Sugar triggers our reward system. Sucrose releases opioids so that a triggering of sucrose consumption occurs - Insulin can block the opioid response;Socker triggar våra belöningssystem: Sött frisätter opiater som sätter fart på sötsuget - Insulin kan dämpa det

Lakartidningen

Volumn 102, Issue 21, 2005, Pages 1620-1627

  Erlanson Albertsson, Charlotte ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; OPIATE; OPIATE PEPTIDE; OPIATE RECEPTOR; SUCROSE; SUGAR;

ALCOHOLISM; ANIMAL; ANXIETY; APPETITE; BEVERAGE; BRAIN MAPPING; COLA; DIET RESTRICTION; DRUG EFFECT; FEEDING BEHAVIOR; FOOD INTAKE; HUMAN; INSULIN SENSITIVITY; NONHUMAN; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; RAT; REVIEW; REWARD; RISK FACTOR; SCIENTIFIC LITERATURE; STATISTICAL SIGNIFICANCE; SUGAR INTAKE; SWEDEN; SYMPTOM; TASTE; WITHDRAWAL SYNDROME;

ANIMALS; APPETITE; BEVERAGES; BRAIN MAPPING; CANDY; DIETARY SUCROSE; FOOD HABITS; HUMANS; INSULIN; OPIOID PEPTIDES; RATS; RECEPTORS, OPIOID; REWARD; RISK FACTORS; SUBSTANCE WITHDRAWAL SYNDROME; TASTE;

EID: 20444369530     PISSN: 00237205     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (20)

1. Colantuoni C, Rada P, McCarthy J, Patten C, Avena NM, Chadeayne A, et al. Evidence that intermittent, excessive sugar intake causes endogenous opioid dependence. Obes Res 2002;10:478-88.
2. Woods SC, Schwartz MW, Baskin DG, Seeley RJ. Food intake and the regulation of body weight. Annu Rev Psychol 2000;51:255-77.
3. Erlanson-Albertsson C. Regulation of macronutrient intake - carbohydrate, fat and protein. Nutr Neurosci 2000;3:215-29.
4. Zhang M, Kelley AE. Opiate agonists microinjected into the nucleus accumbens enhance sucrose drinking in rats. Psychopharmacology (Berl) 1997;132:350-60.
5. Kelley AE, Bakshi VP, Haber SN, Steininger TL, Will MJ, Zhang M. Opioid modulation of taste hedonics within the ventral striatum. Physiol Behav 2002;76:365-77.
6. Del Parigi A, Chen K, Salbe AD, Reiman EM, Tataranni PA. Are we addicted to food? Obes Res 2003;11:493-5.
7. Kelley AE, Bless EP, Swanson CJ. Investigation of the effects of opiate antagonists infused into the nucleus accumbens on feeding and sucrose drinking in rats. J Pharmacol Exp Ther 1996;278:1499-507.
8. Welch CC, Kim EM, Grace MK, Billington CJ, Levine AS. Palatability-induced hyperphagia increases hypothalamic Dynorphin peptide and mRNA levels. Brain Res 1996;721:126-31.
9. Ren K, Blass EM, Zhou Q, Dubner R. Suckling and sucrose ingestion suppress persistent hyperalgesia and spinal Fos expression after forepaw inflammation in infant rats. Proc Natl Acad Sci U S A 1997;94:1471-5.
10. Pomonis JD, Jewett DC, Kotz CM, Briggs JE, Billington CJ, Levine AS. Sucrose consumption increases naloxone-induced c-Fos immunoreactivity in limbic forebrain. Am J Physiol Regul Integr Comp Physiol 2000;278:R712-9.
11. King NA, Appleton K, Rogers PJ, Blundell JE. Effects of sweetness and energy in drinks on food intake following exercise. Physiol Behav 1999;66:375-9.
12. Raben A, Vasilaras TH, Moller AC, Astrup A. Sucrose compared with artificial sweeteners: different effects on ad libitum food intake and body weight after 10 wk of supplementation in overweight subjects. Am J Clin Nutr 2002;76:721-9.
13. Barr RG, Pantel MS, Young SN, Wright JH, Hendricks LA, Gravel R. The response of crying newborns to sucrose: is it a »sweetness« effect? Physiol Behav 1999;66:409-17.
14. Yeomans MR, Gray RW. Opioid peptides and the control of human ingestive behaviour. Neurosci Biobehav Rev 2002;26:713-28.
15. Levine AS, Kotz CM, Gosnell BA. Sugars: hedonic aspects, neuroregulation, and energy balance. Am J Clin Nutr 2003;78:834S-42S.
16. Jonsson B, Nordström P. Sockerbomben - bli fri från ditt sockerberoende. Stockholm: Forum; 2004.
17. Kranzler HR, Sandstrom KA, Van Kirk J. Sweet taste preference as a risk factor for alcohol dependence. Am J Psychiatry 2001;158:813-5.
18. Sipols AJ, Bayer J, Bennett R, Figlewicz DP. Intraventricular insulin decreases kappa opioid-mediated sucrose intake in rats. Peptides 2002;23:2181-7.
19. Popkin BM, Nielsen SJ. The sweetening of the world's diet. Obes Res 2003;11:1325-32.
20. Elliott SS, Keim NL, Stern JS, Teff K, Havel PJ. Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 2002;76:911-22.