Total synthesis of (2R,4S,2′S,3′R)-hydroxyitraconazole: Implementations of a recycle protocol and a mild and safe phase-transfer reagent for preparation of the key chiral units

Tetrahedron Asymmetry

Volumn 14, Issue 22, 2003, Pages 3487-3493

  Tanoury, Gerald J ^a,b   Hett, Robert ^a   Wilkinson, H Scott ^a   Wald, Stephen A ^a   Senanayake, Chris H ^a,c  

^a SUNOVION PHARMACEUTICALS INC   (United States)

^b VERTEX PHARMACEUTICALS   (United States)

^c BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 DIOXOLANE DERIVATIVE; 2 (2,4 DICHLOROPHENYL) 2 (1H 1,2,4 TRIAZOL 1 YLMETHYL) 4 TOSYLOXYMETHYL 1,3 DIOXOLANE TOSYLATE; 2,4 DIHYDRO 4 BROMOPHENYL 2 (3 HYDROXY 2 BUTYL) 3H 1,2,4 TRIAZOL 3 ONE; 2,4 DIHYDRO 4 BROMOPHENYL 3H 1,2,4 TRIAZOL 3 ONE; 4 [4 [4 [4 [[2 (2,4 DICHLOROPHENYL) 2 (1H 1,2,4 TRIAZOL 1 YLMETHYL) 1,3 DIOXOLAN 4 YL]METHOXY]PHENYL] 1 PIPERAZINYL]PHENYL] 2,4 DIHYDRO 2 (3 HYDROXY 2 BUTYL) 3H 1,2,4 TRIAZOL 3 ONE HYDROXYITRACONAZOLE; 4,5 DIMETHYL 1,2,3 DIOXATHIOLANE 2,2 DIOXIDE; ACETONITRILE; ANTIFUNGAL AGENT; HYDROXYITRACONAZOLE; ITRACONAZOLE; POTASSIUM CARBONATE; SULFATE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CHEMICAL REACTION KINETICS; CHIRALITY; CRYSTALLIZATION; DIASTEREOISOMER; DRUG SYNTHESIS; ENANTIOMER; PHASE TRANSITION; PRIORITY JOURNAL;

EID: 0242710844     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetasy.2003.01.001     Document Type: Article

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