Ocular safety of INS365 ophthalmic solution: A P2Y2 agonist in healthy subjects

Journal of Ocular Pharmacology and Therapeutics

Volumn 17, Issue 2, 2001, Pages 173-179

  Mundasad, M V ^a,b   Novack, G D ^c   Allgood, V E ^d   Evans, R M ^d   Gorden, J C ^d   Yerxa, B R ^d  

^a BRISTOL EYE HOSPITAL   (United Kingdom)

^b SIMBEC RESEARCH LTD   (United Kingdom)

^c Pharma Logic Development Inc   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIQUAFOSOL; P1,P4 DI(5' URIDINE)TETRAPHOSPHATE; PURINE P2Y RECEPTOR; PURINERGIC RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLEPHAROSPASM; CLINICAL TRIAL; CONJUNCTIVITIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG FORMULATION; DRUG MECHANISM; DRUG SAFETY; DRUG TOLERABILITY; DYSESTHESIA; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPESTHESIA; LACRIMATION; MALE; NORMAL HUMAN; OPHTHALMOLOGY; PAIN; PARESTHESIA; RANDOMIZED CONTROLLED TRIAL; VISUAL IMPAIRMENT; XEROPHTHALMIA;

EID: 0035045318     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/10807680151125519     Document Type: Article

References (12)

1. Regulation of transepithelial ion transport and intracellular calcium by extracellular ATP in human normal and cystic fibrosis airway epithelium
2. Activation by extracellular nucleotides of chloride secretion in the airway epithelia of patients with cystic fibrosis
3. Effect of extracellular ATP and UTP on fluid transport by human nasal epithelial cells in culture
4. Altered fluid transport across airway epithelium in cystic fibrosis
5. Acute safety and effects on mucociliary clearance of aerosolized uridine 5′triphosphate ± amiloride in normal human adults
6. Effect of uridine 5′-triphosphate plus amiloride on mucociliary clearance in adult cystic fibrosis
7. Evidence that UTP and ATP regulate phospholipase C through a common extracellular 5′-nucleotide receptor in human airway epithelial cells
8. Nucleotide regulation of goblet cells in human airway epithelial explants: Normal exocytosis in cystic fibrosis
9. Pharmacological modulation of fluid secretion in the pigmented rabbit conjunctiva
10. Regulation of ocular mucin secretion by P2Y2 nucleotide receptors in rabbit and human conjunctiva
11. INS365, a P2Y2 receptor agonist increases Schirmer scores in albino rabbits
12. 2 receptor gene expression in primate ocular tissues by nonisotopic in situ hybridization