Isogenic human cell lines for drug discovery: Regulation of target gene expression by engineered zinc-finger protein transcription factors

Journal of Biomolecular Screening

Volumn 10, Issue 4, 2005, Pages 304-313

  Liu, Pei Qi ^a   Tan, Siyuan ^a   Mendel, Matthew C ^a   Murrills, Richard J ^b   Bhat, Bheem M ^b   Schlag, Brian ^b   Samuel, Rachelle ^b   Matteo, Jeanne J ^b   De La Rosa, Ragan ^a   Howes, Katherine ^a   Reik, Andreas ^a   Case, Casey C ^a   Bex, Frederick J ^b   Young, Kathleen ^b   Gregory, Philip D ^a  

^a SANGAMO BIOSCIENCES INC   (United States)

^b PFIZER INC   (United States)

Author keywords

G protein coupled receptors; High throughput screening; Isogenic cell lines; Zinc finger protein

Indexed keywords

CYCLIC AMP; LIGAND; PARATHYROID HORMONE RECEPTOR 1; ZINC FINGER PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CELL LINE; CONTROLLED STUDY; GENE EXPRESSION; GENE IDENTIFICATION; GENE TARGETING; GENETIC ENGINEERING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMINO ACID SEQUENCE; BASE SEQUENCE; CELL LINE; DNA PRIMERS; GENE EXPRESSION REGULATION; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN ENGINEERING; RECEPTOR, PARATHYROID HORMONE, TYPE 1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION FACTORS; ZINC FINGERS;

EID: 20444423632     PISSN: 10870571     EISSN: None     Source Type: Journal    
DOI: 10.1177/1087057104272663     Document Type: Article

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