Endostatin modulates VEGF-mediated barrier dysfunction in the retinal microvascular endothelium

Experimental Eye Research

Volumn 81, Issue 1, 2005, Pages 22-31

  Brankin, B ^a   Campbell, M ^a   Canning, P ^b   Gardiner, T A ^b   Stitt, A W ^b  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Blood retinal barrier; Endostatin; Evan's blue; Occludin; Tight junctions; VEGF

Indexed keywords

ENDOSTATIN; EVANS BLUE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; OCCLUDIN; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD RETINA BARRIER; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; ENDOTHELIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STATISTICAL SIGNIFICANCE; VASCULAR ENDOTHELIUM;

ANIMALS; BLOOD-RETINAL BARRIER; BLOTTING, WESTERN; CAPILLARY PERMEABILITY; CATTLE; CELLS, CULTURED; ENDOSTATINS; ENDOTHELIUM, VASCULAR; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; PHOSPHOPROTEINS; PHOSPHORYLATION; RECOMBINANT PROTEINS; RETINAL VESSELS; TIGHT JUNCTIONS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 20544447160     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2005.01.005     Document Type: Article

References (33)

1. D.A. Antonetti, A.J. Barber, L.A. Hollinger, E.B. Wolpert, and T.W. Gardner Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors J. Biol. Chem. 274 1999 23463 23467
2. A. Auricchio, K.C. Behling, A.M. Maguire, E.M. O'Connor, J. Bennett, J.M. Wilson, and M.J. Tolentino Inhibition of choroidal neovascularization by intravenous injection of adenoviral vectors expressing secretable endostatin Am. J. Pathol. 159 2002 313 320
3. M.S. Balda, J.M. Anderson, and K. Matter The SH3 domain of the tight junction protein ZO-1 binds to a serine protein kinase that phosphorylates a region C-terminal to this domain FEBS Lett. 399 1996 326 332
4. Barber, A.J., Antonetti, D.A., 2003. Mapping the blood vesseles with paracelluar permeability in the retinas od diabetic rats. Invest, Opthalmol, Vis. Sci, 44(12):5410-5416.
5. D.O. Bates, D. Lodwick, and B. Williams Vascular endothelial growth factor and microvascular permeability Microcirculation 6 1999 83 96 Review
6. M.A. Behzadian, L.J. Windsor, N. Ghaly, G. Liou, N.T. Tsai, and R.B. Caldwell VEGF-induced paracellular permeability in cultured endothelial cells involves urokinase and its receptor FASEB J. 17 2003 752 754
7. M.D. Carney, R.R. Paylor, J.G. Cunha-Vaz, L.M. Janpol, and M.E. Goldberg Iatrogenic choroidal neovascularisation in sickle cell retinopathy Ophthalmology 93 1986 1163 1168
8. J. Dixelius, M. Cross, T. Matsumoto, T. Sasaki, R. Timpl, and L. Claesson-Welsh Endostatin regulates endothelial cell adhesion and cytoskeletal organization Cancer Res. 62 2002 1944 1947
9. J. Dixelius, M. Cross, T. Matsumoto, and L. Claesson-Welsh Endostatin action and intracellular signalling:β-catenin as a potential target? Cancer Lett. 196 2003 1 12
10. H. Dorchy Characterisation of early stages of diabetic retinopathy Diabetes Care 16 1993 1212 1214
11. J.F. Dye, L. Leach, P. Clark, J.A. Firth, and A.M.P. Cyclic and acidic fibroblast growth factor have opposing effects on tight and adherens junctions in microvascular endothelial cells in vitro Microvasc. Res. 62 2001 94 113
12. S. Esser, K. Wolburg, H. Wolburg, G. Breier, T. Kurzchalia, and W. Risau Vascular endothelial growth factor induces endothelial fenestrations in vitro J. Cell Biol. 140 1998 947 959
13. A.L. Feldman, H.R. Alexander Jr, J.C. Yang, W.M. Linehan, R.A. Eyler, M.S. Miller, S.M. Steinberg, and S.K. Libutti Prospective analysis of circulating endostatin levels in patients with renal cell carcinoma Cancer 95 2002 1637 1643
14. D. Feng, J.A. Nagy, J. Hipp, H.F. Dvorak, and A.M. Dvorak Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin J. Exp. Med. 183 1996 1981 1986
15. H. Funatsu, H. Yamashita, H. Noma, H. Mochizaki, T. Mimura, T. Ikeda, and S. Hori Outcome of vitreous surgery and the balance between vascular endothelial growth factor and endostatin Invest. Ophthalmol. Vis. Sci. 44 2003 1042 1047
16. L. Gonzalez-Mariscal, A. Betanzos, P. Nava, and B.E. Jaramillo Tight junction proteins Prog. Biophys. Mol. Biol. 81 2003 1 44
17. W. Halfter, S. Dong, B. Schurer, and G.J. Cole Collagen XVIII is a basement membrane heparan sulfate proteoglycan J. Biol. Chem. 273 1998 25404 25412
18. N.S. Harhaj, and D.A. Antonetti Regulation of tight junctions and loss of barrier function in pathophysiology Int. J. Biochem. Cell Biol. 3697 2004 1206 1237
19. Y.M. Kim, S. Hwang, Y.M. Kim, B.J. Pyun, T.Y. Kim, S.T. Lee, Y.S. Gho, and Y.G. Kwon Endostatin blocks vascular endothelial growth factor-mediated signaling via direct interaction with KDR/Flk-1 J. Biol. Chem. 277 2002 27872 27879
20. H. Kurihara, J.M. Anderson, and M.G. Farquhar Increased Tyr phosphorylation of ZO-1 during modification of tight junctions between glomerular foot processes Am. J. Physiol. 268 1995 514 524
21. L. Le Gat, K. Gogat, C. Bouquet, M. Saint-Geniez, D. Darland, L. Van Den Berghe, D. Marchant, A. Provost, M. Perricaudet, M. Menasche, and M. Abitbol In vivo adenovirus-mediate delivery of a uPA/uPAR antagonist reduces retinal neovascularisation in a mouse model of retinopathy Gene Ther. 10 2003 2098 2103
22. G. Maik-Rachline, S. Shaltiel, and R. Seger Extracellular phosphorylation converts pigment epithelium-derived factor from a neurotrophic to an antiangiogenic factor Blood 2004
23. K. Mori, A. Ando, P. Gehlbach, D. Nesbitt, K. Takahashi, D. Goldsteen, M. Penn, C.T. Chen, K. Mori, M. Melia, S. Phipps, P. Moffat, K. Brazzell, D. Liau, K.H. Dixon, and P.A. Campochiaro Inhibition of choroidal neovascularization by intravenous injection of adenoviral vectors expressing secretable endostatin Am. J. Pathol. 159 2001 313 320
24. M.S. O'Reilly, T. Boehm, Y. Shing, N. Fukai, G. Vasios, W.S. Lane, E. Flynn, J.R. Birkhead, B.R. Olsen, and J. Folkman Endostatin: an endogenous inhibitor of angiogenesis and tumor growth Cell 88 1997 277 285
25. A.W. Stitt, G.A. Burke, F. Chen, C.B. McMullen, and H. Vlassara Advanced glycation end-product receptor interactions on microvascular cells occur within caveolin-rich membrane domains FASEB J. 14 2000 2390 2392
26. K. Takahashi, Y. Saishin, Y. Saishin, R. Lima Silva, Y. Oshima, S. Oshima, M. Melia, B. Paszkiet, D. Zerby, M. Kadan, G. Liau, M. Kaleko, S. Connelly, T. Luo, and P.A. Campochiaro Intraocular expression of endostatin reduces VEGF-induced retinal vascular permeability, neovascularisation, and retinal detachment FASEB J. 17 2003 896 898
27. K. Takata, H. Hirano, and M. Kasahara Transport of glucose across the blood-tissue barriers Int. Rev. Cytol. 172 1997 1 53 Review
28. A. Toker, and L.C. Cantley Signalling through the lipid products of phosphoinositide-3-OH kinase Nature 387 1997 673 676 Review
29. M. Tretiach, D. van Driel, and M.C. Gillies Transendothelial electrical resistance of bovine capillary endothelial cells is influenced by cell growth patterns: an ultrastructural study Clin. Exp. Ophthalmol. 31 2003 348 353
30. S.A. Vinores, M. Kuchlem, N.L. Derevjank, J.D. Henderer, J. Mahlow, W.R. Green, and P.A. Campochiaro Blood-retinal barrier breakdown in retinitis pigmentosa: light and electron microscopic immunolocalisation Histol. Histopathol. 10 1995 913 923
31. S.A. Vinores, N.L. Derevjank, H. Ozaki, N. Okamoto, and P.A. Campochiaro Cellular mechanisms of blood-retinal barrier dysfunction in macular edema Doc. Ophthalmol. 97 1999 217 228
32. Wong Phosphorylation of occludin correlates with occludin localization and function at the tight junction Am. J. Physiol. 273 1997 1859 1867
33. Q. Xu, T. Qaum, and A.P. Adamis Sensitive blood-retinal barrier breakdown quantitation using Evans blue Invest. Ophthalmol. Vis. Sci. 42 2001 789 794