imai T, Hirata Y, Marumoand F: Heparin inhibits endothelin-1 and proto-oncogene c-fos gene expression in cultured bovine endothelial cells. J Cardiovasc Pharmacol 1993;22(suppl 8):S49-S52.
28. Castellot JJ Jr, et al: Inhibition of vascular smooth muscle cell growth by endothelial cell-derived heparin. Possible role of a platelet endoglycosidase. J Biol Chem 1982;257:11256-11260.
29. Yokokawa K, et al: Heparin suppresses endothelin-1 peptide and mRNA expression in cultured endothelial cells of spontaneously hypertensive rats. J Am Soc Nephrol 1994;4:1683-1689.
30. Yokokawa K, et al: Effect of heparin on endothelin-1 production by cultured human endothelial cells. J Cardiovasc Pharmacol 1993;22(suppl 8):S46-S48.
31. Chomczynski P, Sacchi N: Single step method of isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-159.
32. Lee ME, Bloch KD, Clifford JA, Quertermous T: Functional analysis of the endothelin-1 gene promoter. J Biol Chem 1990;265:10446-10450.
33. Rossi GP, et al: Interactions between endothelin-1 and the renin-angiotensin-aldosterone system. Cardiovasc Res 1999;43:300-307.
34. Masaki T, et al: Molecular and cellular mechanism of endothelin regulation. Implications for vascular function. Circulation 1991;84:1457-1468.
35. Yokota J, et al: Retinoic acid suppresses endothelin-1 gene expression at the transcription level in endothelial cells. Atherosclerosis 2001;159:491-496.
36. Davis RJ: Transcriptional regulation by MAP kinases. Mol Reprod Dev 1995;42:459-467.
37. Daum G, et al: Diverse effects of heparin on mitogen-activated protein kinase-dependent signal transduction in vascular smooth muscle cells. Circ Res 1997;81:17-23.