Synthesis and in vitro and in vivo structure-activity relationships of novel antifungal triazoles for dermatology

Journal of Medicinal Chemistry

Volumn 48, Issue 6, 2005, Pages 2184-2193

  Meerpoel, Lieven ^a   Backx, Leo J J ^a   Van Der Veken, Louis J E ^a   Heeres, Jan ^b   Corens, David ^a   De Grout, Alex ^a   Odds, Frank C ^c   Van Gerven, Frans ^a   Woestenborghs, Filip A A ^a   Van Breda, Andre ^a   Oris, Michel ^a   Van Dorsselaer, Pascal ^a   Willemsens, Gustaaf H M ^a   Vermuyten, Karen J P ^a   Marichal, Patrick J M G ^a   Vanden Bossche, Hugo F ^a   Ausma, Jannie ^d   Borgers, Marcel ^d  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b JANSSEN RESEARCH FOUNDATION   (Belgium)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

^d Barrier Therapeutics NV   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

1 [4 [4 [4 [[4 (2,4 DIFLUOROPHENYL) 4 (1H 1,2,4 TRIAZOL 1 YLMETHYL) 1,3 DIOXOLAN 4 YL]METHOXY]PHENYL] 1 PIPERAZINYL]PHENYL] 3 (1 METHYLETHYL) 2 IMIDAZOLIDINONE; 1 ETHYL 3 [4 [4 [4 [[4 (2,4 DIFLUOROPHENYL) 4 (1H 1,2,4 TRIAZOL 1 YLMETHYL) 1,3 DIOXOLAN 2 YL]METHOXY]PHENYL] 1 PIPERAZINYL]PHENYL] 5 PROPYL 1,3,5 TRIAZINE 2,4,6(1H,3H,5H) TRIONE; 1 ETHYL 3 [4 [4 [4 [[4 (2,4 DIFLUOROPHENYL) 4 (1H 1,2,4 TRIAZOL 1 YLMETHYL) 1,3 DIOXOLAN 4 YL]METHOXY]PHENYL] 1 PIPERAZINYL]PHENYL] 5 PROPYL 1,3,5 TRIAZINE 2,4,6(1H,3H,5H) TRIONE; 1 ETHYL 3 [4 [4 [4 [[4 (2,4 DIFLUROROPHENYL) 4 (1H 1,2,4 TRIAZOL 1 YLMETHYL) 1,3 DIOXOLAN 2 YL]METHOXY]PHENYL] 1 PIPERAZINYL]PHENYL] 5,5 DIMETHYL 2,4,6 (1H,3H,5H) PYRIMIDINETRIONE; 1 ETHYL 3 [4 [4 [4 [[4 (2,4 DIFLUROROPHENYL) 4 (1H 1,2,4 TRIAZOL 1 YLMETHYL) 1,3 DIOXOLAN 4 YL]METHOXY]PHENYL] 1 PIPERAZINYL]PHENYL] 5,5 DIMETHYL 2,4,6(1H,3H,5H) PYRIMIDINETRIONE; ANTIFUNGAL AGENT; ITRACONAZOLE; TERBINAFINE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA; CONTROLLED STUDY; DERMATOLOGY; DERMATOMYCOSIS; DERMATOPHYTE; DRUG ACTIVITY; DRUG DOSE REGIMEN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FUNGUS ISOLATION; GUINEA PIG; IN VITRO STUDY; IN VIVO STUDY; MICROSPORUM CANIS; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TRICHOPHYTON MENTAGROPHYTES;

ANIMALS; ANTIFUNGAL AGENTS; DERMATOLOGIC AGENTS; GUINEA PIGS; IMIDAZOLES; ITRACONAZOLE; MICE; MITOSPORIC FUNGI; MYCOSES; NAPHTHALENES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 20144379891     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0494772     Document Type: Article

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