Synthesis of novel dihydrofuro[b]-pyridinone derivatives: Oxidation coupling of 3-hydroxy-4(1H)-pyridinone with β-dicarbonyl compounds

Tetrahedron Letters

Volumn 46, Issue 30, 2005, Pages 5085-5088

  Pei, Li Xia ^a   Huang, Shi Liang ^a   Shen, Yu Dong ^a   An, Lin Qun ^a   Huang, Zhi Shu ^a   Li, Yue Ming ^b   Gu, Lian Quan ^a   Bu, Xian Zhang ^a   Chan, Albert S C ^b  

^a SUN YAT SEN UNIVERSITY   (China)

^b HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

Dicarbonyl compounds; Dihydrofuro b pyridinone; Oxidation coupling; Pyridinone

Indexed keywords

ANILINE DERIVATIVE; CARBONYL DERIVATIVE; PYRIDONE DERIVATIVE; THIOL DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; OXIDATION;

EID: 20544439835     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2005.05.078     Document Type: Article

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23. 6, 75 MHz): 9.1, 21.0, 26.4, 69.4, 90.3, 106.2, 112.2, 117.2, 123.4, 134.8, 135.4, 153.1, 153.4, 158.8, 166.9, 180.9.
24. 2 = 0.1193 ([I > 2σ(I)]), 0.1267 (all data). Crystallographic data for the structures in this paper have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication numbers CCDC 262726. Copies of the data can be obtained, free of charge, on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK [fax: +44(0) 1223 336033 or e-mail: deposit@ccdc.cam.ac.uk.
25. 3), 5.24 (dd, J = 7.5 1.5 Hz, 1H, pyridinone ring), 7.74 (t, J = 7.2 Hz, 1H, pyridinone ring), 9.12 (br, 1H, NH).