The 4′,4′-difluoro analog of 5′-noraristeromycin: A new structural prototype for possible antiviral drug development toward orthopoxvirus and cytomegalovirus

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 14, 2005, Pages 4443-4449

  Roy, Atanu ^a   Schneller, Stewart W ^a   Keith, Kathy A ^b   Hartline, Caroll B ^b   Kern, Earl R ^b  

^a AUBURN UNIVERSITY   (United States)

^b University of Alabama at Birmingham   (United States)

Author keywords

Adenine; Antiviral; Carbocyclic nucleosides; Enantiodivergent

Indexed keywords

4 HYDROXY 2 CYCLOPENTEN 1 YLACETATE; 4' HYDROXY 5' NORARISTEROMYCIN; 5 (6 AMINO 9H PURIN 9 YL) 3,3 DIFLUOROCYCLOPENTANE 1,2 DIOL; ACETIC ACID DERIVATIVE; ANTIVIRUS AGENT; CIDOFOVIR; GANCICLOVIR; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG; 5' NORARISTEROMYCIN; 5'-NORARISTEROMYCIN; ADENOSINE; DRUG DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; COWPOX; CYTOMEGALOVIRUS; CYTOTOXICITY; ENANTIOMER; HUMAN; HUMAN CELL; ORTHOPOXVIRUS; VACCINIA; ANIMAL; CELL CULTURE; CELL DIVISION; CERCOPITHECUS; CHEMISTRY; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; MICROBIOLOGICAL EXAMINATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; VERO CELL; VIRUS CULTURE;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5; ORTHOPOX VIRUS; ORTHOPOXVIRUS; VACCINIA;

ADENOSINE; ANIMALS; ANTIVIRAL AGENTS; CELL DIVISION; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CYTOMEGALOVIRUS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; ORTHOPOXVIRUS; PLAQUE ASSAY; VERO CELLS;

EID: 20444457155     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.04.044     Document Type: Article

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