Differential inhibition of UVB-induced AP-1 and NF-κB transactivation by components of the jun bZIP domain

Molecular Carcinogenesis

Volumn 43, Issue 2, 2005, Pages 108-116

  Cooper, Simon ^a   Ranger Moore, James ^b   Bowden, Tim G ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

bZIP domain; Leucine zipper domain; TAM67

Indexed keywords

I KAPPA B ALPHA; I KAPPA B BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEUCINE ZIPPER PROTEIN; PROTEIN C JUN; PROTEIN P50; PROTEIN TAM67; SYNAPTOTAGMIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER PREVENTION; CONTROLLED STUDY; GENETIC TRANSFECTION; IMMUNOPRECIPITATION; KERATINOCYTE; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RADIATION EXPOSURE; SKIN CANCER; TRANSACTIVATION; ULTRAVIOLET B RADIATION;

ANIMALS; CELL LINE; CELL NUCLEUS; GENES, JUN; KERATINOCYTES; MICE; NF-KAPPA B; NUCLEAR PROTEINS; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS C-JUN; RNA-BINDING PROTEINS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS; ULTRAVIOLET RAYS;

EID: 20344375923     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/mc.20101     Document Type: Article

References (27)

1. de Gruijl FR, Sterenborg HJ, Forbes PD, et al. Wavelength dependence of skin cancer induction by ultraviolet irradiation of albino hairless mice. Cancer Res 1993;53:53-60.
2. Cole CA, Forbes PD, Davies RE. An action spectrum for UV photocarcinogenesis. Photochem Photobiol 1986;43:275-284.
3. Ananthaswamy HN, Pierceall WE. Molecular mechanisms of ultraviolet radiation carcinogenesis. Photochem Photobiol 1990;52:1119-1136.
4. Chen W, Borchers AH, Dong Z, Powell MB, Bowden GT. UVB irradiation-induced activator protein-1 activation correlates with increased c-fos gene expression in a human keratinocyte cell line. J Biol Chem 1998;273:32176-32181.
5. Bender K, Gottlicher M, Whiteside S, Rahmsdorf HJ, Herrlich P. Sequential DNA damage-independent and -dependent activation of NF-kappaB by UV. Embo J 1998;17:5170-5181.
6. Gilmore TD, Koedood M, Piffat KA, White DW. Rel/NF-kappaB/lkappaB proteins and cancer. Oncogene 1996;13: 1367-1378.
7. Shaulian E, Karin M. AP-1 in cell proliferation and survival. Oncogene 2001;20:2390-2400.
8. Li JJ, Westergaard C, Ghosh P, Colburn NH. Inhibitors of both nuclear factor-kappaB and activator protein-1 activation block the neoplastic transformation response. Cancer Res 1997;57:3569-3576.
9. Steinmuller L, Cibelli G, Moll JR, Vinson C, Thiel G. Regulation and composition of activator protein 1 (AP-1) transcription factors controlling collagenase and c-jun promoter activities. Biochem J 2001;360:599-607.
10. Domann FE, Jr, Levy JP, Finch JS, Bowden GT. Constitutive AP-1 DNA binding and transactivating ability of malignant but not benign mouse epidermal cells. Mol Carcinog 1994; 9:61-66.
11. Bernstein LR, Colburn NH. AP1/jun function is differentially induced in promotion-sensitive and resistant JB6 cells. Science 1989;244:566-569.
12. Young MR, Li JJ, Rincon M, et al. Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion. Proc Natl Acad Sci USA 1999;96:9827-9832.
13. Thompson EJ, MacGowan J, Young MR, Colburn N, Bowden GT. A dominant negative c-jun specifically blocks okadaic acid-induced skin tumor promotion. Cancer Res 2002;62: 3044-3047.
14. Cooper SJ, MacGowan J, Ranger-Moore J, Young MR, Colburn NH, Bowden GT. Expression of dominant negative c-jun inhibits ultraviolet B-induced squamous cell carcinoma number and size in an SKH-1 hairless mouse model. Mol Cancer Res 2003;1:848-854.
15. Budunova IV, Perez P, Vaden VR, Spiegelman VS, Slaga TJ, Jorcano JL. Increased expression of p50-NF-kappaB and constitutive activation of NF-kappaB transcription factors during mouse skin carcinogenesis. Oncogene 1999;18: 7423-7431.
16. Bell S, Degitz K, Quirling M, Jilg N, Page S, Brand K. Involvement of NF-kappaB signalling in skin physiology and disease. Cell Signal 2003;15:1-7.
17. Hsu TC, Nair R, Tulsian P, et al. Transformation nonresponsive cells owe their resistance to lack of p65/nuclear factor-kappaB activation. Cancer Res 2001;61:4160-4168.
18. Hsu TC, Young MR, Cmarik J, Colburn NH. Activator protein 1 (AP-1) and nuclear factor kappaB (NF-kappaB)-dependent transcriptional events in carcinogenesis. Free Radic Biol Med 2000;28:1338-1348.
19. Stein B, Baldwin AS, Jr, Ballard DW, Greene WC, Angel P, Herrlich P. Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function. Embo J 1993;12:3879-3891.
20. Yang X, Chen Y, Gabuzda D. ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaB. J Biol Chem 1999;274:27981-27988.
21. Rahmani M, Peron P, Weitzman J, Bakiri L, Lardeux B, Bernuau D. Functional cooperation between JunD and NF-kappaB in rat hepatocytes. Oncogene 2001;20:5132-5142.
22. Li JJ, Cao Y, Young MR, Colburn NH. Induced expression of dominant-negative c-jun downregulates NFkappaB and AP-1 target genes and suppresses tumor phenotype in human keratinocytes. Mol Carcinog 2000;29:159-169.
23. Smeal T, Binetruy B, Mercola DA, Birrer M, Karin M. Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature 1991; 354:494-496.
24. Binetruy B, Smeal T, Karin M. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature 1991;351:122-127.
25. Hu CD, Chinenov Y, Kerppola TK. Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementation. Mol Cell 2002; 9:789-798.
26. Thompson EJ, Gupta A, Stratton MS, Bowden GT. Mechanism of action of a dominant negative c-jun mutant in inhibiting activator protein-1 activation. Mol Carcinog 2002;35: 157-162.
27. Nagasaki K, Schem C, von Kaisenberg C, et al. Leucine-zipper protein, LDOC1, inhibits NF-kappaB activation and sensitizes pancreatic cancer cells to apoptosis. Int J Cancer 2003;105: 454-458.