The nicorandil-induced vasodilation in humans is inhibited by miconazole

Journal of Cardiovascular Pharmacology

Volumn 45, Issue 4, 2005, Pages 290-294

  Ueda, Keiko ^a   Goto, Chikara ^a   Jitsuiki, Daisuke ^a   Umemura, Takashi ^a   Nishioka, Kenji ^a   Kimura, Masashi ^a   Noma, Kensuke ^a   Nakagawa, Keigo ^a   Oshima, Tetsuya ^a   Yoshizumi, Masao ^a   Chayama, Kazuaki ^a   Higashi, Yukihito ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

ATP sensitive potassium channels; Endothelium derived hyperpolarizing factor; Nicorandil; Nitric oxide

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CYTOCHROME P450; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; GLIBENCLAMIDE; INDOMETACIN; MICONAZOLE; N(G) METHYLARGININE; NICORANDIL; NITRIC OXIDE; POTASSIUM CHANNEL; PROSTAGLANDIN; VASODILATOR AGENT;

ADULT; ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; FOREARM BLOOD FLOW; HUMAN; HUMAN EXPERIMENT; INFUSION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; STRAIN GAUGE PLETHYSMOGRAPH; STRAIN GAUGE TRANSDUCER; VASODILATATION;

ADULT; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MALE; MICONAZOLE; NICORANDIL; VASODILATION;

EID: 20144371841     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.fjc.0000155382.06799.20     Document Type: Article

References (35)

1. Taira N. Nicorandil as a hybrid between nitrates and potassium channel activators. Am J Cardiol. 1989;63:18J-24J.
2. + channel opener nicorandil. Eur Heart J. 2003;24:1296-1303.
3. The IONA Study Group. Effect of nicorandil on coronary events in patients with stable angina: the Impact Of Nicorandil in Angina (IONA) randomized trial. Lancet. 2002;359:1269-1275.
4. Matsubara T, Minatoguchi S, Matsuo H, et al. Three minute, but not one minute, ischemia and nicorandil have a preconditioning effect in patients with coronary artery disease. J Am Coll Cardiol. 2000;35:345-351.
5. Patel DJ, Purcell HJ, Fox KM. Cardioprotection by opening of the KATP channel in unstable angina: Is this a clinical manifestation of myocardial preconditioning? Results of a randomized study with nicorandil. Eur Heart J. 1999;20:51-57.
6. Nelson MT, Quayle JM. Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol. 1995;268:C799-C822.
7. Fletou M, Vanhoutte PM. Endothelium-dependent hyperpolarization of canine smooth muscle. Br J Pharmacol. 1988;93:515-524.
8. Chen G, Suzuki H, Weston AH. Acetylcholine release encothelium-derived hyperpolarizing factor and EDRF from blood vessels. Br J Pharmacol. 1988;98:1165-1174.
9. Campbell WB, Gebremedhin D, Pratt PF. Identification of epoxycicosa-trienoic acids as endothelium-derived hyperpolarizing factors. Circ Res. 1996;78:415-423.
10. Fisslthaler B, Popp R, Kiss L, et al. Cytochrome P450 2C is an EDHF synthase in coronary arteries. Nature. 1999;401:493-497.
11. + is an encothelium-derived hyperpolarizing factor in rat arteries. Nature. 1998;396:269-272.
12. Chaytor AT, Evans WH, Griffith TM. Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries. J Physiol. 1998;508:561-573.
13. Taylor HT, Chaytor AT. Evans WH, et al. Inhibition of the gap junctional component of endothelium-dependent relaxations in rabbit iliac artery by 18-alpha glycyrrhetinic acid. Br J Pharmacol. 1998;125:1-3.
14. Matoba T, Shimokawa H, Nakashima M, et al. Hydrogen peroxide is an endotheoium-derived hyperpolarizing factor in mice. J Clin Invest. 2000;106:1521-1530.
15. Matoba T, Shimokawa H, Nakashima M, et al. Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in human mesenteric arteries. Biochem Biophys Res Commun. 2002;290:909-913.
16. Murphy ME, Brayden JE. Nitric oxide hyperpolarizes rabbit mesenteric arteries via ATP-sensitive potassium channels. J Physiol. 1995;486:47-58.
17. Jackson WF, Konig A, Dambacher T, et al. Prostacyclin-induced vasodilation in rabbit heart is mediated by ATP-sensitive potassium channels. Am J Physiol. 1993;264:H238-H243.
18. Cohen RA, Vanhoutte PM. Endothelium-dependent hyperpolarization: beyond nitric oxide and cyclic GMP. Circulation. 1995;92:3337-3349.
19. + channel. Am J Physiol. 1998;275:C848-C856.
20. Champion HC, Kadowitz PJ. Vasodilator response to acethlcholine, bradykinin and substance P arc mediated by a TEA-sensitive mechanism. Am J Physiol. 1997;273:R414-R422.
21. + channels in arterial smooth muscle. Science. 1989;245:177-180.
22. Ohnishi Y, Hirano K, Nishimura J, et al. Inhibitory effects of brefeldin A, a membrane transport blocker, on the bradykinin-induced hyperpolarization- mediated relaxation in the porcine coronary artery. Br J Pharmacol. 2001;134:168-178.
23. Higashi Y, Sasaki S, Kurisu S. et al. Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects-role of encothelium-derived nitric oxide. Circulation. 1999;100:1194-1202.
24. Higashi Y, Sasaki S, Nakagawa K, et al. Endothelial function and oxidative stress in renovascular hypertension. N Engl J Med. 2002;346:1954-1962.
25. + channels does not affect reactive hyperemia in human forearm. Am J Physiol. 2003;284:H711-H718.
26. Bank AJ, Sih R, Mullen K, et al. Vascular ATP-dependent potassium channels, nitric oxide, and human forearm reactive hyperemia. Cardiovasc Drugs Ther. 2000;14:23-29.
27. Coppack SW, Lant AF, McIntosh CS, et al. Pharmacokinetic and pharmacodynamic studies of glibenclamide in non-insulin dependent diabetes mellitus. Br J Clin Pharmacol. 1990;29:673-684.
28. Bijlstra PJ, Lutterman JA, Russel FGM, et al. Interaction of sulphonylurea derivatives with vascular ATP-sensitive potassium channels in humans. Diabetologia. 1996;39:1083-1090.
29. Busses R, Edwards G, Feletou M. EDHF: bringing the concepts together. Trends Pharmacol Sci. 2002;24:374-380.
30. Feletou M, Vanhoutte PM. The alternative: EDHF. J Mol Cell Cardiol. 1999;31:15-22.
31. Hecker M, Bara AT, Bauersachs J. Characterization of endothelium-derived hyperpolarizing factor as a cytochrome P450-derived arachidonic acid metabolite in mammals. J Physiol. 1994;481:407-414.
32. Popp R. A transferable, β-naphthoflavone-inducible, hyperpolarizing factor is synthesized by native and cultured porcine coronary endothelial cells. J Physiol. 1996;497:699-709.
33. Widmann MD, Weintraub NL, Fudge JL. Cytochrome P-450 pathway in acetylcholine-induced canine coronary microvascular vasodilation in vivo. Am J Physiol. 1998;274:H283-H289.
34. Quilley J. Is EDHF an epoxyeicosatrienoic acid? Trends Pharmacol Sci. 2000;21:121-124.
35. Fleming I. Cytochrome P-450 enzymes in vascular homeostasis. Circ Rex. 2001;89:753-762.