Modulation of phosphatidylinositol 3-kinase signaling reduces intimal hyperplasia in aortocoronary saphenous vein grafts

Journal of Thoracic and Cardiovascular Surgery

Volumn 129, Issue 6, 2005, Pages 1405-1413

  Hata, Jonathan A ^a   Petrofski, Jason A ^a   Schroder, Jacob N ^a   Williams, Matthew L ^a,b   Timberlake, Sarah H ^a   Pippen, Anne ^a   Corwin, Michael T ^a   Solan, Amy K ^a   Jakoi, Andre ^a   Gehrig, Thomas R ^a   Kontos, Christopher D ^a   Milano, Carmelo A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; PHOSPHATE BUFFERED SALINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOGRAPHY; ARTERY INTIMA PROLIFERATION; ARTICLE; CELL ISOLATION; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DOG; EMBRYO; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC CODE; GRAFT PATENCY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LEFT ANTERIOR DESCENDING CORONARY ARTERY; NONHUMAN; POLYMERASE CHAIN REACTION; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; SAPHENOUS VEIN GRAFT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TRANSGENE; VASCULAR SMOOTH MUSCLE; VIRAL GENE DELIVERY SYSTEM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL DIVISION; CORONARY ARTERY BYPASS; DOGS; GRAFT OCCLUSION, VASCULAR; HYPERPLASIA; MUSCLE, SMOOTH, VASCULAR; SAPHENOUS VEIN; SIGNAL TRANSDUCTION; TUNICA INTIMA;

EID: 20444391695     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2004.11.048     Document Type: Article

References (30)

1. L. Campeau, M. Enjalbert, J. Lesperance, C. Vaislic, C.M. Grondin, M.G. Bourassa Atherosclerosis and late closure of aortocoronary saphenous vein grafts sequential angiographic studies at 2 weeks, 1 year, 5 to 7 years, and 10 to 12 years after surgery Circulation 68 suppl II 1983 II1 II7
2. D.S. Souza, M.R. Dashwood, J.C. Tsui Improved patency in vein grafts harvested with surrounding tissue results of a randomized study using three harvesting techniques Ann Thorac Surg 73 2002 1189 1195
3. S. Goldman, J. Copeland, T. Moritz Improvement in early saphenous vein graft patency after coronary artery bypass surgery with antiplatelet therapy results of a Veterans Administration Cooperative Study Circulation 77 1988 1324 1332
4. G.H. Gibbons, V.J. Dzau The emerging concept of vascular remodeling N Engl J Med 330 1994 1431 1438
5. R.C. Braun-Dullaeus, M.J. Mann, V.J. Dzau Cell cycle progression new therapeutic target for vascular proliferative disease Circulation 98 1998 82 89
6. L.E. Rameh, L.C. Cantley The role of phosphoinositide 3-kinase lipid products in cell function J Biol Chem 274 1999 8347 8350
7. J.E. Sousa, M.A. Costa, A.C. Abizaid Sustained suppression of neointimal proliferation by sirolimus-eluting stents one-year angiographic and intravascular ultrasound follow-up Circulation 104 2001 2007 2011
8. J. Downward Mechanisms and consequences of activation of protein kinase B/Akt Curr Opin Cell Biol 10 1998 262 267
9. J. Huang, C.D. Kontos Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN Arterioscler Thromb Vasc Biol 22 2002 745 751
10. J. Huang, C.D. Kontos PTEN modulates vascular endothelial growth factor mediated signaling and angiogenic effects J Biol Chem 277 2002 10760 10766
11. J.A. Petrofski, J.A. Hata, T.R. Gehrig Gene delivery to aortocoronary saphenous vein grafts in a large animal model of intimal hyperplasia J Thorac Cardiovasc Surg 127 2004 27 33
12. A.S. Shah, D.C. White, O. Tai Adenovirus-mediated genetic manipulation of the myocardial β-adrenergic signaling system in transplanted hearts J Thorac Cardiovasc Surg 123 2000 581 588
13. J. Gao, L. Niklason, R. Langer Surface hydrolysis of poly(glycolic acid) meshes increases the seeding density of vascular smooth muscle cells J Biomed Mater Res 42 1998 417 424
14. G. Thomas, M.N. Hall TOR signaling and control of cell growth Curr Opin Cell Biol 9 1997 782 787
15. E.F. Akowuah, P.J. Sheridan, G.J. Cooper, C. Newman Preventing saphenous vein graft failure does gene therapy have a role? Ann Thorac Surg 76 2003 L959 L966
16. W.R. Brody, W.W. Angell, J.C. Kosek Histologic fate of the venous coronary artery bypass in dogs Am J Pathol 66 1972 111 130
17. W.R. Brody, J.C. Kosek, W.W. Angell Changes in vein grafts following aorto-coronary bypass induced by pressure and ischemia J Thorac Cardiovasc Surg 66 1972 847 853
18. M.D. Silver, G.J. Wilson, W. Lixfield, A.S. Trimble, D.C. MacGregor Aortocoronary bypass graft in dogs late histological changes Pathology 8 1976 343 351
19. C.K. Chiu-Pinheiro, T. O'Brien, Z.S. Katusic, L.F. Bonilla, C.E. Hammer, H. Schaff Gene transfer to coronary artery bypass conduits Ann Thorac Surg 74 2002 1161 1166
20. D.G. Cable, J.A. Caccitolo, N. Caplice The role of gene therapy for intimal hyperplasia of bypass grafts Circulation 100 suppl II 1999 II392 II396
21. S.J. George, A.H. Boker, G.D. Angelini Gene transfer of tissue inhibitor of metalloproteinase-2 inhibits metalloproteinase activity and neointima formation in human saphenous veins Gene Ther 5 1998 1552 1560
22. T. ShiNtani, T. Takahasi, T. Takahashi Intraoperative transfection of vein grafts with the NFκB decoy in a canine aortocoronary bypass model a strategy to attenuate intimal hyperplasia Ann Thorac Surg 74 2002 1123 1137
23. M.K. Mann, A.D. Whittemore, M.C. Donaldson Ex-vivo gene therapy of human vascular bypass grafts with E2F decoy the PREVENT single-centre, randomised, controlled trial Lancet 354 1999 1493 1498
24. L.N. Walker, D.F. Bowen-Pope, R. Ross, M.A. Reidy Production of platelet-derived growth factor-like molecules by cultured arterial smooth muscle cells accompanies proliferation after arterial injury Proc Natl Acad Sci U S A 83 1986 7311 7315
25. E.G. Nabel, Z. Yang, S. Liptay Recombinant platelet-derived growth factor B gene expression in porcine arteries induce intimal hyperplasia in vivo J Clin Invest 91 1993 1822 1829
26. C.H. Heldin, B. Westermark Mechanism and in vivo role of platelet-derived growth factor Physiol Rev 79 1999 1283 1316
27. N. Pullen, G. Thomas The modular phosphorylation and activation of p70s6k FEBS Lett 410 1997 78 82
28. L. Xue, J.H. Murray, A.M. Tolkovsky The Ras/phosphatidylinositol 3-kinase, and Ras/ERK pathways that function as independent survival modules each of which inhibits a distinct apoptotic signaling pathway in sympathetic neurons J Biol Chem 275 2000 8817 8824
29. K.T. Nguyen, W.J. Wang, J.L. Chan, L.H. Wang Differential requirements of the MAP kinase and PI3 kinase signaling pathways in SRC- versus insulin and IGF-1 receptors-induced growth and transformation of rat intestinal epithelial cells Oncogene 19 2000 5385 5397
30. J. Huang, X.-L. Niu, A.M. Pippen, B.H. Annex, C.D. Kontos Adenovirus-mediated intraarterial delivery of PTEN inhibits neointimal hyperplasia Arterioscler Thromb Vasc Biol 25 2005 354 358