In vivo molecular imaging characterizes pulmonary gene expression during experimental lung transplantation

American Journal of Transplantation

Volumn 5, Issue 6, 2005, Pages 1216-1225

  Dharmarajan, Sekhar ^a   Hayama, Makio ^a   Kozlowski, James ^b   Ishiyama, Takaaki ^a   Okazaki, Mikio ^a   Factor, Phillip ^c   Patterson, G Alexander ^a   Schuster, Daniel P ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NONE   (United States)

Author keywords

Gene therapy; Lung transplantation; Molecular imaging

Indexed keywords

GREEN FLUORESCENT PROTEIN; THYMIDINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC IMAGING; ENZYME ACTIVITY; FUSION GENE; GENE EXPRESSION; GENE THERAPY; GENETIC TRANSFECTION; GRAFT REJECTION; HERPES SIMPLEX VIRUS 1; LUNG GRAFT REJECTION; LUNG TRANSPLANTATION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; REPORTER GENE; TRANSGENE;

ANIMALS; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GRAFT REJECTION; GREEN FLUORESCENT PROTEINS; GUANINE; HERPESVIRUS 1, HUMAN; LUNG; LUNG TRANSPLANTATION; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS; RATS, INBRED BN; RATS, INBRED F344; REPERFUSION INJURY; THYMIDINE KINASE; TIME FACTORS; TREATMENT OUTCOME;

EID: 20544461367     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2005.00847.x     Document Type: Article

References (33)

1. Hosenpud JD, Bennett LE, Keck BM, Boucek MM, Novick RJ. The Registry of the International Society for Heart and Lung Transplantation: eighteenth Official Report-2001. J Heart Lung Transplant 2001; 20: 805-815.
2. Bagley J, Iacomini J. Gene therapy progress and prospects: gene therapy in organ transplantation. Gene Ther 2003; 10: 605-611.
3. Wood KJ, Fry J. Gene therapy: potential applications in clinical transplantation. Expert Rev Mol Med 1999; 1999: 1-20.
4. Giannoukakis N, Thomson A, Robbins P. Gene therapy in transplantation. Gene Ther 1999; 6: 1499-1511.
5. Guillot C, Le Mauff B, Cuturi MC, Anegon I. Gene therapy in transplantation in the year 2000: moving towards clinical applications? Gene Ther 2000; 7: 14-19.
6. Chen D, Sung R, Bromberg JS. Gene therapy in transplantation. Transpl Immunol 2002; 9: 301-314.
7. Deng S, Brayman KL. Gene therapy strategies to facilitate organ transplantation. Mol Med Today 1999; 5: 400-405.
8. Tagawa T, Kozower BD, Kanaan SA et al. Tumor necrosis factor inhibitor gene transfer ameliorates lung graft ischemia-reperfusion injury. J Thorac Cardiovasc Surg 2003; 126: 1147-1154.
9. Itano H, Mora BN, Zhang W et al. Lipid-mediated ex vivo gene transfer of viral interleukin 10 in rat lung allotransplantation. J Thorac Cardiovasc Surg 2001; 122: 29-38.
10. Fischer S, Liu M, MacLean AA et al. In vivo transtracheal adenovirus-mediated transfer of human interleukin-10 gene to donor lungs ameliorates ischemia-reperfusion injury and improves early posttransplant graft function in the rat. Hum Gene Ther 2001; 12: 1513-1526.
11. Tagawa T, Suda T, Daddi N et al. Low-dose endobronchial gene transfer to ameliorate lung graft ischemia-reperfusion injury. J Thorac Cardiovasc Surg 2002; 123: 795-802.
12. Kanaan SA, Kozower BD, Suda T et al. Intratracheal adenovirus-mediated gene transfer is optimal in experimental lung transplantation. J Thorac Cardiovasc Surg 2002; 124: 1130-1136.
13. Cassivi SD, Liu M, Boehler A et al. Transgene expression after adenovirus-mediated retransfection of rat lungs is increased and prolonged by transplant immunosuppression. J Thorac Cardiovasc Surg 1999; 117: 1-7.
14. Cassivi SD, Liu M, Boehler A et al. Transplant immunosuppression increases and prolongs transgene expression following adenovirus-mediated transfection of rat lungs. J Heart Lung Transplant 2000; 19: 984-994.
15. Suda T, Tagawa T, Kanaan SA et al. Adenovirus encoding soluble tumor necrosis factor α receptor immunoglobulin prolongs gene expression of a cotransfected reporter gene in rat lung. J Thorac Cardiovasc Surg 2003; 126: 1155-1161.
16. Schuster DP, Kovacs A, Garbow J, Piwnica-Worms D. Recent advances in imaging the lungs of intact small animals. Am J Respir Cell Mol Biol 2004; 30: 129-138.
17. Blasberg RG, Tjuvajev JG. Molecular-genetic imaging: current and future perspectives. J Clin Invest 2003; 111: 1620-1629.
18. Richard J-C, Zhou Z, Ponde DE et al. Imaging pulmonary gene expression with positron emission tomography. Am J Respir Crit Care Med 2003; 167: 1257-1263.
19. Richard J-C, Factor P, Welch LC, Schuster DP. Imaging the spatial distribution of transgene expression in the lungs with positron emission tomography. Gene Ther 2003; 10: 2074-2080.
20. Richard J-C, Zhou Z, Chen DL et al. Quantitation of pulmonary transgene expression with PET imaging. J Nucl Med 2004; 45: 644-654.
21. Richard J-C, Factor P, Ferkol T, Ponde DE, Zhou Z, Schuster DP. Repetitive imaging of reporter gene expression in the lung. Mol Imaging 2003; 2: 342-349.
22. Luker GD, Sharma V, Pica CM et al. Noninvasive imaging of protein-protein interactions in living animals. Proc Natl Acad Sci USA 2002; 99: 6961-6966.
23. Factor P, Mendez M, Mutlu GM, Dumasius V. Acute hyperoxic lung injury does not impede adenoviral-mediated alveolar gene transfer. Am J Respir Crit Care Med 2002; 165: 521-526.
24. Factor P, Dumasius V, Saldias F, Brown LA, Sznajder JI. Adenovirus-mediated transfer of an Na+/K+-ATPase beta1 subunit gene improves alveolar fluid clearance and survival in hyperoxic rats. Hum Gene Ther 2000; 11: 2231-2242.
25. Mizuta T, Kawaguchi A, Nakahara K, Kawashima Y. Simplified rat lung transplantation using cuff technique. J Thorac Cardiovasc Surg 1989; 97: 578-581.
26. Ponde DE, Dence CS, Schuster DP, Welch MJ. Rapid and reproducible radiosynthesis of [18F] FHBG. Nucl Med Biol 2004; 31: 133-138.
27. De Perrot M, Fischer S, Liu M et al. Impact of human interleukin-10 on vector-induced inflammation and early graft function in rat lung transplantation. Am J Respir Cell Mol Biol 2003; 28: 616-625.
28. Massoud TF, Gambhir SS. Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes Dev 2003; 17: 545-580.
29. Daddi N, Kanaan SA, Suda T et al. Recipient intramuscular administration of naked plasmid TGF-beta1 attenuates lung graft reperfusion injury. J Heart Lung Transplant 2003; 22: 1323-1334.
30. Cassivi SD, Cardella JA, Fischer S, Liu M, Slutsky AS, Keshavjee S. Transtracheal gene transfection of donor lungs prior to organ procurement increases transgene levels at reperfusion and following transplantation. J Heart Lung Transplant 1999; 18: 1181-1188.
31. Martins SC, de Perrot M, Imai Y et al. Endoscopic delivery of adenoviral-mediated human interleukin-10 gene to the donor improves post transplant lung function in a large animal model [abstract]. J Heart Lung Transplant 2002; 21: 131.
32. Itano H, Zhang W, Ritter JH et al. Endobronchial transfection of naked viral interleukin-10 gene in rat lung allotransplantation. Ann Thorac Surg 2001; 71: 1126-1133.
33. Suda T, D'Ovidio F, Daddi N, Ritter JH, Mohanakumar T, Patterson GA. Recipient intramuscular gene transfer of active transforming growth factor-β1 attenuates acute lung rejection. Ann Thorac Surg 2001; 71: 1651-1656.