The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 9, 2004, Pages 3272-3278

  Bossche, Hugo Vanden ^a,e   Ausma, Jannie ^b,d   Bohets, Hilde ^a   Vermuyten, Karen ^a   Willemsens, Gustaaf ^a   Marichal, Patrick ^a   Meerpoel, Lieven ^a   Odds, Frank ^c   Borgers, Marcel ^b  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b Barrier Therapeutics   (Belgium)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

^d Barrier Therapeutics NV   (Belgium)

^e NONE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

1 [4 [4 [4 [[4 (2,4 DIFLUOROPHENYL) 4 (1H 1,2,4 TRIAZOL 1 YLMETHYL) 1,3 DIOXOLAN 2 YL]METHOXY]PHENYL]PIPERAZIN 1 YL]PHENYL] 3 (1 METHYLETHYL) 2 IMIDAZOLIDINONE; 14ALPHA METHYLSTEROL; AROMATASE; CALCIFEDIOL; CHOLESTEROL; CYCLOSPORIN; CYTOCHROME P450; CYTOCHROME P450 11A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2C10; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; EBUCIROL; ERGOSTEROL; ITRACONAZOLE; LANOSTEROL; MIDAZOLAM; PYRROLE DERIVATIVE; R 126683; RETINOIC ACID; STEROID 11BETA MONOOXYGENASE; STEROID 17,20 LYASE; STEROID 17ALPHA MONOOXYGENASE; STEROL 14ALPHA DEMETHYLASE; STEROL DERIVATIVE; TESTOSTERONE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DERMATOPHYTE; DRUG ACTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; HEPATOMA CELL; HUMAN; HUMAN CELL; HYDROXYLATION; IC 50; IN VITRO STUDY; IN VIVO STUDY; MICROSPORUM CANIS; MINIMUM INHIBITORY CONCENTRATION; MYCOSIS; PRIORITY JOURNAL; STEROL METABOLISM; STEROL SYNTHESIS; TRICHOPHYTON; TRICHOPHYTON MENTAGROPHYTES; TRICHOPHYTON RUBRUM; VITAMIN D METABOLISM; YEAST;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; ADRENAL CORTEX; ANDROGENS; ANIMALS; ANTIFUNGAL AGENTS; CANDIDA ALBICANS; CATTLE; CELLS, CULTURED; CHOLESTEROL; CYTOCHROME P-450 ENZYME SYSTEM; EPIDERMIS; ERGOSTEROL; ESTROGENS; HUMANS; IMIDAZOLES; ITRACONAZOLE; KIDNEY; MALE; MICROSOMES; MICROSOMES, LIVER; MICROSPORUM; MITOCHONDRIA; PHARMACEUTICAL PREPARATIONS; PLACENTA; RATS; RATS, WISTAR; STEROID 11-BETA-HYDROXYLASE; TESTIS; TRETINOIN; TRIAZOLES; TRICHOPHYTON;

EID: 4344704026     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.9.3272-3278.2004     Document Type: Article

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