Endogenous morphine and ACTH association in neural tissues

Medical Science Monitor

Volumn 11, Issue 5, 2005, Pages

  Sonetti, Dario ^a   Peruzzi, Elisa ^a   Stefano, George B ^b  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

ACTH; Endogenous morphine; Immunocytochemical colocalizazation; Molluscan CNS; Stress response

Indexed keywords

CORTICOTROPIN; ENDOGENOUS MORPHINE; MORPHINE; MORPHINE LIKE COMPOUND; PROOPIOMELANOCORTIN; PROOPIOMELANOCORTIN DERIVED PEPTIDELIKE MOLECULE; UNCLASSIFIED DRUG;

COMPARATIVE STUDY; CONFERENCE PAPER; DRUG DISTRIBUTION; EVOLUTION; GANGLION; HEMOLYMPH; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; INJURY; INVERTEBRATE; LYMNAEA; LYMNAEA STAGNALIS; MOLLUSC; MYTILUS GALLOPROVINCIALIS; NERVOUS SYSTEM; NERVOUS TISSUE; NEUROENDOCRINE SYSTEM; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; PERIKARYON; PHYLOGENY; PLANORBARIUS CORNEUS; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; RADIOIMMUNOASSAY; SECOND MESSENGER; STRESS; VIVIPARUS ATER;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; BIVALVIA; HEMOLYMPH; IMMUNOHISTOCHEMISTRY; LYMNAEA; MOLLUSCA; MORPHINE; NERVOUS SYSTEM; SNAILS; SPECIES SPECIFICITY;

EID: 20344394677     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (47)

1. Donnerer J, Cardinale G, Coffey J, Lisek CA et al: Chemical characterization and regulation of endogenous morphine and codeine in the rat. J Pharmacol Exp Ther, 1987; 242: 583-87
2. Gintzler AR, Levy A, Spector S: Antibodies as a means of isolating and characterizing biologically active substances: Presence of a non-peptide morphine- like compound in the central nervous system. Proc Natl Acad Sci (USA), 1976; 73: 2132-36
3. Horak P, Haberman F, Spector S: Endogenous morphine and codeine in mice: effect on muramyl dipeptide. Life Sci. 1993; 52: 255-60
4. Lee CS, Spector S: Changes of endogenous morphine and codeine contents in fasting rat. J Pharmacol Exp Ther, 1991; 257: 647-50
5. Oka K, Kantrowitz JD, Spector S: Isolation of morphine from toad skin. Proc Natl Acad Sci (USA), 1985; 82: 1852-54
6. Sonetti D, Mola L, Casares F et al: Endogenous morphine levels increase in molluscan neural and immune tissues after physical trauma. Brain Res. 1999; 835: 137-47
7. Stefano GB, Leung MK, Zhao X, Scharrer B: Evidence for the involvement of opioid neuropeptides in the adherence and migration of immunocompetent invertebrate hemocytes, Proc Natl Acad Sci (USA), 1989a; 80: 626-30
8. Stefano GB, Cadet P, Scharrer B: Stimulatory effects of opioid neuropeptides on locomotory activity and conformational changes in invertebrate and human immunocytes: Evidence for a subtype of delta receptor. Proc Natl Acad Sci (USA), 1989b; 80: 6307-11
9. Stefano GB, Digenis A, Spector S et al: Opiatelike substances in an invertebrate, a novel opiate receptor on invertebrate and human immunocytes, and a role in immunosuppression. Proc Natl Acad Sci (USA), 1993; 90: 11099-103
10. Stefano GB, Scharrer B, Smith EM et al: Opioid and opiate immunoregulatory processes. Crit Rev Immunol. 1996; 16: 109-14
11. Zhu W, Baggerman G, Goumon Y et al: Presence of morphine and morphine-6-glucuronide in the marine mollusk Mytilus edulis ganglia determined by GC/MS and Q-TOF-MS. Starvation increases opiate alkaloid levels. Brain Res Mol Brain Res, 2001; 88: 155-60
12. Duvaux-Miret O, Dissous C, Guatron JP et al: The helminth Schistosoma mansoni expresses a peptide similar 10 human beta-endorphin and possesses a POMC-related gene. New Biol, 1990; 2: 93-99
13. Duvaux-Miret O, Stefano GB, Smith EM et al: Proopiomelanocortin-derived peptides as tools of immune evasion for the human trematode Schistosoma mansoni. Acta Biol Hung, 1992a: 43: 281-80
14. Duvaux-Miret O, Stefano GB, Smith EM, Capron A: Neuroimmunology of host parasite interactions: proopiomelanocortin derivedpeptides in the infection by Schistoma mansoni. Adv Neuroimmunol, 1992b; 2: 297-311
15. Salzet M, Cocquerelle C, Verger-Boccjuet M et al: Leech immunocytes contain proopiomelanocortin: nitric oxide mediates hemolymph POMC processing. J Immunol, 1997; 159: 5400-11
16. Stefano GB, Salzet M, Raveillon B, Salzet M: Mytilus edulis hemolymph contains pro-opiomelanocortin: LPS and morphine stimulate differential processing. Mol Brain Res, 1998; 03: 340-50
17. Stefano GB: Autoimmunovascular regulation: morphine and anandamide stimualted nitric oxide release. J Neuroimmunol, 1998; 83: 70-76
18. Cadet P, Stefano GB: Mytilus edulis pedal ganglia express mu opiate receptor transcripts exhibiting high sequence identity with human neuronal mul. Brain Res Mol Brain Res, 1999; 74: 242-46
19. Cadet P, Zhu W, Mantione KJ et al: Cold stress alters Mytilus edulis pedal ganglia expression of mu opiate receptor transcripts determined by real-time RT-PCR and morphine levels. Brain Res Mol Brain Res. 2002; 99: 26-33
20. Stefano GB, Leung MK, Bilfinger TV, Scharrer B: Effect of prolonged exposure to morphine on responsiveness of human and invertebrate immunocytes to stimulatory molecules. J Neuroimmunol, 1995a; 63: 175-81
21. Cadet P, Mantione KJ, Stefano GB: Molecular identification and functional expression of mu3, a novel alternatively spliced variant of the human mu opiate receptor gene. Journal of Immunology, 2003; 170: 5118-23
22. Zhu W, Ma Y, Stefano GB: Presence of isoquinoline alkaloids in molluscan ganglia. Neuroendocrinol Lett. 2002; 23: 329-34
23. Stefano GB, Scharrer B: The presence of the μ3 opiate receptor in invertebrate neural tissues. Comp Biochem Physiol, 1996; 113C: 369-73
24. Stefano GB, Smith EM: Adrenocorticotropin, a central trigger in immune responsiveness: tonal inhibition of immune activation. Med Hypotheses, 1990; 40: 471-78
25. Zhu W, Stefano GB: Reticuline exposure to invertebrate ganglia increase endogenouse morphine levels. Neuroendocrinol Lett, 2004; 25: 323-30
26. Liu Y, Shenouda D, Bilfinger TV et al: Morphine stimulates nitric oxide release from invertebrate mictoglia. Brain Res, 1996; 722: 125-31
27. Magazine HI, Lin Y, Bilfinger TV et al: Morphine-induced conformational changes in human monocytes, granulocytes, and endothelial cells and in invertebrate immunocytes and microglia are mediated by nitric oxide. J Immunol, 1996; 156: 4845-50
28. Nieto Fernandez FE, Mattocks D, Cavani F et al: Morphine coupling to invertebrate immunocyte nitric oxide release is dependent on intracellular calcium transients. Comp Biochem Physiol B, Biochem Mol Biol, 1999; 123: 295-99
29. Stefano GB, Hartman A, Bilfinger TV et al: Presence of the μ3 opiate receptor in endothelial cells: coupling to nitric oxide production and vasodilation. J Biol Chem, 1995b; 270: 30290-93
30. Sonetti D. Ottaviani E, Bianchi F et al: Microglia in invertebrate ganglia. Proc Natl Acad Sci (USA), 1994; 91: 9180-84
31. Sonetti D, Ottaviani E, Stefano GB: Opiate signaling regulates microglia activities in the invertebrate nervous system. Gen Pharmacol, 1997; 29: 39-47
32. Goumon Y, Casares F, Pryor S et al: Ascaris sumu, an intestinal parasite, produces morphine. J Immunnol, 2000; 165: 339-43
33. Duvaux-Miret O, Stefano GB, Smith EM et al: Immunosuppression in the definitive and intermediate hosts of the human parasite Schistosoma mansoni by release of immunoreactive neuropeptides. Proc Natl Acad Sci (USA), 1992c; 89: 778-81
34. Stefano GB, Salzet M: Invertebrate opioid precursors: evolutionary conservation and the significance of enzymatic processing. Int Rev Cytol, 1999; 187: 201-86
35. Bryant HU, Bernton EW, Kenner JR, Holaday JW: Role of adrenal cortical activation in the immunosuppressive effects of chronic morphine treatment. Endocrinol. 1991; 128: 3253-58
36. Nikolarakis KE, Pfeiffer A, Stalla G, Herz A: The role of CRF in the release of ACTH by opiate agonists and antagonists in rats. Brain Res, 1987; 421: 373-76
37. Nikolarakis KE, Pfeiffer A, Stalla G, Herz A: Facilitation of ACTH secretion by morphine is mediated by activation of CRF releasing neurons and sympathetic neuronal pathways. Brain Res, 1989; 498: 385-88
38. Prevot V, Rialas C, Croix D et al: Morphine and anandamide coupling to nitric oxide stimulated GnRH and CRF release from rat median eminence: neurovascular regulation. Brain Res, 1998; 790: 236-44
39. Stefano GB, Cadet P, Rialas CM: Invertebrate Opiate Immune and Neural Signaling. In: Machelska H, Stein C, editor. Immune Mechanisms of Pain and Analgesia. New York, NY: Plenum Publ.; 2003; 126-47
40. Bouret S, Prevot V, Croix D et al: μ opioid receptor mRNA in proo-piomelanocortin-mRNA expressing rat avcuate nucleus neurons: Autoregulation. Mol Brain Res, 1999; 70: 155-58
41. Bianchi E, Alessandrini C, Guarna M, Tagliamonte A: Endogenous codeine and morphine are stored in specific brain neurons. Brain Res, 1993;627:210-15
42. Bianchi E, Guarna M, Tagliamonte A: Immunocytochemical localization of endogenous codeine and morphine. Adv Neuroimmunol, 1994; 4: 83-92
43. Tagliamonte A, Guarna M, Bianchi E: Endogenous morphine and codeine as possible physiological ligands of -opiate receptors. In: Maremnraui I, Tagliamonte A, editors. Drug addiction and related clinical problems. Wien: Springer-Verlag; 1995; 27-35
44. Stefano GB, Martin R: Enkephalin-like immunoreactivity in the pedal ganglion of Mytilus edulis (Bivalvia) and its proximity to dopamine-containing structures. Cell Tiss Res, 1983; 230: 147-54
45. Smith EM, Hughes TK, Hashemi F, Stefano GB: Immunosuppressive effects of ACTH and MSH and their possible significance in human immunodeficiency virus infection. Proc Natl Acad Sci (USA), 1992; 89: 782-86
46. Stefano GB, Scharrer B: Endogenous morphine and related opiates, a new class of chemical messengers. Adv Neuroimmunol. 1994; 4: 57-68
47. Guarna M, Neri C, Petrioli F, Bianchi E: Potassium-induced release of endogenous morphine form rat brain slices. J Neurochem, 1998; 70: 147-52