Silencing nature's narcotics: Metabolic engineering of the opium poppy

Trends in Biotechnology

Volumn 23, Issue 7, 2005, Pages 331-333

  Page, Jonathan E ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; BIOMEDICAL ENGINEERING; BIOSYNTHESIS; DRUG PRODUCTS PLANTS; METABOLISM;

ANALGESIC ALKALOIDS; BIOSYNTHETIC PATHWAYS; METABOLIC ENGINEERING; NARCOTICS; OPIUM POPPY;

DRUG PRODUCTS;

ALKALOID; ANALGESIC AGENT; BUPRENORPHINE; NALOXONE; NARCOTIC AGENT; NATURAL PRODUCT; OPIATE; OXYCODONE; RETICULIN; THEBAINE;

BIOSYNTHESIS; CHEMICAL ANALYSIS; DOWN REGULATION; DRUG ABUSE; METABOLIC ENGINEERING; PAPAVER SOMNIFERUM; PLANT; PRIORITY JOURNAL; RNA INTERFERENCE; SHORT SURVEY;

ALKALOIDS; BENZYLISOQUINOLINES; GENETIC ENGINEERING; MORPHINE; OPIUM; PAPAVER; PLANTS, GENETICALLY MODIFIED;

PAPAVER SOMNIFERUM;

EID: 20644434709     PISSN: 01677799     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibtech.2005.05.001     Document Type: Short Survey

References (11)

1. P. Schiff Opium and its alkaloids Am. J. Pharm. Ed. 66 2002 186 194
2. P.M. Dewick Medicinal Natural Products: A Biosynthetic Approach 1997 Wiley
3. UN Office on Drugs and Crime World Drug Report 2004 UN Publications
4. R.S. Allen RNAi-mediated replacement of morphine with the nonnarcotic alkaloid reticuline in opium poppy Nat. Biotechnol. 22 2004 1559 1566
5. P.J. Facchini Alkaloid biosynthesis in plants: biochemistry, cell biology, molecular regulation, and metabolic engineering applications Annu. Rev. Plant Physiol. Plant Mol. Biol. 52 2001 29 66
6. T.M. Kutchan Molecular genetics of plant alkaloid biosynthesis G.A. Cordell The Alkaloids 1998 Academic Press 257 316
7. L. Zhang Engineering tropane biosynthetic pathway in Hyoscyamus niger hairy root cultures Proc. Natl. Acad. Sci. U. S. A. 101 2004 6786 6791
8. S.S. Mahmoud, and R.B. Croteau Metabolic engineering of essential oil yield and composition in mint by altering expression of deoxyxylulose phosphate reductoisomerase and menthofuran synthase Proc. Natl. Acad. Sci. U. S. A. 98 2001 8915 8920
9. B. Unterlinner Molecular cloning and functional expression of codeinone reductase: the penultimate enzyme in morphine biosynthesis in the opium poppy Papaver somniferum Plant J. 18 1999 465 475
10. C.A. Helliwell, and P.M. Waterhouse Constructs and methods for hairpin RNA-mediated gene silencing in plants Methods Enzymol. 392 2005 24 35
11. B.S. Winkel Metabolic channeling in plants Annu. Rev. Plant Biol. 55 2004 85 107