Neuroprotection - Rationale for pharmacological modulation of Na+-channels

Amino Acids

Volumn 14, Issue 1-3, 1998, Pages 151-158

  Urenjak, J ^a,c   Obrenovitch, T P ^b,c  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

Energy deprivation; Ischaemia; Na+ channel blockers; Na+ channels; Neuroprotection; Traumatic brain injury

Indexed keywords

2,4 DIAMINO 5 (2,3,5 TRICHLOROPHENYL)PYRIMIDINE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; ANTICONVULSIVE AGENT; CALCIUM ION; CARBAMAZEPINE; LAMOTRIGINE; LIDOCAINE; LOCAL ANESTHETIC AGENT; PHENYTOIN; PROCAINE; RILUZOLE; SIPATRIGINE; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; SODIUM ION;

BRAIN INJURY; BRAIN ISCHEMIA; BRAIN OXYGEN CONSUMPTION; CALCIUM HOMEOSTASIS; CONFERENCE PAPER; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SODIUM TRANSPORT;

EID: 0031985380     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01345256     Document Type: Conference Paper

References (67)

1. Ames III A (1997) Energy requirements of brain function: when is energy limiting? In: Beal MF, Howell N, Bodis-Wollner I (eds) Mitochondria and free radicals in neurodegenerative diseases. Wiley-Liss, Baltimore, pp 17-27
2. + transport. J Neurosci 12: 840-853
3. Artru F, Terrier A, Tixier S, Jourdan Ch, Deleuze R (1991) The use of intravenous lidocaine in neuro-anesthesia and neuro-intensive care. Agressol 32: 439-443
4. Astrup J (1982) Energy-requiring cell functions in the ischemic brain. Their critical supply and possible inhibition in protective therapy. J Neurosurg 56: 482-487
5. Boening JA, Kass IS, Cottrell JE, Chambers G (1989) The effect of blocking sodium influx on anoxic damage in the rat hippocampal slice. Neuroscience 33: 263-268
6. + channels: local anesthetics, antiarrhytmics and anticonvulsants. Trends Pharmacol Sci 8: 57-65
7. Cherubini E, Ben-Ari Y, Krnjevic K (1989) Anoxia produces smaller changes in synaptic transmission, membrane potential, and input resistance in immature rat hippocampus. J Neurophysiol 62: 882-895
8. Cheung H, Kamp D, Harris E (1992) An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels. Epilepsy Res 13: 107-112
9. Cummins TR, Xia Y, Haddad GG (1994) Functional properties of rat and human neocortical voltage-sensitive sodium currents. J Neurophysiol 71: 1052-1064
10. Dargent B, Couraud F (1990) Down-regulation of voltage-dependent sodium channels initiated by sodium influx in developing neurons. Proc Natl Acad Sci USA 87: 5907-5911
11. Douglas SM, Panizzon KL, Wallis RA (1996) Sodium channel blockers protect against traumatic neuronal injury in the adult rat spinal cord. Soc Neurosci Abstr 22: 230
12. Edwards RA, Lutz PL, Baden DG (1989) Relationship between energy expenditure and ion channel density in the turtle and rat brain. Am J Physiol 257 (6 Pt 2): R1354-R1358
13. Erecinska M, Silver IA (1989) ATP and brain function. J Cereb Blood Flow Metab 9: 2-19
14. Evans DE, Kobrine AI, Legrys DC, Bradley ME (1984) Protective effect of lidocaine in acute cerebral ischemia induced by air embolism. J Neurosurg 60: 257-263
15. Fern R, Ransom BR, Stys PK, Waxman SG (1993) Pharmacological protection of CNS white matter during anoxia: actions of phenytoin, carbamazepine and diazcpam. J Pharmacol Exp Ther 266: 1549-1555
16. Friedman JE, Haddad GG (1994) Removal of extracellular sodium prevents anoxia-induced injury in freshly dissociated rat CA1 hippocampal neurons. Brain Res 641: 57-64
17. Gilland E, Malgorzata P-S, Andiné P, Bona E, Hagberg H (1994) Hypoxic-ischemic injury in the neonatal rat brain: effects of pre- and post-treatment with the glutamate release inhibitor BW1003C87. Brain Res Dev Brain Res 83: 79-84
18. Ginsberg MD, Sternau LL, Globus MY-T, Dietrich WD, Busto R (1992) Therapeutic modulation of brain temperature: relevance to ischemic brain injury. Cerebrovasc Brain Metab Rev 4: 189-225
19. Graham SH, Chen J, Sharp FR, Simon RP (1993) Limiting injury by inhibition of excitatory amino acid release. J Cereb Blood Flow Metab 13: 88-97
20. Graham SH, Chen J, Lan J, Leach MJ, Simon RP (1994) Neuroprotective effects of a use-dependent blocker of voltage dependent sodium channels, BW619C89, in rat middle cerebral artery occlusion. J Pharmacol Exp Ther 269: 854-859
21. Hakim AM, Shoubridge EA (1989) Cerebral acidosis in focal ischemia. J Cereb Blood Flow Metab 1: 115-119
22. Hansen AJ (1985) Effect of anoxia on ion distribution in the brain. Physiol Rev 65: 101-148
23. Hoehn K, Watson TWJ, MacVitar BA (1993) A novel tetrodotoxin-insensitive, slow sodium current in striatal and hippocampal neurons. Neuron 10: 543-552
24. Kempski O, Staub F, v Rosen F, Zimmer M, Neu A, Baethmann A (1988) Molecular mechanisms of glial cell swelling in vitro. Neurochem Path 9: 109-125
25. Kozlowski DA, James DC, Schallert T (1996) Use-dependent exaggeration of neuronal injury after unilateral sensorimotor cortex lesions. J Neurosci 16: 4776-4786
26. Lang DG, Wang CM, Cooper BR (1993) Lamotrigine, phenytoin and carbamazepine interactions on the sodium current present in N4TG1 mouse neuroblastoma cells. J Pharmacol Exp Ther 266: 829-835
27. Leach MJ, Marden CM, Miller AA (1986) Pharmacological studies on Lamotrigine, a novel antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia 27: 490-497
28. Leach MJ, Swann JH, Eisenthal D, Dopson M, Nobbs M (1993) BW619C89, a glutamate release inhibitor, protects against focal cerebral ischaemic damage. Stroke 24: 1063-1067
29. Lees G, Leach MJ (1993) Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neuroglial cultures from rat cortex. Brain Res 612: 190-199
30. Lekieffre D, Meldrum BS (1993) The pyrimidine-derivative, BW1003C87, protects CA1 and striatal neurons following transient severe forebrain ischaemia in rats. A microdialysis and histological study. Neuroscience 56: 93-99
31. Lucas LF, West CA, Rigor BM, Schurr A (1989) Protection against cerebral hypoxia by local anesthetics: a study using brain slices. J Neurosci Meth 28: 47-50
32. Lysko PG, Yue TL, Gu JL, Webb CL, Feuerstein G (1993) Neuroprotective effects of tetrodotoxin in cultured cerebellar neurons and in gerbil global brain ischemia. Soc Neurosci Abstr 19: 286
33. Meldrum BS, Swan JH, Leach MJ, Millan MH, Gwinn R, Kadota K, Graham SH, Chen J, Simon RP (1992) Reduction of glutamate release and protection against ischaemic brain damage by BW1003C87. Brain Res 593: 1-6
34. Messenheimer JA (1995) Lamotrigine. Epilepsia 36 [Suppl 2]: S87-S94
35. Nicholls DG, Attwell D (1990) The release and uptake of excitatory amino acids. Trends Neurosci 11: 462-468
36. Obrenovitch TP (1997) Sodium and potassium channel modulators: their role in neuro-protection. In: Cross AJ, Green AR (eds) Neuroprotective agents and cerebral ischaemia. Academic Press, London, pp 109-135
37. Obrenovitch TP, Urenjak J (1997) Actions of riluzole in animal models of CNS ischaemia and trauma. Rev Contemp Pharmacother 8: 227-235
38. Obrenovitch TP, Sarna GS, Symon L (1990a) Ionic homeostasis and neurotransmitter changes in ischaemia. In: Krieglstein J, Oberpichler H (eds) Pharmacology of cerebral ischemia 1990. Wissenschaftliche Verlagsgesellschaft, Stuttgart, pp 97-112
39. Obrenovitch TP, Scheller D, Matsumoto T, Tegtmeier F, Höller M, Symon L (1990b) Rapid redistribution of hydrogen ions is associated with depolarization and repolarization subsequent to cerebral ischaemia-reperfusion. J Neurophysiol 64: 1125-1133
40. Okiyama K, Smith DH, Gennarelli TA, Simon RP, Leach M, McIntosh TK (1995) The sodium channel blocker and glutamate release inhibitor BW1003C87 and magnesium attenuate regional cerebral edema following experimental brain injury in the rat. J Neurochem 64: 802-809
41. Pérez-Pinzón MA, Rosenthal M, Sick TJ, Lutz PL, Pablo J, Mash D (1992) Downregulation of sodium channels during anoxia: a putative survival strategy of turtle brain. Am J Physiol 262: R712-R715
42. Prenen GHM, Go GK, Postema F, Zuiderveen F, Korf J (1988) Cerebral cation shifts in hypoxic-ischemic brain damage are prevented by the sodium channel blocker tetrodotoxin. Exp Neurol 99: 118-132
43. Rasool N, Faroqui M, Rubinstein, EH (1990) Lidocaine accelerates neuroelectrical recovery after incomplete global ischemia in rabbits. Stroke 21: 929-935
44. Rataud J, Debarnot F, Mary V, Pratt J, Stutzmann J-M (1994) Comparative study of voltage-sensitive sodium channel blockers in focal ischaemia and electric convulsions in rodents. Neurosci Lett 172: 19-23
45. Rothman SM (1985) The neurotoxicity of excitatory amino acids is produced by passive chloride influx. J Neurosci 5: 1483-1489
46. Schulz JB, Matthews RT, Henshaw DR, Beal MF (1996) Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases. Neuroscience 71: 1043-1048
47. Siesjö BK, Bengtsson F (1989) Calcium fluxes, calcium antagonists and calcium-related pathology in brain ischemia, hypoglycemia and spreading depression: a unifying hypothesis. J Cereb Blood Flow Metab 9: 127-140
48. Silver IA, Deas J, Erecinska M (1997) Ion homeostasis in brain cells: differences in intracellular ion responses to energy limitation between cultured neurons and glial cells. Neuroscience 78: 589-601
49. Skilling SR, Smullin DH, Beitz AJ, Larson AA (1988) Extracellular amino acid concentrations in the dorsal spinal cord of freely moving rats following veratridine and nociceptive stimulation. J Neurochem 51: 127-132
50. Smith SE, Meldrum BS (1995) Cerebroprotective effect of lamotrigine after focal ischemia in rats. Stroke 26: 117-122
51. Smith SE, Lekieffre D, Sowinski P, Meldrum BS (1993) Cerebroprotective effect of BW619C89 after focal or global cerebral ischaemia in the rat. Neuroreport 4: 1339-1342
52. Spetzler RF, Hadley MN (1989) Protection against cerebral ischemia: the role of barbiturates. Cerebrovasc Brain Metabol Rev 1: 212-229
53. 2+ exchanger. J Neurosci 12:430-439
54. Sun F-Y, Faden AI (1995) Neuroprotective effect of 619C89, a use-dependent sodium channel blocker, in rat traumatic brain injury. Brain Res 673: 133-140
55. + currents that fail to inactivate. Trends Neurosci 16: 455-460
56. +-channels: a rational and effective strategy against ischemic brain damage. Pharmacol Rev 48: 21-67
57. + influx. Pharmacology 43: 26-35
58. Vornov JJ, Tasker RC, Coyle JT (1994) Delayed protection by MK-801 and tetrodotoxin in a rat organotypic hippocampal culture model of ischemia. Stroke 25: 457-465
59. 2+-mediated injury in myelinated CNS axons. Brain Res 644: 197-204
60. Wiard RP, Dickerson MC, Beek O, Norton R, Cooper BR (1995) Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia. Stroke 26: 466-472
61. Xia Y, Haddad GG (1993) Neuroanatomical distribution and binding properties of saxitonin sites in the rat and turtle CNS. J Comp Neurol 330: 363-380
62. + channels in rat brain. J Comp Neurol 345: 279-287
63. + channels. Neuroscience 73: 951-962
64. + channels in rat hippocampal neurons. Eur J Physiol 430: 437-446
65. Xie Y, Dengler K, Zacharias E, Wilffert B, Tegtmeier F (1994) Effects of the sodium channel blocker tetrodotoxin (TTX) on cellular ion homeostasis in rat brain subjected to complete ischemia. Brain Res 652: 216-224
66. Yamasaki Y, Kogure K, Hara H, Ban H, Akaike N (1991) The possible involvement of tetrodotoxin-sensitive ion channels in ischemic neuronal damage in the rat hippocampus. Neurosci Lett 121: 251-254
67. Young AM, Foley PM, Bradford HF (1990) Preloading in vivo: a rapid and reliable method for measuring gamma-aminobutyric acid and glutamate fluxes by microdialysis. J Neurochem 55: 1060-1063