Common genetic changes in hereditary and sporadic pituitary adenomas detected by comparative genomic hybridization

Genes Chromosomes and Cancer

Volumn 43, Issue 1, 2005, Pages 72-82

  Pack, Svetlana D ^a,b   Qin, Liu Xiu ^c   Pak, Evgenia ^f   Wang, Yun ^d   Ault, David O ^e   Mannan, Poonam ^b   Jaikumar, Sivakumar ^b   Stratakis, Constantine A ^g   Oldfield, Edward H ^b   Zhuang, Zhengping ^b   Weil, Robert J ^b,h  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c FUDAN UNIVERSITY   (China)

^d GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

^f NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^g EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^h LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CARNEY COMPLEX; CHILD; CHROMOSOME 10P; CHROMOSOME 11P; CHROMOSOME 12; CHROMOSOME 13Q; CHROMOSOME 16P; CHROMOSOME 17; CHROMOSOME 19; CHROMOSOME 1P; CHROMOSOME 20; CHROMOSOME 22Q; CHROMOSOME 4; CHROMOSOME 4Q; CHROMOSOME 5; CHROMOSOME 6Q; CHROMOSOME 9P; CHROMOSOME ABERRATION; CHROMOSOME LOSS; CHROMOSOME REARRANGEMENT; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOPHYSIS ADENOMA; MALE; MULTIPLE ENDOCRINE NEOPLASIA; PRIORITY JOURNAL;

ADENOMA; ADOLESCENT; ADULT; CHILD, PRESCHOOL; CHROMOSOME DELETION; CHROMOSOME MAPPING; DNA, NEOPLASM; FEMALE; HUMANS; MALE; MIDDLE AGED; NUCLEIC ACID HYBRIDIZATION; PITUITARY NEOPLASMS;

EID: 20144388511     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.20162     Document Type: Article

References (63)

1. Alexander JM. 2001. Tumor suppressor loss in pituitary tumors. Brain Pathol 11:342-355.
2. Asa SL, Ezzat S. 2002. The pathogenesis of pituitary tumours. Nat Rev Cancer 2:836-849.
3. Bates AS, Farrell WE, Bicknell EJ, McNicol AM, Talbot AJ, Broome JC, Perrett CW, Thakker RV, Clayton RN. 1997. Allelic deletion in pituitary adenomas reflects aggressive biological activity and has potential value as a prognostic marker. J Clin Endocrinol Metab 82:818-824.
4. Boggild MD, Jenkinson S, Pistorello M, Boscaro M, Scanarini M, McTernan P, Perrett CW, Thakker RV, Clayton RN. 1994. Molecular genetic studies of sporadic pituitary tumors. J Clin Endocrinol Metab 78:387-392.
5. Bystrom C, Larsson C, Blomberg C, Sandelin K, Falkmer U, Skogseid B, Oberg K, Werner S, Nordenskjold M. 1990. Localization of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumors. Proc Natl Acad Sci USA 87:1968-1972.
6. Casey M, Vaughan CJ, He J, Hatcher CJ, Winter JM, Weremowicz S, Montgomery K, Kucherlapati R, Morton CC, Basson CT. 2000. Mutations in the protein kinase A R1alpha regulatory subunit cause familial cardiac myxomas and Carney complex. J Clin Invest 106:R31-R38.
7. Chandrasekharappa SC, Guru SC, Manickam P, Olufemi SE, Collins ES, Emmert-Buck MR, Debelenko LV, Zhuang Z, Lubensky IA, Liotta LA, Crabtree JS, Wang Y, Roe BA, Weisemann J, Boguski MS, Agarwal SK, Kester MB, Kim YS, Heppner C, Dong Q, Spiegel AM, Burns AL, Marx SJ. 1997. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 276:404-407.
8. Clayton RN, Boggild M, Bates AS, Bicknell J, Simpson D, Farrell W. 1997. Tumour suppressor genes in the pathogenesis of human pituitary tumours. Horm Res 47:185-193.
9. Clementi E, Malgaretti N, Meldolesi J, Taramelli R. 1990. A new constitutiveiy activating mutation of the Gs protein alpha subunit-gsp oncogene is found in human pituitary tumours. Oncogene 5:1059-1061.
10. Daniely M, Aviram A, Adams EF, Buchfelder M, Barkai G, Fahlbusch R, Goldman B, Friedman E. 1998. Comparative genomic hybridization analysis of nonfunctioning pituitary tumors. J Clin Endocrinol Metab 83:1801-1805.
11. Evans CO, Brown MR, Parks JS, Oyesiku NM. 2000. Screening for MEN1 tumor suppressor gene mutations in sporadic pituitary tumors. J Endocrinol Invest 23:304-309.
12. Fan X, Paetau A, Aalto Y, Vatimaki M, Sane T, Poranen A, Castresana JS, Knuutila S. 2001. Gain of chromosome 3 and loss of 13q are frequent alterations in pituitary adenomas. Cancer Genet Cytogenet 128:97-103.
13. Farrell WE, Clayton RN. 2000. Molecular pathogenesis of pituitary tumors. Front Neuroendocrinol 21:174-198.
14. Farrell WE, Simpson DJ, Bicknell J, Magnay JL, Kyrodimou E, Thakker RV, Clayton RN. 1999. Sequence analysis and transcript expression of the MEN1 gene in sporadic pituitary tumours. Br J Cancer 80:44-50.
15. Goelz SE, Hamilton SR, Vogelstein B. 1985. Purification of DNA from formaldehyde fixed and paraffin embedded human tissue. Biochem Biophys Res Commun 130:118-126.
16. Harada K, Nishizaki T, Ozaki S, Kubota H, Okamura T, Ito H, Sasaki K. 1999. Cytogenetic alterations in pituitary adenomas detected by comparative genomic hybridization. Cancer Genet Cytogenet 112:38-41.
17. Hui AB, Pang JC, Ko CW, Ng HK. 1999. Detection of chromosomal imbalances in growth hormone-secreting pituitary tumors by comparative genomic hybridization. Hum Pathol 30:1019-1023.
18. Kallioniemi A, Kallioniemi OP, Sudar D, Rutovitz D, Gray JW, Waldman F, Pinkel D. 1992. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science 258:818-821.
19. Kallioniemi OP, Kallioniemi A, Piper J, Tanner M, Stokke T, Chen L, Smith HS, Pinkel D, Gray JW, Waldman FM. 1994. Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proc Natl Acad Sci USA 91:2156-2160.
20. Kirschner LS, Carney JA, Pack SD, Taymans SE, Giatzakis C, Cho YS, Cho-Chung YS, Stratakis CA. 2000. Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex. Nat Genet 26:89-92.
21. Kontogeorgos G, Kapranos N, Orphanidis G, Rologis D, Kokka E. 1999. Molecular cytogenetics of chromosome 11 in pituitary adenomas: a comparison of fluorescence in situ hybridization and DNA ploidy study. Hum Pathol 30:1377-1382.
22. Korbonits M, Chahal HS, Kaltsas G, Jordan S, Urmanova Y, Khalimova Z, Harris PE, Farrell WE, Claret FX, Grossman AB. 2002. Expression of phosphorylated p27(Kip1) protein and Jun activation domain-binding protein 1 in human pituitary tumors. J Clin Endocrinol Metab 87:2635-2643.
23. Kovacs K, Scheithauer BW, Horvath E, Lloyd RV. 1996. The World Health Organization classification of adenohypophysial neoplasms. A proposed five-tier scheme. Cancer 78:502-510.
24. Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L. 1989. GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature 340:692-696.
25. Lengauer C, Kinzler KW, Vogelstein B. 1998. Genetic instabilities in human cancers. Nature 396:643-649.
26. Levy A, Lightman S. 2003. Molecular deficits in the pathogenesis of pituitary tumors. Front Neuroendocrinol 24:94-127.
27. Lyons J, Landis CA, Harsh G, Vallar L, Grunewald K, Feichtinger H, Duh QY, Clark OH, Kawasaki E, Bourne HR, et al. 1990. Two G protein oncogenes in human endocrine tumors. Science 249:655-659.
28. Melmed S. 2003. Mechanisms for pituitary tumorigenesis: the plastic pituitary. J Clin Invest 112:1603-1618.
29. Metzger AK, Mohapatra G, Minn YA, Bollen AW, Lamborn K, Waldman FM, Wilson CB, Feuerstein BG. 1999. Multiple genetic aberrations including evidence of chromosome 11q13 rearrangement detected in pituitary adenomas by comparative genomic hybridization. J Neurosurg 90:306-314.
30. Nam DH, Song SY, Park K, Kim MH, Suh YL, Lee JI, Kim JS, Hong SC, Shin HJ, Eoh W, Kim JH. 2001. Clinical significance of molecular genetic changes in sporadic invasive pituitary adenomas. Exp Mol Med 33:111-116.
31. Nasmyth K. 2002. Segregating sister genomes: the molecular biology of chromosome separation. Science 297:559-565.
32. Pack SD, Zbar B, Pak E, Ault DO, Humphrey JS, Pham T, Hurley K, Weil RJ, Park WS, Kuzmin I, Stolle C, Glenn G, Liotta LA, Lerman MI, Klausner RD, Linehan WM, Zhuang Z. 1999a. Constitutional von Hippel-Lindau (VHL) gene deletions detected in VHL families by fluorescence in situ hybridization. Cancer Res 59:5560-5564.
33. Pack SD, Karkera JD, Zhuang Z, Pak ED, Balan KV, Hwu P, Park WS, Pham T, Ault DO, Glaser M, Liotta L, Detera-Wadleigh SD, Wadleigh RG. 1999b. Molecular cytogenetic fingerprinting of esophageal squamous cell carcinoma by comparative genomic hybridization reveals a consistent pattern of chromosomal alterations. Genes Chromosomes Cancer 25:160-168.
34. Pack SD, Kirschner LS, Pak E, Zhuang Z, Carney JA, Stratakis CA. 2000. Genetic and histologic studies of somatomammotropic pituitary tumors in patients with the "complex of spotty skin pigmentation, myxomas, endocrine overactivity and schwannomas" (Carney complex). J Clin Endocrinol Metab 85:3860-3865.
35. Pei L, Melmed S. 1997. Isolation and characterization of a pituitary tumor-transforming gene (PTTG). Mol Endocrinol 11:433-441.
36. Pei L, Melmed S, Scheithauer B, Kovacs K, Benedict WF, Prager D. 1995. Frequent loss of heterozygosity at the retinoblastoma susceptibility gene (RB) locus in aggressive pituitary tumors: evidence for a chromosome 13 tumor suppressor gene other than RB. Cancer Res 55:1613-1616.
37. Poncin J, Stevenaert A, Beckers A. 1999. Somatic MEN1 gene mutation does not contribute significantly to sporadic pituitary tumorigenesis. Eur J Endocrinol 140:573-576.
38. Prezant TR, Levine J, Melmed S. 1998. Molecular characterization of the men1 tumor suppressor gene in sporadic pituitary tumors. J Clin Endocrinol Metab 83:1388-1391.
39. Prezant TR, Kadioglu P, Melmed S. 1999. An intronless homolog of human proto-oncogene hPTTG is expressed in pituitary tymors: evidence for hPTTG family. J Clin Endocrinol Metab 84:1149-1152.
40. Ramaswamy S, Ros KN, Lander ES, Golub TR. 2003. A molecular signature of metastasis in primary solid tumors. Nat Genet 33:49-54.
41. Rickert CH, Dockhorn-Dworniczak B, Bush G, Maskopp D, Albert FK, Rama B, Paulus W. 2001. Increased chromosomal imbalances in recurrent pituitary adenomas. Acta Neuropathol 102:615-620.
42. Ried T, Knutzen R, Steinbeck R, Blegen H, Schrock E, Heselmeyer K, du Manoir S, Auer G. 1996. Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors. Genes Chromosomes Cancer 15:234-245.
43. Saez C, Japon MA, Ramos-Morales F, Romero F, Segura DI, Tortolero M, Pintor-Toro JA. 1999. hpttg Is over-expressed in pituitary adenomas and other primary epithelial neoplasias. Oncogene 18:5473-5476.
44. Sandrini F, Kirschner LS, Bei T, Farmakidis C, Yasufuku-Takano J, Takano K, Prezant TR, Marx SJ, Farrell WE, Clayton RN, Groussin L, Bertherat J, Stratakis CA. 2002. PRKAR1A, one of the Carney complex genes, and its locus (17q22-24) are rarely altered in pituitary tumours outside the Carney complex. J Med Genet 39:e78.
45. Schmidt MC, Henke RT, Stangl AP, Meyer-Puttlitz B, Stoffel-Wagner B, Schramm J, von Deimling A. 1999. Analysis of the MEN1 gene in sporadic pituitary adenomas. J Pathol 188:168-173.
46. Schwindinger WF, Francomano CA, Levine MA. 1992. Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome. Proc Natl Acad Sci USA 89:5152-5156.
47. Simpson DJ, Hibberts NA, McNicol AM, Clayton RN, Farrell WE. 2000. Loss of pRb expression in pituitary adenomas is associated with methylation of the RB1 CpG island. Cancer Res 60:1211-1216.
48. Stratakis CA, Schussheim DH, Freedman SM, Keil MF, Pack SD, Agarwal SK, Skarulis MC, Weil RJ, Lubensky IA, Zhuang Z, Oldfield EH, Marx SJ. 2000. Pituitary macroadenoma in a 5-year-old: an early expression of multiple endocrine neoplasia type 1. J Clin Endocrinol Metab 85:4776-4780.
49. Struski S, Doco-Fenzy M, Cornillet-Lefebvre P. 2002. Compilation of published comparative genomic hybridization studies. Cancer Genet Cytogenet 135:63-90.
50. Szymas J, Schluens K, Liebert W, Petersen I. 2002. Genomic instability in pituitary adenomas. Pituitary 5:211-219.
51. Takeuchi S, Koeffler HP, Hinton DR, Miyoshi I, Melmed S, Shimon I. 1998. Mutation and expression analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in pituitary tumors. J Endocrinol 157:337-341.
52. Tahaka C, Kimura T, Yang P, Moritani M, Yamaoka T, Yamada S, Sano T, Yoshimoto K, Itakura M. 1998. Analysis of loss of heterozygosity on chromosome 11 and infrequent in activation of the MEN1 gene in sporadic pituitary adenomas. J Clin Endocrinol Metab 83:2631-2634.
53. Trautmann K, Thakker RV, Ellison DW, Ibrahim A, Lees PD, Harding B, Fischer C, Popp S, Bartram CR, Jauch A. 2001. Chromosomal aberrations in sporadic pituitary tumors. Int J Cancer 91:809-814.
54. Weil RJ, Vortmeyer AO, Huang S, Boni R, Lubensky IA, Pack S, Marx SJ, Zhuang Z, Oldfield EH. 1998. 11q13 Allelic loss in pituitary tumors in patients with multiple endocrine neoplasia syndrome type 1. Clin Cancer Res 4:1673-1678.
55. Weinstein LS, Shenker A. 1993. G protein mutations in human disease. Clin Biochem 26:333-338.
56. Weinstein LS, Shenker A, Gejman PV, Merino MJ, Friedman E, Spiegel AM. 1991. Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. N Engl J Med 325:1688-1695.
57. Wrocklage C, Gold H, Hackl W, Buchfelder M, Fahlbusch R, Paulus W. 2002. Increased menin expression in sporadic pituitary adenomas. Clin Endocrinol (Oxf) 56:589-594.
58. Yu R, Heaney AP, Lu W, Chen J, Melmed S. 2000. Pituitary tumor transforming gene causes aneuploidy and p53-dependent and p53-independent apoptosis. J Biol Chem 275:36502-36505.
59. Yu R, Lu W, Chen J, McCabe CJ, Melmed S. 2003. Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells. Endocrinology 144:4991-4998.
60. Zhang X, Horwitz GA, Prezant TR, Valentini A, Nakashima M, Bronstein MD, Melmed S. 1999a. Structure, expression, and function of human pituitary tumor-transforming gene (PTTG). Mol Endocrinol 13:156-166.
61. Zhang X, Horwitz GA, Heaney AP, Nakashima M, Prezant TR, Bronstein MD, Melmed S. 1999b. Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas. J Clin Endocrinol Metab 84:761-767.
62. Zhuang Z, Ezzat SZ, Vortmeyer AO, Weil R, Oldfield EH, Park WS, Pack S, Huang S, Agarwal SK, Guru SC, Manickam P, Debelenko LV, Rester MB, Olufemi SE, Heppner C, Crabtree JS, Burns AL, Spiegel AM, Marx SJ, Chandrasekharappa SC, Collins FS, Emmert-Buck MR, Liotta LA, Asa SL, Lubensky IA. 1997. Mutations of the MEN1 tumor suppressor gene in pituitary tumors. Cancer Res 57:5446-5451.
63. Zou H, McGarry TJ, Bernal T, Kirschner MW. 1999. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis [see comments]. Science 285:418-422.