Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous torasemide in rats

International Journal of Pharmaceutics

Volumn 298, Issue 1, 2005, Pages 38-46

  Lee, Dae Y ^a   Lee, Shin J ^a   Lee, Myung G ^a  

^a Seoul National University   (South Korea)

Author keywords

CYP2C11; Enzyme inducers or inhibitors; Pharmacokinetics; Rats; Torasemide

Indexed keywords

3 METHYLCHOLANTHRENE; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; CYTOCHROME P450 2C11; CYTOCHROME P450 2D1; CYTOCHROME P450 2E1; CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; CYTOCHROME P450 ISOENZYME; DEXAMETHASONE; ENZYME INDUCING AGENT; ISONIAZID; OXIDOREDUCTASE INHIBITOR; PHENOBARBITAL; PROADIFEN; QUININE; SULFAPHENAZOLE; TORASEMIDE; TROLEANDOMYCIN;

ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; DEXAMETHASONE; ENZYME INDUCTION; MALE; MEMBRANE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; STEROID 16-ALPHA-HYDROXYLASE; SULFONAMIDES;

EID: 20444435016     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.03.014     Document Type: Article

References (38)

1. M.P. Arlotto, A.J. Sonderfan, C.D. Klaassen, and A. Pakinson Studies on the pregnenolone-16-carbonitrile-inducible form of rat liver microsomal cytochrome P-450 and UDP-glucuronosyl transferase Biochem. Pharmacol. 36 1987 3859 3866
2. S.K. Bae, D.Y. Lee, A.K. Lee, J.W. Kwon, I. Lee, S.-J. Chung, S.G. Kim, C.-K. Shim, and M.G. Lee Effects of cysteine on the pharmacokinetics of intravenous torasemide in rats with protein-calorie malnutrition J. Pharm. Sci. 93 2004 2388 2398
3. W.L. Chiou Critical evaluation of the potential error in pharmacokinetic studies using the linear trapezoidal rule method for the calculation of the area under the plasma level-time curve J. Pharmacokinet. Biopharm. 6 1978 539 546
4. W.L. Chiou New calculation method for mean apparent drug volume of distribution and application to rational dosage regimen J. Pharm. Sci. 68 1979 1067 1069
5. W.L. Chiou New calculation method of mean total body clearance of drugs and its application to rational dosage regimens J. Pharm. Sci. 69 1980 90 91
6. M.K. Cho, Y.G. Kim, M.G. Lee, and S.G. Kim Suppression of rat hepatic cytochrome P450s by protein-calorie malnutrition: Complete or partial restoration by cysteine or methionine supplementation Arch. Biochem. Biophys. 372 1999 150 158
7. Y.M. Choi, S.H. Kim, and M.G. Lee Effect of phenobarbital and 3-methylcholanthrene pretreatment on the pharmacokinetics and pharmacodynamics of furosemide in rats J. Pharm. Sci. 80 1991 638 642
8. A.H. Conney Environmental factors influencing drug metabolism B.N. La Du H.G. Mandel E.L. Way Fundamentals of Drug Metabolism and Drug Disposition 1971 Williams & Wilkins Company Baltimore 269
9. M.A. Correia Appendix B. Rat and human liver cytochromes P450. Substrate and inhibitor specificities and functional markers P.R. Oritz de Montellano Cytochrome P450. Structure, Mechanism, and Biochemistry second ed. 1995 Plenum Press New York and London 607 630
10. Z. Dvorak, M. Modriansky, L. Pichard-Garcia, P. Balaguer, M.J. Vilarem, J. Ulrichova, P. Maurel, and J.M. Pascussi Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation Mol. Pharmacol. 64 2003 160 169
11. F.B. Eatman, W.A. Colburn, H.G. Boxenbaum, H.N. Posmanter, R.E. Weinfeld, R. Ronfeld, L. Weissman, J.D. Moore, M. Gibaldi, and S.A. Kaplan Pharmacokinetics of diazepam following multiple dose oral administration to healthy human subjects J. Pharmacokinet. Biopharm. 5 1977 481 494
12. B.C. Foster, S. Vandenhoek, J. Hana, A. Krantis, M.H. Akhtar, M. Bryan, J.W. Budzinski, A. Ramputh, and J.T. Arnason In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products Phytomedicine 10 2003 334 342
13. S. Gerbal-Chaloin, J.M. Pascussi, L. Pichard-Garcia, M. Daujat, F. Waechter, J.M. Fabre, N. Carrere, and P. Maurel Induction of CYP2C genes in human hepatocytes in primary culture Drug Metab. Dispos. 29 2001 242 251
14. M. Gibaldi, and D. Perrier Pharmacokinetics second ed. 1982 Marcel Dekker New York
15. J.R. Halpert Multiplicity of steroid-inducible cytochrome P-450 in rat liver microsomes Arch. Biochem. Biophys. 263 1988 59 68
16. A.H. Hammond, and J.R. Fry Involvement of cytochrome P450 2E1 in the toxicity of dichloropropanol to rat hepatocyte cultures Toxicology 118 1997 171 179
17. A. Kawamura, Y. Yoshida, N. Kimura, H. Oda, and A. Kakimuma Phosphorylation/dephosphorylation steps are crucial for the induction of CYP2B1 and CYP2B2 gene expression by phenobarbital Biochem. Biophys. Res. Commun. 264 1999 530 536
18. Kim, Y.C., 2005. Pharmacokinetic changes of drugs in rats with diabetes mellitus with respect to CYP isozymes changes. Ph.D. Thesis, Seoul National University, Seoul, Korea.
19. E.J. Kim, and M.G. Lee Pharmacokinetics and pharmacodynamics of intravenous torasemide in mutant Nagase analbuminemic rats Biopharm. Drug Dispos. 24 2003 27 35
20. S.H. Kim, Y.M. Choi, and M.G. Lee Pharmacokinetics and pharmacodynamics of furosemide in protein-calorie malnutrition J. Pharmacokinet. Biopharm. 21 1993 1 17
21. H. Knauf, and E. Mutschler Clinical pharmacokinetics and pharmacodynamics of torasemide Clin. Pharmacokinet. 34 1998 1 24
22. Lee, D.Y., Kim, J.Y., Kim, Y.C., Kwon, J.W., Kim, W.B., Lee, M.G. Dose-independent pharmacokinetics of torasemide after intravenous and oral administration to rats. Biopharm. Drug Dispos., in press.
23. D.F.V. Lewis P450 substrate specificity and metabolism Cytochromes P450 Structure, Function and Mechanism 1996 Talyor & Francis Bristol, PA p. 123
24. C. Liddle, A. Mode, C. Legraverend, and J.A. Gustafsson Constitutive expression and hormonal regulation of male sexually differentiated cytochrome P450 in primary cultured rat hepatocytes Arch. Biochem. Biophys. 298 1992 159 166
25. J.O. Miners, D.L.P. Rees, L. Valente, M.E. Veronese, and D.J. Birkett Human hepatic cytochrome P450 2C9 catlayzes the rate-limiting pathway of torasemide metabolism J. Pharmacol. Exp. Ther. 272 1995 1076 1081
26. M. Nakamura, E. Tanaka, S. Misawa, T. Shimada, S. Imaoka, and Y. Funae Trimethadione metabolism, a useful indicator for assessing hepatic drug-oxidizing capacity Biochem. Pharmacol. 47 1994 247 251
27. T. Ogiso, M. Iwaki, H. Tanaka, E. Kobayashi, T. Tanino, A. Sawada, and S. Uno Pharmacokinetic drug interactions between ampiroxicam and sulfaphenazole in rats Biol. Pharm. Bull. 22 1999 191 196
28. P.H. Ross, B.G. Ciosk, P. Kallweit, D. Kauczinski, and W.G. Hanstein Formation of ligand and metabolite complexes as a means for selective quantitation of cytochrome P450 isozymes Biochem. Pharmacol. 45 1993 2239 2250
29. D.E. Ryan, L. Ramanathan, S. Iida, and P.E. Thomas Characterization of a major form of rat hepatic microsomal cytochrome P-450 induced by isoniazid J. Biol. Chem. 260 1985 6385 6393
30. C.D. Scripture, and J.A. Pieper Clinical pharmacokinetics of fluvastatin Clin. Pharmacokinet. 40 2001 263 281
31. J.F. Sinclair, J.G. Szakacs, S.G. Wood, V.E. Kostrubsky, E.H. Jeffery, S.A. Wrighton, W.J. Bement, D. Wright, and P.R. Sinclair Acetaminophen hepatotoxicity precipitated by short-term treatment of rats with ethanol and isopentanol: Protection by triacetyloleandomycin Biochem. Pharmacol. 59 2000 445 454
32. M. Spatzenegger, Y. Horsmans, and R.K. Verbeeck Differential activities of CYP1A isozymes in hepatic and intestinal microsomes of control and 3-methylcholanthrene-induced rats Pharmacol. Toxicol. 86 2000 71 77
33. D.M. Tomkins, S.V. Otton, N. Joharchi, N.-Y. Li, R.F. Balster, R.F. Tyndale, and E.M. Sellers Effects of cytochrome P450 2D1 inhibition on hydrocodone metabolism and its behavioral consequences in rats J. Pharmacol. Exp. Ther. 280 1997 1374 1382
34. R.F. Tyndale, Y. Li, N.-Y. Li, E. Messina, S. Miksys, and E.M. Sellers Characterization of cytochrome P-450 2D1 activity in rat brain: High-affinity kinetics for dextromethorphan Drug Metab. Dispos. 27 1999 924 930
35. M. Unger, and A. Frank Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction Rapid Commun. Mass Spectrom. 18 2004 2273 2281
36. J.F. Williams, S. Lowitt, and A. Szentivanyi Effect of phenobarbital and 3-methylcholanthrene pretreatment on the plasma half-life and urinary excretion profile of theophylline and its metabolites in rats Biochem. Pharmacol. 28 1979 2935 2940
37. M. Wittner, A.D. Stefano, P. Wangemann, and R. Greger How do loop diuretics act? Drugs 41 1991 1 13
38. S.A. Wrighton, P. Maurel, E.G. Schuetz, P.B. Watkins, B. Young, and P.S. Guzelian Identification of the cytochrome P-450 induced by macrolide antibiotics in rat livers as the glucocorticoid responsive cytochrome P450p Biochemistry 24 1985 2171 2178