Dysfunction of soluble guanylyl cyclase in aorta and kidney of Goto-Kakizaki rats: Influence of age and diabetic state

Nitric Oxide - Biology and Chemistry

Volumn 6, Issue 1, 2002, Pages 85-95

  Witte, Klaus ^a   Jacke, Kerstin ^a   Stahrenberg, Raoul ^a   Arlt, Gerrit ^a   Reitenbach, Ina ^a   Schilling, Lothar ^a   Lemmer, Björn ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Guanylyl cyclase; Insulin; Radiotelemetry; Signal transduction; Type 2 diabetes mellitus

Indexed keywords

GUANYLATE CYCLASE; NITRIC OXIDE DONOR; PROTEIN SUBUNIT;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; BLOOD PRESSURE MONITORING; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; ENZYME DEFECT; KIDNEY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; TELEMETRY; ANIMAL; BLOOD PRESSURE; DRUG EFFECT; ENZYMOLOGY; HEART RATE; HYPERTENSION; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; PHYSIOLOGY; SOLUBILITY; VASODILATATION; WISTAR RAT;

ANIMALIA; RATTUS NORVEGICUS;

AGE FACTORS; ANIMALS; AORTA; BLOOD PRESSURE; DIABETES MELLITUS, TYPE 2; GUANYLATE CYCLASE; HEART RATE; HYPERTENSION; KIDNEY; MALE; NITRIC OXIDE DONORS; PROTEIN SUBUNITS; RATS; RATS, INBRED STRAINS; RATS, WISTAR; SOLUBILITY; VASODILATION;

EID: 0036324622     PISSN: 10898603     EISSN: None     Source Type: Journal    
DOI: 10.1006/niox.2001.0363     Document Type: Article

References (28)

1. Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus
2. Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus
3. Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus
4. Impaired endothelium-dependent and independent dilation of forearm resistance arteries in men with diet-treated non-insulin-dependent diabetes: Role of dyslipidaemia
5. Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus
6. A new form of guanylyl cyclase is preferentially expressed in rat kidney
7. The spontaneous-diabetes rat: A model of noninsulin dependent diabetes mellitus
8. Beta-cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetes
9. Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat
10. Changes in islet blood flow in rats with NIDDM
11. Insulin-induced activation of glycerol-3-phosphate acyltransferase by a chiro-inositol-containing insulin mediator is defective in adipocytes of insulin-resistant, type II diabetic, Goto-Kakizaki rats
12. Insulin resistance in the GK rat: Decreased receptor number but normal kinase activity in liver
13. Rhéologie érythrocytaire et hypertrophie cardiaque au cours du diabète sucré
14. Insulin resistance and body fat distribution
15. Rodent models of nephropathy associated with type II diabetes
16. Contribution of the nitric oxide-guanylyl cyclase system to circadian regulation of blood pressure in normotensive Wistar-Kyoto rats
17. Activation of purified guanylate cyclase by arachidonic acid requires absence of enzyme-bound heme
18. Circadian blood pressure variation in transgenic hypertensive rats
19. Pharmfit - A nonlinear fitting program for pharmacology
20. Endothelial dysfunction in diabetes
21. Nitric oxide may be required to prevent hypertension at the onset of diabetes
22. 1 subunit yields a nitric oxide-insensitive form of soluble guanylyl cyclase
23. Functions of conserved cysteines of soluble guanylyl cyclase
24. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
25. Contribution of the renin-angiotensin system to subsensitivity of soluble guanylyl cyclase in TGR(mREN2)27 rats
26. The β2 subunit inhibits stimulation of the α1/β1 form of soluble guanylyl cyclase by nitric oxide
27. Association of prolonged hyperglycemia with glomerular hypertrophy and renal basement membrane thickening in the Goto Kakizaki model of non-insulin-dependent diabetes mellitus