Down-regulation of the sodium channel Nav1.1 α-subunit following focal ischemic brain injury in rats: In situ hybridization and immunohistochemical analysis

Life Sciences

Volumn 77, Issue 10, 2005, Pages 1116-1129

  Yao, C ^a   Williams, A J ^a   Hartings, J A ^a   Lu, X C M ^a   Tortella, F C ^a   Dave, J R ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

Ischemia; MCAo; Middle cerebral artery occlusion; Reperfusion; Voltage gated sodium channel

Indexed keywords

MESSENGER RNA; SODIUM; SODIUM CHANNEL;

ALPHA CHAIN; ANIMAL MODEL; ARTICLE; BEHAVIOR; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN TISSUE; CELL COUNT; CONTROLLED STUDY; DOWN REGULATION; HEMISPHERE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; INFORMATION PROCESSING; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL; NONHUMAN; OPTICAL DENSITY; PROTEIN BLOOD LEVEL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RAT; REPERFUSION;

ANIMALS; BRAIN ISCHEMIA; CELL COUNT; DENSITOMETRY; DOWN-REGULATION; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NERVE TISSUE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RNA, MESSENGER; SODIUM CHANNELS;

EID: 20644467458     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2005.02.008     Document Type: Article

References (30)

1. V.J. Auld, A.L. Goldin, D.S. Krafte, J. Marshall, J.M. Dunn, W.A. Catterall, H.A. Lester, N. Davidson, and R.J. Dunn A rat brain Na+ channel alpha subunit with novel gating properties Neuron 1 1988 449 461
2. A.R. Cantrell, and W.A. Catterall Neuromodulation of Na+ channels: an unexpected form of cellular plasticity Nature Reviews Neuroscience 2 2001 397 407
3. A. Carter Voltage-dependent sodium channels and excitatory amino acids Amino Acids 14 1998 141 142
4. J.R. Dave, C. Yao, J.R. Moffett, R. Berti, M. Koenig, and F.C. Tortella Down regulation of sodium channel Na(v)1.1 expression by veratridine and its reversal by a novel sodium channel blocker, RS100642, in primary neuronal cultures Neurotoxicity Research 5 2003 213 220
5. P. Emson, and M. Gait In situ hybridization with biotinylated probes D.G. Wilkinson In Situ Hybridization A Practical Approach 1992 Oxford Univ. Press 45 59
6. T. Fujiwara, T. Sugawara, E. Mazaki-Miyazaki, Y. Takahashi, K. Fukushima, M. Watanabe, K. Hara, T. Morikawa, K. Yagi, K. Yamakawa, and Y. Inoue Mutations of sodium channel alpha subunit type 1 (SCN1A) in intractable childhood epilepsies with frequent generalized tonic-clonic seizures Brain 126 2003 531 546
7. B. Gong, K.J. Rhodes, Z. Bekele-Arcuri, and J.S. Trimmer Type I and type II Na(+) channel alpha-subunit polypeptides exhibit distinct spatial and temporal patterning, and association with auxiliary subunits in rat brain Journal of Comparative Neurology and Psychology 412 1999 342 352
8. D. Greenbaum, C. Colangelo, K. Williams, and M. Gerstein Comparing protein abundance and mRNA expression levels on a genomic scale Genome Biology 4 2003 29
9. S.M. Hsu, L. Raine, and H. Fanger Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures Journal of Histochemistry and Cytochemistry 29 1981 577 580
10. J.P. Klein, D.S. Khera, H. Nersesyan, E.Y. Kimchi, S.G. Waxman, and H. Blumenfeld Dysregulation of sodium channel expression in cortical neurons in a rodent model of absence epilepsy Brain Research 1000 2004 102 109
11. C. Lossin, D.W. Wang, T.H. Rhodes, C.G. Vanoye, and A.L. George Jr. Molecular basis of an inherited epilepsy Neuron 34 2002 877 884
12. X. Lu, F. Tortella, H. Ved, G. Garcia, and J. Dave Neuroprotective role of c-fos antisense oligonucleotide: in vitro and in vivo studies Neuroreport 8 1997 2925 2929
13. L. Martin, N. Al-Abdulla, A. Brambrink, J. Kirsch, F. Sieber, and C. Portera-Cailliau Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: a perspective on the contributions of apoptosis and necrosis Brain Research Bulletin 46 1998 281 309
14. R.J. Mullen, C.R. Buck, and A.M. Smith NeuN, a neuronal specific nuclear protein in vertebrates Development 116 1992 201 211
15. J.C. Mulley, I.E. Scheffer, S. Petrou, and S.F. Berkovic Channelopathies as a genetic cause of epilepsy Current Opinion in Neurology 16 2003 171 176
16. R. Nabbout, E. Gennaro, B. Dalla Bernardina, O. Dulac, F. Madia, E. Bertini, G. Capovilla, C. Chiron, G. Cristofori, M. Elia, E. Fontana, R. Gaggero, T. Granata, R. Guerrini, M. Loi, L. La Selva, M.L. Lispi, A. Matricardi, A. Romeo, V. Tzolas, D. Valseriati, P. Veggiotti, F. Vigevano, L. Vallee, F. Dagna Bricarelli, A. Bianchi, and F. Zara Spectrum of SCN1A mutations in severe myoclonic epilepsy of infancy Neurology 60 2003 1961 1967
17. M. Noda, T. Ikeda, H. Suzuki, H. Takeshima, T. Takahashi, M. Kuno, and S. Numa Expression of functional sodium channels from cloned cDNA Nature 322 1986 826 828
18. S.D. Novakovic, R.M. Eglen, and J.C. Hunter Regulation of Na+ channel distribution in the nervous system Trends in Neuroscience 24 2001 473 478
19. F.M. Rollwagen, Z.Y. Yu, Y.Y. Li, and N.D. Pacheco IL-6 rescues enterocytes from hemorrhage induced apoptosis in vivo and in vitro by a bcl-2 mediated mechanism Clinical Immunology and Immunopathology 89 1998 205 213
20. v1.1 channels with mutations of severe myoclonic epilepsy in infancy display attenuated currents Epilepsy Research 54 2003 201 207
21. F. Tortella, P. Britton, A. Williams, X. Lu, and A. Newman Neuroprotection (focal ischemia) and neurotoxicity (electroencephalographic) studies in rats with AHN649, a 3-amino analog of dextromethorphan and low-affinity N-methyl-D-aspartate antagonist The Journal of Pharmacology and Experimental Therapeutics 291 1999 399 408
22. J. Urenjak, and T. Obrenovitch Neuroprotection-rationale for pharmacological modulation of Na(+)-channels Amino Acids 14 1998 151 158
23. L.A. Weiss, A. Escayg, J.A. Kearney, M. Trudeau, B.T. MacDonald, M. Mori, J. Reichert, J.D. Buxbaum, and M.H. Meisler Sodium channels SCN1A, SCN2A and SCN3A in familial autism Molecular Psychiatry 8 2003 186 194
24. A. Williams, J. Dave, J. Phillips, Y. Lin, R. McCabe, and F. Tortella Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies The Journal of Pharmacology and Experimental Therapeutics 294 2000 378 386
25. A. Williams, X.-C. Lu, J. Hartings, and F. Tortella Neuroprotection assessment by topographic electroencephalographic analysis: effects of a sodium channel blocker to reduce polymorphic delta activity following ischaemic brain injury in rats Fundamental & Clinical Pharmacology 17 2003 581 593
26. A. Williams, and F. Tortella Neuroprotective effects of the sodium channel blocker RS100642 and attenuation of ischemia-induced brain seizures in the rat Brain Research 932 2002 45 55
27. A.J. Williams, G. Ling, R. Berti, J.R. Moffett, C. Yao, X.M. Lu, J.R. Dave, and F.C. Tortella Treatment with the snail peptide CGX-1007 reduces DNA damage and alters gene expression of c-fos and bcl-2 following focal ischemic brain injury in rats Experimental Brain Research 153 2003 16 26
28. C. Yao, A. Williams, P. Cui, R. Berti, J. Hunter, F. Tortella, and J. Dave Differential pattern of expression of voltage-gated sodium channel genes following ischemic brain injury in rats Neurotoxicity Research 4 2002 67 75
29. C. Yao, A.J. Williams, X.C. Lu, R.A. Price, B.S. Cunningham, R. Berti, F.C. Tortella, and J.R. Dave The sodium channel blocker RS100642 reverses down-regulation of the sodium channel alpha-subunit Na(v) 1.1 expression caused by transient ischemic brain injury in rats Neurotoxicity Research 5 2003 245 253
30. F.H. Yu, R.E. Westenbroek, I. Silos-Santiago, K.A. McCormick, D. Lawson, P. Ge, H. Ferriera, J. Lilly, P.S. DiStefano, W.A. Catterall, T. Scheuer, and R. Curtis Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2 The Journal of Neuroscience 23 2003 7577 7585