Association between neuroleptic drug-induced extrapyramidal symptoms and dopamine D2-receptor polymorphisms in Japanese schizophrenic patients

International Journal of Clinical Pharmacology and Therapeutics

Volumn 43, Issue 4, 2005, Pages 163-171

  Nakazono, Y ^a   Abe, H ^b   Murakami, H ^a   Koyabu, N ^a   Isaka, Y ^b   Nemoto, Y ^b   Murata, S ^b   Tsutsumi, Y ^b   Ohtani, H ^a   Sawada, Y ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b Ongata Hospital   (Japan)

Author keywords

141C Ins Del; Dopamin D2 receptor gene (DRD2) polymorphisms; Extrapyramidal adverse effects; Taq1A; Taq1B

Indexed keywords

ANTIPARKINSON AGENT; BIPERIDEN; BROMPERIDOL; CHLORPROMAZINE; CLOSPIPRAMINE; DOPAMINE 2 RECEPTOR; ETIZOLAM; FLUNITRAZEPAM; FLURAZEPAM; FLUVOXAMINE; HALOPERIDOL; LEVOMEPROMAZINE; NEUROLEPTIC AGENT; NITRAZEPAM; PERICIAZINE; PEROSPIRONE; PROMETHAZINE; QUETIAPINE; RILMAZAFONE; RISPERIDONE; SULPIRIDE; SULTOPRIDE; THIORIDAZINE; TIMIPERONE; TRIAZOLAM; TRIHEXYPHENIDYL; TRIMEBUTINE; UNINDEXED DRUG; VALPROIC ACID; ZOTEPINE;

ADULT; AGED; ALLELE; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; DNA ISOLATION; EXTRAPYRAMIDAL SYMPTOM; FEMALE; GENE DELETION; GENE FREQUENCY; GENE INSERTION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HEBEPHRENIA; HUMAN; INFORMED CONSENT; JAPAN; MAINTENANCE DRUG DOSE; MALE; PARANOID SCHIZOPHRENIA; RESIDUAL SCHIZOPHRENIA; SCHIZOPHRENIA; SCORING SYSTEM;

EID: 20244373032     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CPP43163     Document Type: Article

References (28)

1. 2-receptor molecular variant with schizophrenia. Lancet 343: 703-704
2. 2-receptor gene is associated with schizophrenia. Hum Mol Genet 6: 577-582
3. Avon J, Bohn RH, Mogun H, Gurwitz JH, Monane M, Everitt D, Walker A 1995 Neuroleptic drug exposure and treatment of parkinsonism in the elderly: a case-control study. Am J Med 99: 48-54
4. Binder RL, Kazamatsuri H, Nakashima T, McNiel DE 1987 Tardive dyskinesia and neuroleptic-induced parkinsonism in Japan. Am J Psychiatry 144: 1494-1496
5. Breen G, Brown I, Maude S, Fox H, Collier D, Li T 1999 -141C del/ins polymorphism of the dopamine receptor 2 gene is associated with schizophrenia in a British population. Am J Med Gen 88: 407-410
6. 2-receptor locus. Biol Psychiatry 34: 204-209
7. 2-receptor gene and tardive dyskinesia in schizophrenia. Biol Psychiatry 41: 827-829
8. 2-receptor missense variants. J Biol chem 271: 26013-26017
9. Inada T 1996 Evaluation and diagnosis of drug-induced extrapyramidal symptoms: commentary on the DIEPSS and guide to its usage. Seiwa Publishers Inc, Tokyo
10. 2-receptor gene and schizophrenia in Japanese subjects: replication and evaluation for antipsychotic-related features. Int J Neuropsychopharmacology 2: 181-186
11. Inagaki A, Inada T, Fuzii Y, Yagi K, Yosio T, Nakamura H, Yamauchi T 1999 Equivalent of antipsychotic. Seiwa Publishers Inc, Tokyo
12. 2 (Ser311->Cys). Biochem Biophys Res Commun 196: 1369-1375
13. 2-receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers. Mol Psychiatry 4: 290-296
14. 2-receptor gene and schizophrenia. Schizophrenia Research 40: 31-36
15. 2-receptor polymorphisms in patients with schizophrenia. Mol Psychiatry 7: 695-705
16. Kapur S, Zipursky R, Jones C, Remington G, Houle S 2000 Relationship between dopamine D2 occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia. Am J Psychiatry 157: 514-520
17. Kay SR, Fiszbein A, Opler LA 1987 The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13: 261-276
18. 2-receptor gene. Mol Psychiatry 3: 261-265
19. 2-receptor gene (DRD2) in 3 distinct Taiwanese populations. Biol Psychiatry 39: 419-429
20. Mihara K, Suzuki A, Kondo T, Nagashima U, Ono S, Otani K, Kaneko S 2000 No relationship between Taq1 A polymorphism of dopamine D(2) receptor gene and extrapyramidal adverse effects of selective dopamine D(2) antagonists, bromperidol, and nemonapride in schizophrenia: a preliminary study. Am J Med Genet 96: 422-424
21. 2-receptor and extrapyramidal adverse effects of selective dopamine D2 antagonists in schizophrenic patients: a preliminary study. Psychiatry Res 101: 117-123
22. Otani K, Aoshima T 2000 Pharmacogenetics of classical and new antipsychotic drugs. Ther Drug Monit 22: 118-121
23. Overall JE, Gorham DR 1962 The brief psychiatric rating scale. Psychol Rep 10: 799-812
24. 2-receptor availability in healthy volunteers. Mol Psychiatry 3: 256-260
25. 2-receptor gene is a susceptibility locus for Parkinson's disease. Mov Disord 15: 127-131
26. Suzuki A, Otani K, Mihara K, Yasui N, Kaneko S, Inoue Y, Hayashi K 1997 Effects of the CYP2D6 genotypes on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese schizophrenic patients. Pharmacogenetics 7: 415-418
27. 2-receptor promoter polymorphism: no association with schizophrenia. Psychiatry Res 85: 215-219
28. 2-receptor binding in the human striatum associated with the A1 allele. Pharmacogenetics 7: 479-484