Tumour Suppressor Genes in the Pathogenesis of Human Pituitary Tumours

Hormone Research in Paediatrics

Volumn 47, Issue 4-6, 1997, Pages 185-193

  Clayton, R N ^a   Boggild, M ^a   Bates, A S ^a   Bicknell, J ^a   Simpson, D ^a   Farrell, W ^a  

^a KEELE UNIVERSITY   (United Kingdom)

Author keywords

Pituitary tumours; Tumour suppressor genes

Indexed keywords

GENE PRODUCT; MICROSATELLITE DNA; PROTEIN P53;

ADENOHYPOPHYSIS; ALLELE; CARCINOGENESIS; CELL PROLIFERATION; CHROMOSOME 10Q; CHROMOSOME 13Q; CONFERENCE PAPER; CUSHING DISEASE; DNA POLYMORPHISM; EXON; GENE DELETION; GENE LOCUS; GENE REPRESSION; HETEROZYGOSITY LOSS; HUMAN; HYPOPHYSIS TUMOR; MEDICAL DECISION MAKING; ONCOGENE; PATHOGENESIS; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

CELL DIVISION; GENE DELETION; GENES, TUMOR SUPPRESSOR; HETEROZYGOTE; HUMANS; ONCOGENES; PITUITARY NEOPLASMS;

EID: 0030906565     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000185463     Document Type: Article

References (22)

1. Klibanski A: Editorial: Further cvidcncc for a somatic mutation theory in the pathogenesis of human pituitary tumours, J Clin Endocrinol Metah 1990;71:1415 A-1415B.
2. Herman V, Fagin J, Gonsky R, Kovacs K, Mclmcd S: Clonal origin of pituitary adenomas, J Clin Endocrinol Mctab 1990:71:1427-1433.
3. Alexander JM, Biller BMK, Bikkal H, Zervas NT, Arnold A, Klibanski A: Clinically nonfunctioning pituitary tumours arc monoclonal in origin, J Clin Invest 1990;86:336-340.
4. Levy A, Light man SL: The pathogenesis of pituitarv adenomas, Clin Endocrinol 1993:38: 559-570.
5. Jenkins JS: Current views on the pathogenesis of pituitary tumours, Endocrin Relat Cancer 1994;3:15-26.
6. Pei L, Mclmcd S, Scheithauer B, Kovacs K, Pragcr D: H-ras mutations in human pituitary carcinoma metastases, J Clin Endocrinol Me-tab 1994;78:842-846.
7. Boggild MD, Jenkinson S, Pistorcllo M, Bosca-ro M, Scanarini M, McTeman P, et al: Molecular mechanisms of pituitary tumour formation: Evidence of gcnctic heterogeneity in tumour initiation, J Clin Endocrinol Metab 1994:78: 387-392.
8. Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L: GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adcnyl cyclase in human pituitary tumours, Nature 1989:340:692-696.
9. Lyons J, Landis CA, Harsh G, et al: Two G protein oncogenes in human endocrine tumours, Science 1990;249:655-659.
10. Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodcll MA, Weinberg RA: Effects of an Rb mutation in the mouse, Nature 1992:359:295-300.
11. Larsson C, Skogscid B, Öberg K, Nakamura K, Nordenskjild M: Multiple endocrine neoplasia type 1 maps to chromosome 11 and is lost insulinoma, Nature 1988:332:85-87.
12. Bvstrom C, Larsson C, Blomberg C, Sandclin K, Falkmcr E, Skogscid B, et al: Localisation of the MEN-1 gene to a small region within chromosome Ilql3 by deletion mapping in tumours, Proc Natl Acad Sei USA 1990:87: 1968-1972.
13. Yoshimoto K, Iwahana H, Kubo K, Saito S, Itakura M: Allele loss on chromosome 11 in a pituitary tumour from a patient with multiple endocrine neoplasia type 1, Jpn J Cancer Res 1991:82:886-889.
14. Thakker RV, Pook MA, Wooding C, Boscaro M, Scanarini M, Clayton RN: Association of somatotrophinomas with loss of alleles on chromosome 11 and with gsp mutations, J Clin Invest 1993;91:2815-2821.
15. Bates AS, Buckley N, Boggild MD, Bicknell EJ, Pcrrctt CW, Broome JC, Clayton RN: Clinical and genetic changes in a ease of a Cushing’s carcinoma, Clin Endocrinol 1995:42:663-670.
16. Hardy J: Transsphenoidal microsurgical treatment of pituitary tumours; in Linfoot J (ed): Recent Advances in the Diagnosis and Treat-mentof Pituitary Tumours, New York, Raven Press, 1979, pp 375-388.
17. Fearon ER, Vogelstein B: A genetic model for colorectal tumorigenesis, Cell 1990:61:759-767.
18. Bates AS, Talbot JA, Buckley N, Bickness J, Farrell W, Clayton RN: Tumour suppressor genes as a marker of invasive behaviour in pituitary tumours, J Endocrinol 1995 (suppl): 144.
19. Bates AS, Van'l Hoff W, Jones PJ, Clayton RN: The cffect of hypopituitarism on life expectancy, J Clin Endocrin Mctab 1996:81:1169-1172.
20. Rosea T, Bcngtsson BA: Premature mortality due to cardiovascular disease in hypopituitarism, Lancet 1990:336:285-288.
21. Buckley N, Bates AS, Broome JC, Strange RC, Perrett CW, Burke CW, et al: p53 protein accumulates in Cushing's adenomas and invasive non-functional adenomas, J Clin Endocrinol Mctab 1994:79:1513-1516.
22. Levy A, Hall L, Yendall WA, I.ightman SL: P53 gene mutations in pituitary adenomas: Rare events, Clin Endocrinol 1994:41:809-814.