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0004241663
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Stressgen moves new treatment for cervical cancer into development
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271440 Stressgen Biotechnology Corp. PRESS RELEASE December 08
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271440 Stressgen moves new treatment for cervical cancer into development. Stressgen Biotechnology Corp PRESS RELEASE 1997 December 08
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(1997)
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20344379282
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Stressgen reports second quarter results
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296620 Stressgen Biotechnology Corp. PRESS RELEASE September 01
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296620 Stressgen reports second quarter results. Stressgen Biotechnology Corp PRESS RELEASE 1998 September 01
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(1998)
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20344378549
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Streasgen initiates phase I clinical trial of HspE7 for cervical dysplasia
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313229 StressGen Biotechnologies Corp. PRESS RELEASE February 02
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313229 Streasgen initiates phase I clinical trial of HspE7 for cervical dysplasia. StressGen Biotechnologies Corp PRESS RELEASE 1999 February 02
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(1999)
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Stressgen initiates phase II clinical trial of its lead compound HspE7; efficacy of HspE7 in high-grade anal dysplasia to be tested
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344720 StressGen Biotechnologies Corp. PRESS RELEASE October 25
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344720 Stressgen initiates phase II clinical trial of its lead compound HspE7; efficacy of HspE7 in high-grade anal dysplasia to be tested. StressGen Biotechnologies Corp PRESS RELEASE 1999 October 25
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(1999)
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20344395960
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Stressgen Biotechnologies announces initiation of phase II study with HspE7
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360050 Stressgen Biotechnologies Corp. PRESS RELEASE March 16
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360050 Stressgen Biotechnologies announces initiation of phase II study with HspE7. Stressgen Biotechnologies Corp PRESS RELEASE 2000 March 16
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(2000)
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20344380017
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Stressgen reports fusion protein drug for human papillomavirus demonstrated positive immune responses and is well tolerated in phase I study - Data presented at Annual Meeting of American Society of Clinical Oncology
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367767 Stressgen Biotechnologies Corp. PRESS RELEASE May 22
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367767 Stressgen reports fusion protein drug for human papillomavirus demonstrated positive immune responses and is well tolerated in phase I study - data presented at Annual Meeting of American Society of Clinical Oncology. Stressgen Biotechnotogles Corp PRESS RELEASE 2000 May 22
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(2000)
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0004236614
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Antigen specific cell mediated immunity in phase I dose escalation trial of single doses of HspE-7 in healthy volunteers
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368843 Abs
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368843 Antigen specific cell mediated immunity in phase I dose escalation trial of single doses of HspE-7 in healthy volunteers. Kadish AS, Wang Y, Ho G, He W, Chu NR, Winnet M, Talluri K, Mizzen L, Siegel I, Neefe JR PROC AM SOC CLIN ONCOL 2000 19 Abs 1789
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(2000)
Proc. Am. Soc. Clin. Oncol.
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, pp. 1789
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Kadish, A.S.1
Wang, Y.2
Ho, G.3
He, W.4
Chu, N.R.5
Winnet, M.6
Talluri, K.7
Mizzen, L.8
Siegel, I.9
Neefe, J.R.10
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8
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20344406904
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Stressgen presents positive clinical data at 18th International Papillomavirus Conference: HspE7: A novel heat shock protein fusion for HPV-related diseases
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376324 Stressgen Biotechnologies Corp. PRESS RELEASE July 26
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376324 Stressgen presents positive clinical data at 18th International Papillomavirus Conference: HspE7: A novel heat shock protein fusion for HPV-related diseases. Stressgen Biotechnologies Corp PRESS RELEASE 2000 July 26
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(2000)
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Stressgen Biotechnologles initiates HspE7 phase II trial in cervical cancer
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381859 Stressgen Biotechnologies Corp. PRESS RELEASE September 06
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381859 Stressgen Biotechnologles initiates HspE7 phase II trial in cervical cancer. Stressgen Biotechnologies Corp PRESS RELEASE 2000 September 06
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(2000)
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0004172977
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Stressgen initiates HspE7 phase III trial in HPV-related anal dysplasia; CDC reports HPV second only to HIV in US STD related healthcare costs
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388696 Stressgen Biotechnologies Corp. PRESS RELEASE November 06
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388696 Stressgen initiates HspE7 phase III trial in HPV-related anal dysplasia; CDC reports HPV second only to HIV in US STD related healthcare costs. Stressgen Biotechnologies Corp PRESS RELEASE 2000 November 06
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(2000)
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20344386324
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Stressgen reports third quarter financial results: Underwriters exercise their over-allotment option
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389732 Stressgen Biotechnologies Corp. PRESS RELEASE November 14
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389732 Stressgen reports third quarter financial results: Underwriters exercise their over-allotment option. Stressgen Biotechnologies Corp PRESS RELEASE 2000 November 14
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(2000)
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20344391230
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Stressgen initiates phase II genital warts trial - Trial expands broad-spectrum activity of HspE7 in HPV-related diseases
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395633 Stressgen Biotechnology Corp. PRESS RELEASE January 09
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395633 Stressgen initiates phase II genital warts trial - trial expands broad-spectrum activity of HspE7 in HPV-related diseases. Stressgen Biotechnology Corp PRESS RELEASE 2001 January 09
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(2001)
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Stressgen Biotechnologies announces 2000 financial results: Company demonstrated proof of principle with heat shock fusion technology and advanced lead product to phase III clinical trials
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401365 PRESS RELEASE March 08
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401365 Stressgen Biotechnologies announces 2000 financial results: Company demonstrated proof of principle with heat shock fusion technology and advanced lead product to phase III clinical trials. PRESS RELEASE 2001 March 08
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(2001)
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14
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0033838826
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Immunotherapy of a human papillomavirus (HPV) type 16 E7-expressing tumour by administration of fusion protein comprising Mycobacterium bovis bacille Calmette-Guérin (BCG) Hsp65 and HPV16 E7
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403082
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403082 Immunotherapy of a human papillomavirus (HPV) type 16 E7-expressing tumour by administration of fusion protein comprising Mycobacterium bovis bacille Calmette-Guérin (BCG) Hsp65 and HPV16 E7. Chu NR, Wu HB, Wu T, Boux LJ, Siegel MI, Mizzen LA CLIN EXP IMMUNOL 2000 121 2 216-225
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(2000)
Clin. Exp. Immunol.
, vol.121
, Issue.2
, pp. 216-225
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Chu, N.R.1
Wu, H.B.2
Wu, T.3
Boux, L.J.4
Siegel, M.I.5
Mizzen, L.A.6
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15
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20344365428
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Stressgen's HspE7 receives orphan drug status for recurrent respiratory papillomatosis
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403517 Stressgen Biotechnology Corp. Press Release March 29
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403517 Stressgen's HspE7 receives orphan drug status for recurrent respiratory papillomatosis. Stressgen Biotechnology Corp Press Release 2001 March 29
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(2001)
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20344365176
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Stressgen's genital warts program ahead of schedule due to early completion of patient enrollment in phase II trial: First genital warts data to be presented in June 2001
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405228 Stressgen Biotechnologies Corp. PRESS RELEASE April 10
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405228 Stressgen's genital warts program ahead of schedule due to early completion of patient enrollment in phase II trial: First genital warts data to be presented in June 2001. Stressgen Biotechnologies Corp PRESS RELEASE 2001 April 10
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(2001)
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Stressgen presents now data indicating the majority of anal dysplasia patients improve with HspE7: Data confirm earlier findings: 73% of patients downgrade from high grade to low grade dysplasia
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406969 StressGen Biotechnologies Corp. PRESS RELEASE April 24
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406969 Stressgen presents now data indicating the majority of anal dysplasia patients improve with HspE7: Data confirm earlier findings: 73% of patients downgrade from high grade to low grade dysplasia. StressGen Biotechnologies Corp PRESS RELEASE 2001 April 24
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(2001)
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In vivo cytotoxic T-lymphocyte elicitation by mycobacterial heat shock protein 70 fusion proteins maps to a discrete domain and is CD4+ T-cell independent
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407840
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407840 In vivo cytotoxic T-lymphocyte elicitation by mycobacterial heat shock protein 70 fusion proteins maps to a discrete domain and is CD4+ T-cell independent. Huang Q, Richmond JF, Suzue K, Eisen HN, Young RA J EXP MED 2000 191 2 403-408
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J. Exp. Med.
, vol.191
, Issue.2
, pp. 403-408
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Huang, Q.1
Richmond, J.F.2
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Young, R.A.5
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19
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20344399496
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Hsp fusion technology- status of product development
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408192 May 04 Company World Wide Web Site
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408192 Hsp fusion technology- status of product development. Company World Wide Web site 2001 May 04
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Preliminary clinical data demonstrate robust activity for HspE7 in genital warts
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411993 Stressgen Biotechnologies Corp. PRESS RELEASE June 06
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411993 Preliminary clinical data demonstrate robust activity for HspE7 in genital warts. Stressgen Biotechnologies Corp PRESS RELEASE 2001 June 06
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Stressgen completes early enrollment in its phase III trial for HspE7 for anal dysplasia caused by HPV
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417630 Stressgen Biotechnologies Corp. PRESS RELEASE August 01
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417630 Stressgen completes early enrollment in its phase III trial for HspE7 for anal dysplasia caused by HPV. Stressgen Biotechnologies Corp PRESS RELEASE 2001 August 01
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HspE7 treatment of anal dysplasia: Results of an open label trial of HspE7 and comparison with a prior controlled trial of low dose HspE7
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421851 Abs
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421851 HspE7 treatment of anal dysplasia: Results of an open label trial of HspE7 and comparison with a prior controlled trial of low dose HspE7. Palefsky JM, Goldstone SE, Winnett M, Siegel MI, Neefe JR ICAAC 2001 41 Abs 1600
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(2001)
ICAAC
, vol.41
, pp. 1600
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Goldstone, S.E.2
Winnett, M.3
Siegel, M.I.4
Neefe, J.R.5
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23
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Stressgen initiates phase II recurrent respiratory papillomatosis trial in children
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429724 Stressgen Biotechnologies Corp. PRESS RELEASE November 19
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429724 Stressgen initiates phase II recurrent respiratory papillomatosis trial in children. Stressgen Biotechnologies Corp PRESS RELEASE 2001 November 19
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(2001)
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Stresagen announces robust HPV data from multiple phase II clinical trials
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431409 Stressgen Biotechnologies Corp. PRESS RELEASE November 29
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431409 Stresagen announces robust HPV data from multiple phase II clinical trials. Stressgen Biotechnologies Corp PRESS RELEASE 2001 November 29
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(2001)
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HspE7 potentially eliminates the need for surgical intervention and improves the quality of life in anal dysplasia patients 15-month data from ongoing registry indicate continued improvement to complete responses and durability
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434191 Stressgen Biotechnologies Corp. PRESS RELEASE December 18
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434191 HspE7 potentially eliminates the need for surgical intervention and improves the quality of life in anal dysplasia patients 15-month data from ongoing registry indicate continued improvement to complete responses and durability. Stressgen Biotechnologies Corp PRESS RELEASE 2001 December 18
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Stressgen announces issuance of US patent solidifying its heat shock protein-based technology platform
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434877 Stressgen Biotechnologies Corp. PRESS RELEASE January 04
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434877 Stressgen announces issuance of US patent solidifying its heat shock protein-based technology platform. Stressgen Biotechnologies Corp PRESS RELEASE 2002 January 04
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(2002)
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Stressgen's new European patent for heat shock protein fusions maximizes international marketing opportunities
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437198 Stressgen Biotechnologies Corp. PRESS RELEASE January 23
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437198 Stressgen's new European patent for heat shock protein fusions maximizes international marketing opportunities. Stressgen Blotechnologies Corp PRESS RELEASE 2002 January 23
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(2002)
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Company reveals new aspects of mechanism of action for HspE7 and confirms immunostimulatory capabilities of platform technology for hepatitis B virus
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450579 Stressgen Biotechnologies Corp. PRESS RELEASE May 07
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450579 Company reveals new aspects of mechanism of action for HspE7 and confirms immunostimulatory capabilities of platform technology for hepatitis B virus. Stressgen Biotechnologies Corp PRESS RELEASE 2002 May 07
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(2002)
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Stressgen Biotechnologies and Roche announce global development and marketing collaboration valued up to $204 million US
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455972 PRESS RELEASE June 24
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455972 Stressgen Biotechnologies and Roche announce global development and marketing collaboration valued up to $204 million US. PRESS RELEASE 2002 June 24
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(2002)
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Roche's presence in virology strengthened through drug development collaboration with Victoria-based Stressgen
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455974 Stressgen Biotechnology Corp. PRESS RELEASE June 24
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455974 Roche's presence in virology strengthened through drug development collaboration with Victoria-based Stressgen. Stressgen Biotechnology Corp PRESS RELEASE 2002 June 24
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(2002)
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Encapsulated plasmid DNA treatment for human papillomavirus 16-associated anal dysplasia: A phase I study of ZYC-101
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457276
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457276 Encapsulated plasmid DNA treatment for human papillomavirus 16-associated anal dysplasia: A phase I study of ZYC-101. Klencke B, Matijevic M, Urban RG, Lathey JL, Thatcher J, Weinberg V, Wilson J, Darragh T CLIN CANCER RES 2002 8 5 1028-1037
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, vol.8
, Issue.5
, pp. 1028-1037
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Thatcher, J.5
Weinberg, V.6
Wilson, J.7
Darragh, T.8
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32
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Stressgen announces presentation of data on the mechanism for the immunotherapeutic activity of HspE7 at HPV 2002
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466089 Stressgen Biotechnologies Corp. PRESS RELEASE October 07
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466089 Stressgen announces presentation of data on the mechanism for the immunotherapeutic activity of HspE7 at HPV 2002. Stressgen Biotechnologies Corp PRESS RELEASE 2002 October 07
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(2002)
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Stressgen announces presentation of new phase II HspE7 data on genital warts and anal dysplasia at HPV 2002
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466092 Stressgen Biotechnologies Corp. PRESS RELEASE October 07
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466092 Stressgen announces presentation of new phase II HspE7 data on genital warts and anal dysplasia at HPV 2002. Stressgen Biotechnologies Corp PRESS RELEASE 2002 October 07
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Stressgen announces the initiation of enrollment of patients for the first of multiple trials planned to evaluate HspE7 in HPV-related dysplasia and cancer
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476323 Stressgen Biotechnologies Corp. PRESS RELEASE January 15
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476323 Stressgen announces the initiation of enrollment of patients for the first of multiple trials planned to evaluate HspE7 in HPV-related dysplasia and cancer. Stressgen Biotechnologies Corp PRESS RELEASE 2003 January 15
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Stressgen granted European patent covering lead product HspE7 and other human papillomavirus therapeutics
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477989 StressGen Biotechnologies Corp. PRESS RELEASE February 04
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477989 Stressgen granted European patent covering lead product HspE7 and other human papillomavirus therapeutics. StressGen Biotechnologies Corp PRESS RELEASE 2003 February 04
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Stressgen granted US patent covering HspE7 and additional human papillomavirus therapeutic products
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480198 Stressgen Biotechnologies Corp. PRESS RELEASE February 27
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480198 Stressgen granted US patent covering HspE7 and additional human papillomavirus therapeutic products. Stressgen Biotechnologies Corp PRESS RELEASE 2003 February 27
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(2003)
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Stressgen receives Roche milestones totaling US$4.5 million
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487998 Stressgen Biotechnology Corp. PRESS RELEASE April 30
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487998 Stressgen receives Roche milestones totaling US$4.5 million. Stressgen Biotechnology Corp PRESS RELEASE 2003 April 30
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(2003)
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Tan, J.7
Perrin, L.8
O'Connor, V.9
Ng, P.10
White, O.11
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Stressgen announces statistically significant results with HspE7 to treat RRP
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492905 Stressgen Biotechnologies Corp. PRESS RELEASE June 10
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492905 Stressgen announces statistically significant results with HspE7 to treat RRP. Stressgen Biotechnologies Corp PRESS RELEASE 2003 June 10
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(2003)
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504507 Papillomavirus vaccines in clinical trials. Galloway D LANCET INFECT DIS 2003 3 8 469-475
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Stressgen presents results of pediatric phase II RRP trial at ICAAC supporting pivotal phase III trial
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505082 Stressgen Biotechnologies Corp. PRESS RELEASE September 16
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505082 Stressgen presents results of pediatric phase II RRP trial at ICAAC supporting pivotal phase III trial. Stressgen Biotechnologles Corp PRESS RELEASE 2003 September 16
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List of all orphan products designations and approval
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507427 Federal Drug Agency INTERNET SITE October 15
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507427 List of all orphan products designations and approval. Federal Drug Agency INTERNET SITE 2002 October 15 (http://www.fda.gov)
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(2002)
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54
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20344397782
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Stressgen presents longer-term phase II data on HSPE7 for RRP at pediatric conference
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511305 Stressgen Biotechnologies Corp. PRESS RELEASE November 03
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511305 Stressgen presents longer-term phase II data on HSPE7 for RRP at pediatric conference. Stressgen Biotechnologies Corp PRESS RELEASE 2003 November 03
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(2003)
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55
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20344400729
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Stressgen and Roche broaden heat shock protein agreement to maximize value of HspE7
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515802 PRESS RELEASE December 02
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515802 Stressgen and Roche broaden heat shock protein agreement to maximize value of HspE7. PRESS RELEASE 2003 December 02
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(2003)
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56
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20344399986
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Stressgen receives FDA fast track designation for HspE7
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516127 PRESS RELEASE December 04
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516127 Stressgen receives FDA fast track designation for HspE7. PRESS RELEASE 2003 December 04
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(2003)
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57
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17444402793
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Stressgen reports HspE7 results from two clinical trials
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524460 PRESS RELEASE February 24
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524460 Stressgen reports HspE7 results from two clinical trials. PRESS RELEASE 2004 February 24
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(2004)
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58
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20344403855
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Stressgen Biotechnologies: Form 10-K 2003
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525534 February 12
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525534 Stressgen Biotechnologies: Form 10-K 2003. FORM 10-K 2004 February 12
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(2004)
FORM 10-K
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59
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20344363992
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Stressgen granted additional patent covering use of lead compound, HspE7
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561598 Stressgen Biotechnologies Corp. PRESS RELEASE September 29
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561598 Stressgen granted additional patent covering use of lead compound, HspE7. Stressgen Biotechnologies Corp PRESS RELEASE 2004 September 29
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(2004)
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60
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20344395958
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Stressgen's HspE7 treatment showed higher than expected complete response rate among women with high grade cervical dysplasia
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590711 Stressgen Biotechnology Corp. PRESS RELEASE March 21
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590711 Stressgen's HspE7 treatment showed higher than expected complete response rate among women with high grade cervical dysplasia. Stressgen Biotechnology Corp PRESS RELEASE 2005 March 21
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(2005)
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61
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20344388890
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Heat shock protein (Hsp)-based immunotherapy (HspE7) for treatment of CIN III (NCI 5850, NYGOG)
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594967 March 21
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594967 Heat shock protein (Hsp)-based immunotherapy (HspE7) for treatment of CIN III (NCI 5850, NYGOG). SOCIETY OF GYNECOLOGIC ONCOLOGISTS ANNUAL MEETING 2005 March 21
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(2005)
Society if Gynecologic Oncologists Annual Meeting
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62
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20344384617
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Induction of CD4-independent CD8+ memory T cells by HspE7 fusion protein
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594969 July 22
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594969 Induction of CD4-independent CD8+ memory T cells by HspE7 fusion protein. INTERNATIONAL CONGESS ON IMMUNOLOGY 2004 July 22
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(2004)
International Congess on Immunology
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63
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20344378313
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Stressgen announces sale of bioreagents business for approximately CDN$8.0 million and withdraws preliminary prospectus for offering of common shares
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595013 Stressgen Biotechnology Corp. PRESS RELEASE April 13
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595013 Stressgen announces sale of bioreagents business for approximately CDN$8.0 million and withdraws preliminary prospectus for offering of common shares. Stressgen Biotechnology Corp PRESS RELEASE 2005 April 13
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(2005)
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64
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20344405306
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Memory CD8+ T cells induced by HspE7 fusion protein provide protection against tumor challenge
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595452 March 19-24
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595452 Memory CD8+ T cells induced by HspE7 fusion protein provide protection against tumor challenge. KEYSTONE SYMPOSIUM - BASIC ASPECTS OF TUMOR IMMUNOLOGY 2005 March 19-24
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(2005)
Keystone Symposium - Basic Aspects of Tumor Immunology
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65
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20344390609
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HspE7 treatment of pediatric recurrent respiratory papillomatosis (RRP): Interim results utilizing a laryngeal staging and severity scale (LSSS)
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599455 Oral presentation
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599455 HspE7 treatment of pediatric recurrent respiratory papillomatosis (RRP): Interim results utilizing a laryngeal staging and severity scale (LSSS). Derkay CS, Arnold J, Bower C, McClay J, Smith R, Van Burik J, Wiatrak B, Wohl D, Berger B, Neefe J SOC EAR, NOSE THROAT ADV CHILD ANN MEET 2003 Oral presentation
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(2003)
Soc. Ear, Nose Throat Adv. Child Ann. Meet.
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Derkay, C.S.1
Arnold, J.2
Bower, C.3
McClay, J.4
Smith, R.5
Van Burik, J.6
Wiatrak, B.7
Wohl, D.8
Berger, B.9
Neefe, J.10
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