Genome screen in the French EGEA study: Detection of linked regions shared or not shared by allergic rhinitis and asthma

Genes and Immunity

Volumn 6, Issue 2, 2005, Pages 95-102

  Dizier, M H ^a   Bouzigon, E ^b   Guilloud Bataille, M ^a   Betard C ^c   Bousquet, J ^d   Charpin, D ^e   Gormand, F ^f   Hochez, J ^b   Just, J ^g   Lemainque, A ^c   Le Moual, N ^b   Matran, R ^h   Neukirch, F ^b   Oryszczyn, M P ^b   Paty, E ⁱ   Pin, I ^j   Vervloet, D ^k   Kauffmann, F ^b   Lathrop, M ^c   Demenais, F ^b   Annesi Maesano, I ^b   more..

^a HÔPITAL PAUL BROUSSE   (France)

^b INSERM   (France)

^c CENTRE NATIONAL DE GÉNOTYPAGE   (France)

^d HÔPITAL ARNAUD DE VILLENEUVE   (France)

^e HÔPITAL NORD   (France)

^f CENTRE HOSPITALIER LYON SUD   (France)

^g ARMAND TROUSSEAU HOSPITAL   (France)

^h LILLE UNIVERSITY HOSPITAL   (France)

ⁱ HÔPITAL NECKER ENFANTS MALADES   (France)

^j HÔPITAL MICHALLON   (France)

^k UPRES EA 3287   (France)

more..

Author keywords

Allergic rhinitis; Asthma; Genome screen; Linkage analysis

Indexed keywords

ADULT; ALLERGIC RHINITIS; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CHROMOSOME 1P; CHROMOSOME 2Q; CHROMOSOME 3P; CHROMOSOME 9P; CHROMOSOME 9Q; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; EPIDEMIOLOGICAL DATA; FAMILY STUDY; FEMALE; FRANCE; GENETIC ANALYSIS; GENETIC LINKAGE; GENETIC SCREENING; HEREDITY; HUMAN; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; MAXIMUM LIKELIHOOD METHOD; PHENOTYPE; PRIORITY JOURNAL; QUESTIONNAIRE; SIBLING; SYMPTOM;

ASTHMA; CHROMOSOMES, HUMAN; FRANCE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GENOME, HUMAN; HUMANS; LINKAGE (GENETICS); PHENOTYPE; RHINITIS;

EID: 20144388166     PISSN: 14664879     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gene.6364163     Document Type: Article

References (41)

1. Bousquet J, Van Cauwenberge P, Khaltaev N. Rhinitis and its impact on asthma. J Allergy Clin Immunol 2001; 108 (5 Suppl): S147-S334.
2. Dold S, Wjst M, von Mutius E, Reitmeir P, Stiepel E. Genetic risk for asthma, rhinitis, and atopic dermatitis. Arch Dis Child 1992; 67: 1018-1022.
3. Rasanen M, Laitinen T, Kaprio J, Koskenvuo M, Laitinen LA. Hay fever - a Finnish nationwide study of adolescent twins and their parents. Allergy 1998; 53: 885-890.
4. Annesi-Maesano I, Cotichini R, Stazi MA. Early gene-environment interaction into asthma and rhinitis comorbidity. Chest 2001; 120: 1755.
5. Hopper JL, Hannah MC, Macaskill GT, Mathews JD. Twin concordance for a binary trait: III. A bivariate analysis of hay fever and asthma. Genet Epidemiol 1990; 7: 277-289.
6. Duffy DL, Martin NG, Battistutta D, Hopper JL, Mathews JD. Genetics of asthma and hay fever in Australian twins. Am Rev Respir Dis 1990; 142 (Part 1): 1351-1358.
7. Wills-Karp M, Ewart SL. Time to draw breath: asthma-suceptibility genes are identified. Nat Genet 2004; 5: 376-387.
8. Van Eerdewegh P, Little RD, Dupuis J et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 2002; 418: 426-430.
9. Zhang Y, Leaves NI, Anderson GG et al. Positional cloning of a quantitative trait locus on chromosome l3q14 that influences immunoglobulin E levels and asthma. Nat Genet 2003; 34: 181-186.
10. Allen M, Heinzmann A, Noguchi E et al. Positional cloning of a novel gene influencing asthma from chromosome 2q14. Nat Genet 2003; 35: 258-263.
11. Laitinen T, Polvi A, Rydman P et al. Characterization of a common susceptibility locus for asthma-related traits. Science 2004; 304: 300-304.
12. Haagerup A, Bjerke T, Schoitz PO, Binderup HG, Dahl R, Kruse TA. Rhinitis - a total genome-scan for susceptibility genes suggests a locus on chromosome 4q24-q27. Eur J Hum Genet 2001; 9: 945-952.
13. Yokouchi Y, Scibasaki M, Noguchi E et al. A genome-wide linkage analysis of orchard grass-sensitive childhood seasonal rhinitis in Japanese families. Genes Immun 2002; 3: 9-13.
14. Ober C, Tsalenko A, Parry R, Cox NJ. A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. Am J Hum Genet 2000; 67: 1154-1162.
15. Dizier MH, Besse-Schmittler C, Guilloud-Bataille M et al. Genome screen for asthma and related phenotypes in the French EGEA study. Am J Respir Crit Care Med 2000; 162: 1812-1818.
16. Bouzigon E, Dizier MH, Krähenbühl C et al. Clustering patterns of LOD scores for asthma-related phenotypes revealed by a genome-wide screen in 295 French EGEA families. Hum Mol Genet 2004; 13: 3103-3113.
17. Annesi-Maesano I, Didier A, Klossek M, Chanal I, Moreau D, Bousquet J. The score for rhinitis (SFAR): a simple and valid assessment method in population studies. Allergy 2002; 57: 107-114.
18. Abel L, Alcais A, Mallet A. Comparison of four sib-pair linkage methods for analyzing sibships with more than two affecteds: interest of the binomial maximum likelihood approach. Genet Epidemiol 1998; 15: 371-390.
19. Annesi-Maesano I. Rhinitis and asthma: epidemiological evidence. Allergy Clin Immunol Intern 2001; 13: 1-7.
20. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 1995; 11: 241-247.
21. Sawcer S, Jones HB, Judge D et al. Empirical genomewide significance levels established by whole genome simulations. Genet Epidemiol 1997; 14: 223-229.
22. The Collaborative Study on the Genetics of Asthma (CSGA). A genome-wide search for asthma susceptibility loci in ethnically diverse populations. Nat Genet 1997; 15: 389-392.
23. Hizawa N, Freidhoff LR, Chin YF et al. Genetic regulation of Dermatophagoides pteronyssinus-specific IgE responsiveness: a genome-wide multipoint linkage analysis in families recruited through 2 asthmatic sibs. J Allergy Clin Immunol 1998; 102: 436-442.
24. Mathias RA, Freidhoff LR, Blumenthal MN et al. Genome-wide linkage analyses of total serum IgE using variance components analysis in asthmatic families. Genet Epidemiol 2001; 20: 340-355.
25. Koppelman GH, Stine OC, Xu J et al. Genome-wide search for atopy susceptibility genes in Dutch families with asthma. J Allergy Clin Immunol 2002; 109: 498-506.
26. Wjst M, Fischer G, Immervoll T et al. A genome-wide search for linkage to asthma. German Asthma Genetics Group. Genomics 1999; 58: 1-8.
27. Howard TD, Postma DS, Hawkins GA et al. Fine mapping of an IgE-controlling gene on chromosome 2q: analysis of CTLA4 and CD28. J Allergy Clin Immunol 2002; 110: 743-751.
28. Hizawa N, Yamaguchi E, Jinushi E et al. Increased total serum IgE levels in patients with asthma and promoter polymorphisms at CTLA4 and FCER1B. J Allergy Clin Immunol 2001; 108: 74-79.
29. Bradley M, Söderhäll C, Luthman H et al. Susceptibility loci for atopic dermatitis on chromosomes 3, 13, 15, 17 and 18 in a Swedish population. Hum Mol Genet 2002; 11: 1539-1548.
30. Ober C, Cox NJ, Abney M et al. Genome-wide search for asthma susceptibility loci in a founder population. Hum Mol Genet 1998; 7: 1393-1398.
31. Blumenthal MN, Ober C, Beaty TH et al. Genome scan for loci linked to mite sensitivity: the Collaborative study on the genetics of asthma (CSGA). Genes Immun 2004; 5: 226-231.
32. Ober C, Tsalenko A, Willadsen S et al. Genome-wide screen for atopy susceptibility alleles in the Hutterites. Clin Exp Allergy 1999; 29: S11-S15.
33. Leynaert B, Neukirch C, Kony S et al. Association between asthma and rhinitis according to atopic sensitization in a population-based study. J Allergy Clin Immunol 2004; 113: 86-93.
34. Kauffmann F, Dizier MH, Annesi-Maesano I et al. EGEA (Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy) - descriptive characteristics. Clin Exp Allergy 1999; 29 (Suppl 4): 17-21.
35. Kauffmann F, Annesi-Maesano I, Liard R et al. Construction et validation d'un questionnaire en épidémiologie respiratoire. L'exemple du questionnaire de l'étude épidémiologique des facteurs génétiques et environnementaux de l'asthme, l'hyperréactivité bronchique et de l'atopie (EGEA). Rev Mal Resp 2002; 19: 323-333.
36. O'Connell J, Weeks E. PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 1998; 63: 259-266.
37. Satsangi J, Parkes M, Louis E et al. Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. Nat Genet 1996; 14: 199-202.
38. Majumder PP, Pal N. Nonrandom segregation: uniformly most powerful test and related considerations. Genet Epidemiol 1987; 4: 277-287.
39. Alcais A, Philippi A, Abel L. Genetic model-free linkage analysis using the maximum-likelihood-binomial method for categorical traits. Genet Epidemiol 1999; 17 (Suppl 1): S467-S472.
40. Abel L, Muller-Myhsok B. Robustness and power of the maximum-likelihood-binomial and maximum-likelihoodscore methods, in multipoint linkage analysis of affectedsibship data. Am J Hum Genet 1998; 63: 638-647.
41. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 1996; 58: 1347-1363.