Neonatal hyperbilirubinemia and the bilirubin uridine diphosphate- glucuronosyltransferase gene: The common -3263T > G mutation of phenobarbital response enhancer module is not associated with the neonatal hyperbilirubinemia in Japanese

Pediatrics International

Volumn 47, Issue 2, 2005, Pages 137-141

  Kanai, Masayo ^a   Kijima, Kazuki ^a   Shirahata, Emi ^a   Sasaki, Ayako ^a   Akaba, Kazuhiro ^a   Umetsu, Kazuo ^a   Tezuka, Naohiro ^a   Kurachi, Hirohisa ^a   Aikawa, Shogo ^b   Hayasaka, Kiyoshi ^a  

^a YAMAGATA UNIVERSITY   (Japan)

^b YAMAGATA PREFECTURAL INSTITUTE OF PUBLIC HEALTH   (Japan)

Author keywords

Bilirubin uridine diphosphate glucuronosyltransferase; Gilbert syndrome; Neonatal hyperbilirubinemia; Phenobarbital response enhancer

Indexed keywords

ADENINE; BILIRUBIN; BILIRUBIN URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE; GUANINE; PHENOBARBITAL; THYMINE; UNCLASSIFIED DRUG;

ANALYTICAL EQUIPMENT; ARTICLE; BILIRUBIN BLOOD LEVEL; BILIRUBIN URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE GENE; CHINA; CONTROLLED STUDY; DISEASE SEVERITY; DRUG RESPONSE; ENHANCER REGION; GENE; GENE FREQUENCY; GENE MUTATION; GERMANY; GILBERT DISEASE; HUMAN; JAPAN; KOREA; MAJOR CLINICAL STUDY; NEWBORN; NEWBORN JAUNDICE; PHENOBARBITAL RESPONSE ENHANCER MODULE; PHOTOTHERAPY; PREVALENCE; PRIORITY JOURNAL; RACE; RESTRICTION MAPPING; SEQUENCE ANALYSIS;

ASIAN CONTINENTAL ANCESTRY GROUP; GENE FREQUENCY; GILBERT DISEASE; GLUCURONOSYLTRANSFERASE; HUMANS; INFANT, NEWBORN; JAPAN; JAUNDICE, NEONATAL; MUTATION, MISSENSE; OPEN READING FRAMES; PHENOBARBITAL; PHOTOTHERAPY; PROMOTER REGIONS (GENETICS); RESPONSE ELEMENTS; SEROEPIDEMIOLOGIC STUDIES;

EID: 20244362527     PISSN: 13288067     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1442-200x.2005.02030.x     Document Type: Article

References (14)

1. Maisels MJ. Epidemiology and causes of indirect hyperbilirubinemia. In: Maisels MJ, Watchko JF (eds). Neonatal Jaundice. Harwood Academic Publishers, Amsterdam, 2000; 37-49.
2. Halamek LP, Stevenson DK. Neonatal jaundice and liver disease. In: Fanaroff AA, Martin RJ (eds). Neonatal-Perinatal Medicine. Mosby-Year Book, St. Louis, 1997; 1345-89.
3. Kawade N, Onishi S. The prenatal and postnatal development of UDP glucuronyltransferase activity towards bilirubin and the effect of premature birth on this activity in the human liver. Biochem. J. 1981; 196: 257-60.
4. Bancroft JD, Kreamer B, Gourley GR. Gilbert syndrome accelerates development of neonatal jaundice. J. Pediatr. 1998; 132: 656-60.
5. Akaba K, Kimura T, Sasaki A et al. Neonatal hyperbilirubinemia and mutation of the bilirubin uridine diphosphate-glucuronosyltransferase gene: a common missense mutation among Japanese, Koreans and Chinese. Biochem. Mol. Biol. Int. 1998; 46: 21-6.
6. Akaba K, Kimura T, Sasaki A et al. Neonatal hyperbilirubinemia and a common mutation of the bilirubin uridine diphosphate-glucuronosyltransferase gene in Japanese. J. Hum. Genet. 1999; 44: 22-5.
7. Sugatani J, Yamakawa K, Yoshinari K et al. Identification of a defect in the UGT1A1 gene promoter and its association with hyperbilirubinemia. Biochem. Biophys. Res. Commun. 2002; 292: 492-7.
8. Sugatani J, Kojima H, Ueda A et al. The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. Hepatology 2001; 33: 1232-8.
9. Bartoletti AL, Stevenson DK, Ostrander CR, Johnson JD. Pulmonary excretion of carbon monoxide in the human infant as an index of bilirubin production. I. Effects of gestational and postnatal age and some common neonatal abnormalities. J. Pediatr. 1979; 94: 952-5.
10. Stevenson DK, Vreman HJ, Wong RJ, Contag C. Carbon monoxide and bilirubin production in neonates. Semin. Perinatol. 2001; 25: 85-93.
11. Fischer AF, Nakamura H, Uetani Y, Vreman HJ, Stevenson DK. Comparison of bilirubin production in Japanese and Caucasian infants. J. Pediatr. Gastroenterol. Nutr. 1988; 7: 27-9.
12. Kanai M, Akaba K, Sasaki A et al. Neonatal hyperbilirubinemia in Japanese neonates: analysis of the heme oxygenase-1 gene and fetal hemoglobin composition in cord blood. Pediatr. Rex. 2003; 54: 165-71.
13. Stevenson DK. The carboxyhemoglobin method for estimating bilirubin production in neonates. Japanese studies. Clin. Pediatr. (Phila) 1992; 31: 708-11.
14. Kaplan M, Hammerman C, Rubaltelli FF et al. Hemolysis and bilirubin conjugation in association with UDP-glucuronosyltransferase 1A1 promoter polymorphism. Hepatology 2002; 35: 905-10.