Cachexia in chronic kidney disease: A link to defective central nervous system control of appetite

Journal of Clinical Investigation

Volumn 115, Issue 6, 2005, Pages 1476-1478

  Mitch, William E ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b Nephrology Division   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; ALPHA INTERMEDIN; CHOLECYSTOKININ; GHRELIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; INTERLEUKIN 6; LEPTIN; MELANOCORTIN 4 RECEPTOR; NEUROPEPTIDE Y; PEPTIDE YY;

ANOREXIA; APPETITE; CACHEXIA; CENTRAL NERVOUS SYSTEM; CHRONIC KIDNEY DISEASE; FOOD INTAKE; HUNGER; HYPOTHALAMUS; INFLAMMATION; NEUROENDOCRINE SYSTEM; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SATIETY; SIGNAL TRANSDUCTION;

ANIMALS; ANOREXIA; CACHEXIA; CHRONIC DISEASE; HUMANS; HYPOTHALAMUS; KIDNEY DISEASES; MICE;

EID: 20444500884     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI25255     Document Type: Review

References (17)

1. Kopple, J.D., et al. 2000. Relationship between nutritional status and the glomerular filtration rate: results from the MDRD Study. Kidney Int. 57:1688-1703.
2. Mitch, W.E. 2002. Malnutrition: a frequent misdiagnosis for hemodialysis patients. J. Clin. Invest. 110:437-439. doi:10.1172/JC1200216494.
3. Mamoun, A.H., Sodersten, P., Anderstam, B., and Bergstrom, J. 1999. Evidence of splanchnic-brain signalling in inhibition of ingestive behaviour by middle molecules. J. Am. Soc. Nephrol. 10:309-314.
4. Cheung, W., et al. 2005. Role of leptin and melanocortin signaling in uremia-associated cachexia. J Clin. Invest. 115:1659-1665. doi:10.1172/JCI22521.
5. Schwartz, M.W., Woods, S.C., Porte, D., Seeley, R.J., and Baskin, D.G. 2000. Central nervous system control of food intake. Nature. 404:661-671.
6. Schwartz, M.W., and Morton, G.J. 2002. Keeping hunger at bay. Nature. 418:595-597.
7. Bruning, J.C., et al. 2000. Role of brain insulin receptor in control of body weight and reproduction. Science. 289:2122-2125.
8. Faggioni, R., Feingold, K.R., and Grunfeld, C. 2001. Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J. 15:2565-2571.
9. Don, B.R., Resales, L.M., Levine, N.W., Mitch, W.E., and Kaysen, G.A. 2001. Leptin is a negative acute phase protein in chronic hemodialysis patients. Kidney Int. 59:1114-1120.
10. Batterham, R.L., et al. 2002. Gut hormone PYY3-36 physiologically inhibits food intake. Nature. 418:650-654.
11. Cowley, M-A., et al. 2003. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron. 37:649-661.
12. Butler, A.A., et al. 2001. Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Nat. Neurosci. 4:605-611.
13. Minokoshi, Y., et al. 2004. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature. 428:569-574.
14. Marks, D.L., Ling, N., and Cone, R.D. 2001. Role of the central melanocortin system in cachexia. Cancer Res. 61:1432-1438.
15. Stephens, T., et al. 1995. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature. 377:530-532.
16. Dhiilo, W.S., and Bloom, S.R., 2001. Hypothalamic peptides as drug targets of obesity. Curr. Opin. Pharmacol. 1:651-655.
17. Meireles, C.L., Price, S.R., Pererira, A.M.L., Carvalhaes, J.T.A., and Mitch, W.E. 1999. Nutrition and chronic renal failure in rats: what is an optimal dietary protein? J. Am. Soc. Nephrol. 10:2367-2373.