Association of polymorphisms in CYP17A1, MTP, and VLDLR with bone mineral density in community-dwelling Japanese women and men

Genomics

Volumn 86, Issue 1, 2005, Pages 76-85

  Yamada, Yoshiji ^a   Ando, Fujiko ^b   Shimokata, Hiroshi ^b  

^a MIE UNIVERSITY   (Japan)

^b NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

Author keywords

Bone density; Genetics; Microsomal triglyceride transfer protein; Osteoporosis; Polymorphism, genetic; Steroid 17 hydroxylase; VLDL receptor

Indexed keywords

CYTOCHROME P450 17; CYTOCHROME P450 17A1; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN RECEPTOR;

ADULT; ALLELE; ARTICLE; BONE DENSITY; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; JAPAN; MALE; NORMAL HUMAN; POSTMENOPAUSE; PRIORITY JOURNAL;

ASIAN CONTINENTAL ANCESTRY GROUP; BONE DENSITY; CARRIER PROTEINS; CHI-SQUARE DISTRIBUTION; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; LIPIDS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, LDL; RESIDENCE CHARACTERISTICS; STEROID 17-ALPHA-HYDROXYLASE; TRINUCLEOTIDE REPEATS;

EID: 20444423769     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ygeno.2005.03.005     Document Type: Article

References (50)

1. J.A. Kanis, L.J. Melton III, C. Christiansen, C.C. Johnston, and N. Khaltaev The diagnosis of osteoporosis J. Bone Miner. Res. 9 1994 1137 1141
2. N.A. Pocock Genetic determinations of bone mass in adults: a twin study J. Clin. Invest. 80 1987 706 710
3. R. Gueguen Segregation analysis and variance components analysis of bone mineral density in healthy families J. Bone Miner. Res. 10 1995 2017 2022
4. G.M. Howard, T.V. Nguyen, M. Harris, P.J. Kelly, and J.A. Eisman Genetic and environmental contributions to the association between quantitative ultrasound and bone mineral density measurements: a twin study J. Bone Miner. Res. 13 1998 1318 1327
5. M.L. Johnson Linkage of a gene causing high bone mass to human chromosome 11 (11q12-13) Am. J. Hum. Genet. 60 1997 1326 1332
6. M.J. Econs Confirmation of linkage to chromosome 1q for peak vertebral bone mineral density in premenopausal white women Am. J. Hum. Genet. 74 2004 223 228
7. N.A. Morrison Prediction of bone density from vitamin D receptor alleles Nature 367 1994 284 287
8. A.G. Uitterlinden Relation of alleles of the collagen type Iα1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women N. Engl. J. Med. 338 1998 1016 1021
9. Y. Yamada, F. Ando, N. Niino, and H. Shimokata Transforming growth factor-β1 gene polymorphism and bone mineral density JAMA 285 2001 167 168
10. J.P. Ioannidis Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes JAMA 292 2004 2105 2114
11. R.J. Auchus, and W.L. Miller Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations Mol. Endocrinol. 13 1999 1169 1182
12. T. Yanase, E.R. Simpson, and M.R. Waterman 17 Alpha-hydroxylase/17,20- lyase deficiency: from clinical investigation to molecular definition Endocr. Rev. 12 1991 91 108
13. A.H. Carey Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17 Hum. Mol. Genet. 3 1994 1873 1876
14. V.N. Kristensen CYP17 and breast cancer risk: the polymorphism in the 5′ flanking area of the gene does not influence binding to Sp-1 Cancer Res. 59 1999 2825 2828
15. C.J. Lin, J.W. Martens, and W.L. Miller NF-1C, Sp1, and Sp3 are essential for transcription of the human gene for P450c17 (steroid 17alpha-hydroxylase/ 17,20 lyase) in human adrenal NCI-H295A cells Mol. Endocrinol. 15 2001 1277 1293
16. J.M. Zmuda, J.A. Cauley, L.H. Kuller, and R.E. Ferrell A common promoter variant in the cytochrome P450c17alpha (CYP17) gene is associated with bioavailability of testosterone levels and bone size in men J. Bone Miner. Res. 16 2001 911 917
17. J. Somner Polymorphisms in the P450 c17 (17-hydroxylase/17,20-lyase) and P450 c19 (aromatase) genes: association with serum sex steroid concentrations and bone mineral density in postmenopausal women J. Clin. Endocrinol. Metab. 89 2004 344 351
18. C.L. Tofteng Two single nucleotide polymorphisms in the CYP17 and COMT genes-relation to bone mass and longitudinal bone changes in postmenopausal women with or without hormone replacement therapy. The Danish Osteoporosis Prevention Study Calcif. Tissue Int. 75 2004 123 132
19. R.J. Bergman Age-related changes in osteogenic stem cells in mice J. Bone Miner. Res. 11 1996 568 577
20. F. Parhami Atherogenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells J. Bone Miner. Res. 14 1999 2067 2078
21. D.D. Diascro Jr. High fatty acid content in rabbit serum is responsible for the differentiation of osteoblasts into adipocyte-like cells J. Bone Miner. Res. 13 1998 96 106
22. S.I. McFarlane, R. Muniyappa, R. Francisco, and J.R. Sowers Pleiotropic effects of statins: lipid reduction and beyond J. Clin. Endocrinol. Metab. 87 2002 1451 1458
23. P. Orozco Atherogenic lipid profile and elevated lipoprotein (a) are associated with lower bone mineral density in early postmenopausal overweight women Eur. J. Epidemiol. 19 2004 1105 1112
24. A. Poli Plasma low-density lipoprotein cholesterol and bone mass densitometry in postmenopausal women Obstet. Gynecol. 102 2003 922 926
25. D.A. Gordon, J.R. Wetterau, and R.E. Gregg Microsomal triglyceride transfer protein: a protein complex required for the assembly of lipoprotein particles Trends Cell Biol. 5 1995 317 321
26. D. Sharp Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia Nature 365 1993 65 69
27. H. Ledmyr Variants of the microsomal triglyceride transfer protein gene are associated with plasma cholesterol levels and body mass index J. Lipid Res. 43 2002 51 58
28. F. Karpe, B. Lundahl, E. Ehrenborg, P. Eriksson, and A. Hamsten A common functional polymorphism in the promoter region of the microsomal triglyceride transfer protein gene influences plasma LDL levels Arterioscler. Thromb. Vasc. Biol. 18 1998 756 761
29. H. Ledmyr The microsomal triglyceride transfer protein gene -493 T variant lowers cholesterol but increases the risk of coronary heart disease Circulation 109 2004 2279 2284
30. B.J. Geesaman Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan Proc. Natl. Acad. Sci. USA 100 2003 14115 14120
31. S. Takahashi, Y. Kawarabayasi, T. Nakai, J. Sakai, and T. Yamamoto Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity Proc. Natl. Acad. Sci. USA 89 1992 9252 9256
32. J. Sakai Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene J. Biol. Chem. 269 1994 2173 2182
33. N. Helbecque The role of a triplet repeat sequence of the very low density lipoprotein receptor gene in plasma lipid and lipoprotein level variability in humans Arterioscler. Thromb. Vasc. Biol. 17 1997 2759 2764
34. K. Okuizumi Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease Nat. Genet. 11 1995 207 209
35. H.S. Feigelson, G.A. Coetzee, L.N. Kolonel, R.K. Ross, and B.E. Henderson A polymorphism in the CYP17 gene increases the risk of breast cancer Cancer Res. 57 1997 1063 1065
36. A.B. Spurdle CYP17 promoter polymorphism and breast cancer in Australian women under age forty years J. Natl. Cancer Inst. 92 2000 1674 1681
37. H.S. Feigelson Cytochrome P450c17alpha gene (CYP17) polymorphism is associated with serum estrogen and progesterone concentrations Cancer Res. 58 1998 585 587
38. C.A. Haiman The relationship between a polymorphism in CYP17 with plasma hormone levels and breast cancer Cancer Res. 59 1999 1015 1020
39. H.S. Feigelson Cytochrome P450c17alpha gene (CYP17) polymorphism predicts use of hormone replacement therapy Cancer Res. 59 1999 3908 3910
40. B.L. Riggs, S. Khosla, and L.J. Melton III Sex steroids and the construction and conservation of the adult skeleton Endocr. Rev. 23 2002 279 302
41. P. Couture Absence of association between genetic variation in the promoter of the microsomal triglyceride transfer protein gene and plasma lipoproteins in the Framingham Offspring Study Atherosclerosis 148 2000 337 343
42. S.H. Juo, Z. Han, J.D. Smith, L. Colangelo, and K. Liu Common polymorphism in promoter of microsomal triglyceride transfer protein gene influences cholesterol, apoB, and triglyceride levels in young African American men: results from the Coronary Artery Risk Development in Young Adults (CARDIA) study Arterioscler. Thromb. Vasc. Biol. 20 2000 1316 1322
43. J. St-Pierre Visceral obesity and hyperinsulinemia modulate the impact of the microsomal triglyceride transfer protein -493G/T polymorphism on plasma lipoprotein levels in men Atherosclerosis 160 2002 317 324
44. S. Takahashi The very low-density lipoprotein (VLDL) receptor: characterization and function as a peripheral lipoprotein receptor J. Atheroscler. Thromb. 11 2004 200 208
45. P.K. Frykman, M.S. Brown, T. Yamamoto, J.L. Goldstein, and J. Herz Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor Proc. Natl. Acad. Sci. USA 92 1995 8453 8457
46. N. Helbecque VLDL receptor polymorphism, cognitive impairment, and dementia Neurology 56 2001 1183 1188
47. H. Shimokata, F. Ando, and N. Niino A new comprehensive study on aging-the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA) J. Epidemiol. 10 2000 S1 S9
48. Y. Yamada, F. Ando, N. Niino, and H. Shimokata Association of polymorphisms of interleukin-6, osteocalcin, and vitamin D receptor genes, alone or in combination, with bone mineral density in community-dwelling Japanese women and men J. Clin. Endocrinol. Metab. 88 2003 3372 3378
49. Y. Yamada, F. Ando, N. Niino, and H. Shimokata Association of polymorphisms of androgen receptor and klotho genes with bone mineral density in Japanese women J. Mol. Med. 83 2005 50 57
50. Y. Yamada Prediction of the risk of myocardial infarction from polymorphisms in candidate genes N. Engl. J. Med. 347 2002 1916 1923