A family-based association study does not support DYX1C1 on 15q21.3 as a candidate gene in developmental dyslexia

European Journal of Human Genetics

Volumn 13, Issue 4, 2005, Pages 491-499

  Marino, Cecilia ^a   Giorda, Roberto ^a   Lorusso, Maria Luisa ^a   Vanzin, Laura ^a   Salandi, Nello ^a   Nobile, Maria ^a   Citterio, Alessandra ^a   Beri, Silvana ^a   Crespi, Valentina ^a   Battaglia, Marco ^b,c   Molteni, Massimo ^a  

^a SCIENTIFIC INSTITUTE   (Italy)

^b VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^c NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

Author keywords

Developmental dyslexia; DYX1C1; Family based association study; Quantitative analysis

Indexed keywords

ADENINE; CYTOSINE; DYX1C1 PROTEIN; GUANINE; NUCLEAR PROTEIN; TETRATRICOPEPTIDE REPEAT PROTEIN; THYMINE; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME 15Q; COMPUTER PROGRAM; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DYSLEXIA; EXON; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC MARKER; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; NUCLEIC ACID BASE SUBSTITUTION; PHENOTYPE; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; CHILD; CHROMOSOMES, HUMAN, PAIR 15; DYSLEXIA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; NERVE TISSUE PROTEINS; NUCLEAR FAMILY; NUCLEAR PROTEINS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 20244377078     PISSN: 10184813     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejhg.5201356     Document Type: Article

References (42)

1. Fisher SE, De Fries JC: Developmental dyslexia: genetic dissection of a complex cognitive trait. Nat Rev Neurosci 2002; 3: 767-780.
2. Facoetti A: Reading and selective spatial attention: evidence from behavioral studies in dyslexic children; in Progress in dyslexia research. Hauppauge, NY: Nova Science Publishers, 2004, in press.
3. Stein J: Visual motion sensitivity and reading. Neuropsychologia 2003; 41: 1785-1793.
4. Habib M: The neurological basis of developmental dyslexia: an overview and working hypothesis. Brain 2000; 12: 2373-2399.
5. Rabin M, Wen XL, Hepburn M: Suggestive linkage of developmental dyslexia to chromosome 1p34-p36. Lancet 1993; 342 178.
6. Grigorenko EL, Wood FB, Meyer MS et at: Linkage studies suggest a possible locus for developmental dyslexia on chromosome 1p. Am J Med Genet 2001; 105: 120-129.
7. Fagerheim T, Raeymaekers P, Tonnessen FE et al: A new gene (DYX3) for dyslexia is located on chromosome 2. J Med Genet 1999; 36: 664-669.
8. Francks C, Fisher SE, Olson RK et al: Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1. Psychiatry Genet 2002; 12: 35-41.
9. Petryshen TL, Kaplan BJ, Hughes ML et al: Supportive evidence for the DYX3 dyslexia susceptibility gene in Canadian families. J Med Genet 2002; 39: 125-126.
10. Nopola-Hemmi J, Myllyluoma B, Haltia T et al: A dominant gene for developmental dyslexia on chromosome 3. J Med Genet 2001; 38: 658-664.
11. Cardon LR, Smith SD, Fulker DW: Quantitative trait locus for reading disability on chromosome 6. Science 1994; 266: 2276-2279.
12. Cardon LR, Smith SD, Fulker DW: Quantitative trait locus for reading disability: a correction. Science 1995; 268: 5217.
13. Grigorenko EL, Wood FB, Meyer SB et al: Susceptibility loci for distinct components of developmental dyslexia on chromosome 6 and 15. Am J Hum Genet 1997; 60: 27-39.
14. Fisher SE, Marlow AJ, Lamb J et al: A quantitative trait locus on chormosome 6 influences different aspects of developmental dyslexia. Am J Hum Genet 1999; 64: 146-156.
15. Gayàn J, Smith SD, Cherny SS et al: Quantitative trait locus for specific language and reading deficits in chromosome 6p. Am J Hum Genet 1999; 64: 157-164.
16. Grigorenko EL, Wood FB, Meyer MS et al: Chromosome 6p influences on different dyslexia-related cognitive processes: further confirmation. Am J Hum Genet 2000; 66: 715-723.
17. Kaplan DE, Gayan J, Ahn J et al: Evidence for linkage and association with reading disability on 6p21.3-22. Am J Hum Genet 2002; 70: 1287-1298.
18. Turic D, Robinson L, Duke M et al: Linkage disequilibrium mapping provides further evidence of a gene for reading disability on chromosome 6p21.3-22. Mol Psychiatry 2003; 8: 176-185.
19. Petryshen TL, Kaplan BJ, Fu Liu M et al: Evidence for a susceptibility locus on chromosome 6q influencing phonological coding dyslexia. Am J Med Genet 2001; 105: 507-517.
20. Smith SD, Kimberling WJ, Pennington BF et al: Specific reading disability-identification of an inherited form through linkage analysis. Science 1983; 219: 1345.
21. Smith SD, Kimberling WJ, Pennington BF: Screening for multiple genes influencing dyslexia. Read Writ 1991; 3: 285-298.
22. Fulker DW: Multiple regression of sib-pair data on reading to detect quantitative trait loci. Read Writ 1991; 3: 299-313.
23. Schulte-Korne G, Grimm T, Nothen MM et al: Evidence for linkage of spelling disability to chromosome 15. Am J Hum Genet 1998; 63: 279-282.
24. Morris DW, Robinson L, Turic D et al: Family-based association mapping provides evidence for a gene for reading disability on chromosome 15q. Hum Mol Genet 2000; 9: 843-848.
25. Nopola-Hemmi J, Taipale M, Haltia T et al: Two translocations of chromosome 15q associated with dyslexia. J Med Genet 2000; 37: 771-775.
26. Marino C, Giorda R, Vanzin L et al: A locus on 15q15-15qter influences dyslexia: further support from a transmission/disequilibrium study in an Italian speaking population. J Med Genet 2004; 41: 42-46.
27. Fisher SE, Francks C, Marlow AJ et al: Independent genome-wide scans identify a chromosome 18 quantitative-trait locus influencing dyslexia. Nat Genet 2002; 30: 86-91.
28. Taipale M, Kaminen N, Nopola-Hemmi J et al: A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain. Proc Natl Acad Sci USA 2003; 20: 11553-11558.
29. Wigg KG, Couto JM, Feng Y et al: Support for EKN1 as the susceptibility locus for dyslexia on 15q21. Mol Psychiatry 2004; July 13; [E-pub ahead of print].
30. Marino C, Giorda R, Vanzin L et al: No evidence for association and linkage disequilibrium between dyslexia and markers of four dopamine-related genes. Eur Child Adolesc Psychiatry 2003; 4: 198-202.
31. American Psychiatric Association: Diagnostic and statistical manual of mental disorders. Fourth Edition. Washington DC: American Psychiatric Association, 1994.
32. Sartori G, Job R, Tressoldi PE: Batteria per la valutazione della dislessia e della disortografia evolutiva. Firenze: Organizzazioni Speciali, 1995.
33. Cornoldi C, Colpo G, Gruppo MT: Prove di lettura. Firenze: Organizzazioni Speciali, 1986.
34. Wechsler D: Examiner's manual. Wechsler Intelligence Scale for Children, Revised. New York: Psychological Corp., 1981.
35. Dracopoli NC, Haines JL, Korf BR et al: Current Protocols in Human Genetics 2004, Unit 9.7. New York: Wiley.
36. Spielman RS, McGinnis RE, Ewens WJ: Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993; 52: 506-516.
37. Horvath S, Xu X, Laird N: The family based association test method: strategies for studying general genotype-phenotype associations. Eur J Hum Genet 2001; 9: 301-306.
38. Horvath S, Xu X, Lake SL et al: Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol 2004; 26: 61-69.
39. Pennington BF: Genetics of learning disabilities. J Child Neurol 1995; 10: S69-S77.
40. Clayton D, Jones H: Transmission/disequilibrium tests for extended marker haplotypes. Am J Hum Genet 1999; 65: 1161-1169.
41. Clayton D: A generalization of the transmission/disequilibrium test for uncertain haplotype transmission. Am J Hum Genet 1999; 65: 1170-1177.
42. Zhao H, Zhang S, Merikangas KR et al: Transmission disequilibrium test using multiple tightly linked markers. Am J Hum Genet 2000; 67: 936-946.