Potential new antitumor agents from an innovative combination of camphorato, a ramification of traditional Chinese medicine, with a platinum moiety

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 14, 2005, Pages 3417-3422

  Wang, Lianhong ^a   Gou, Shaohua ^a   Chen, Yongjiang ^a   Liu, Yun ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Antitumor drugs; Camphoric acid; Platinum; TCM

Indexed keywords

ANTINEOPLASTIC AGENT; CAMPHOR; CARBOPLATIN; CISPLATIN; OXALIPLATIN; PLATINUM DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; COLON CARCINOMA; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; LEUKEMIA; LIVER CELL CARCINOMA; LUNG CARCINOMA; MALE; MOUSE; NONHUMAN; OVARY CARCINOMA;

ANIMALS; ANTINEOPLASTIC AGENTS; CAMPHOR; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; HUMANS; MALE; MEDICINE, CHINESE TRADITIONAL; MICE; MICE, NUDE; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; PLATINUM; STRUCTURE-ACTIVITY RELATIONSHIP; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 20544438626     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.05.025     Document Type: Article

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48. 2O, and then dried in vacuo to give cis-diiodo(diammine)platinum (II), cis-diiodo (diisopropylamine)platinum (II), cis-diiodo-di(2-methoxyethylamine)platinum (II), cis-diiodo [(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane] platinum (II), and cis-diiodo[(4S,5S)-4,5-bis(aminomethyl)-2-isopropyl-1,3- dioxolane] platinum (II). The yields in the above reactions were almost quantitative
49. 4 (6 mmol) in distilled water was added trans-1R,2R-diaminocyclohexane (DACH) (6 mmol) and the mixture was allowed to stir at 60°C under a nitrogen atmosphere for 8 h. The yellow precipitate was collected and washed successively with water, ethanol, and ether, and then dried in vacuo to give cis-dichloro(trans-1R,2R-cyclohexanediamine-N,N′)platinum (II). The yield was 95%
50. 2)