Contribution of de novo point mutations to the overall mutational burden in mitochondrial DNA of adult rats

Experimental Gerontology

Volumn 40, Issue 5, 2005, Pages 396-402

  Khaidakov, M ^a   Chavannes Turesky, N ^a   Cooney, C A ^a   Dupont Versteegden, E E ^a   Kennedy, R H ^a   Siegel, E R ^a   Khaidakova, G ^a   Shmookler Reis, R J ^a  

^a CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

Author keywords

Aging; Brain; Mitochondrial DNA; Muscle; Point mutations; Rats

Indexed keywords

MITOCHONDRIAL DNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CHI SQUARE DISTRIBUTION; DENATURING GRADIENT GEL ELECTROPHORESIS; GENE AMPLIFICATION; GENE SEQUENCE; GENETIC CODE; GERM LINE; MALE; MITOCHONDRION; MOLECULAR BIOLOGY; MOLECULAR CLONING; MUSCLE TISSUE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; SEQUENCE ANALYSIS; STATISTICAL SIGNIFICANCE;

AGING; ANIMALS; CEREBRAL CORTEX; DNA MUTATIONAL ANALYSIS; DNA TRANSPOSABLE ELEMENTS; DNA, MITOCHONDRIAL; ELECTROPHORESIS; MALE; MUSCLE, SKELETAL; PLASMIDS; POINT MUTATION; RATS; RATS, INBRED F344;

ANIMALIA;

EID: 20144370047     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2005.02.007     Document Type: Article

References (31)

1. R. Castellani, K. Hirai, G. Aliev, K.L. Drew, A. Nunomura, A. Takeda, A.D. Cash, M.E. Obrenovich, G. Perry, and M.A. Smith Role of mitochondrial dysfunction in Alzheimer's disease J. Neurosci. Res. 70 2002 357 360
2. H.A. Coller, N.D. Bodyak, and K. Khrapko Frequent intracellular clonal expansions of somatic mtDNA mutations: significance and mechanisms Ann. N.Y. Acad. Sci. 959 2002 434 447
3. P. Corbisier, and J. Remacle Involvement of mitochondria in cell degeneration Eur. J. Cell Biol. 51 1990 173 182
4. G.A. Cortopassi, and A. Wong Mitochondria in organismal aging and degeneration Biochim. Biophys. Acta 1410 1999 183 193
5. D.L. Croteau, R.H. Stierum, and V.A. Bohr Mitochondrial DNA repair pathways Mutat. Res. 434 1999 137 148
6. J.L. Elson, D.C. Samuels, D.M. Turnbull, and P.F. Chinnery Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age Am. J. Hum. Genet. 68 2001 802 806
7. A.G. Fantel, and R.E. Person Involvement of mitochondria and other free radical sources in normal and abnormal fetal development Ann. N.Y. Acad. Sci. 959 2002 424 433
8. G. Fayet, M. Jansson, D. Sternberg, A.R. Moslemi, P. Blondy, A. Lombes, M. Fardeau, and A. Oldfors Ageing muscle: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function Neuromuscul. Disord. 12 2002 484 493
9. M.L. Ferrandiz, M. Martinez, E. De Juan, A. Diez, G. Bustos, and J. Miquel Impairment of mitochondrial oxidative phosphorylation in the brain of aged mice Brain Res. 644 1994 335 338
10. D. Harman Free radical theory of ageing: dietary implications Am. J. Clin. Nutr. 25 1972 839 843
11. M. Khaidakov, R.H. Heflich, M.G. Manjanatha, M.B. Myers, and A. Aidoo Accumulation of point mutations in mitochondrial DNA of aging mice Mutat. Res. 526 2003 1 7
12. Klein, C.B., 2004. Dietary Antioxidants: Prevention of Deletion Mutations (Personal communication).
13. S.A. Kovalenko, G. Kopsidas, J. Kelso, F. Rosenfeldt, and A.W. Linnane Tissue-specific distribution of multiple mitochondrial DNA rearrangements during human aging Ann. N.Y. Acad. Sci. 854 1998 171 181
14. M.T. Lin, D.K. Simon, C.H. Ahn, L.M. Kim, and M.F. Beal High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain Hum. Mol. Genet. 11 2002 133 145
15. B. Mackler, R. Grace, B. Haynes, G.J. Bargman, and T.H. Shepard Studies of mitochondrial energy systems during embryogenesis in the rat Arch. Biochem. Biophys. 158 1973 662 668
16. P. Mecocci, U. MacGarvey, A.E. Kaufman, D. Koontz, J.M. Shoffner, D.C. Wallace, and M.F. Beal Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain Ann. Neurol. 34 1993 609 616
17. J. Miquel, A.C. Economos, J. Fleming, and J.E. Johnson Jr. Mitochondrial role in cell aging Exp. Gerontol. 15 1980 575 591
18. C. Munscher, J. Muller-Hocker, and B. Kadenbach Human aging is associated with various point mutations in tRNA genes of mitochondrial DNA Biol. Chem. Hoppe Seyler 374 1993 1099 1104
19. E. Nekhaeva, N.D. Bodyak, Y. Kraytsberg, S.B. McGrath, N.J. Van Orsouw, A. Pluzhnikov, J.Y. Wei, J. Vijg, and K. Khrapko Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues Proc. Natl Acad. Sci. USA 99 2002 5521 5526
20. W.C. Orr, R.J. Mockett, J.J. Benes, and R.S. Sohal Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity in Drosophila melanogaster J. Biol. Chem. 278 2003 26418 26422
21. F. Pallotti, X. Chen, E. Bonilla, and E.A. Schon Evidence that specific mtDNA point mutations may not accumulate in skeletal muscle during normal human aging Am. J. Hum. Genet. 59 1996 591 602
22. C. Richter, J.W. Park, and B.N. Ames Normal oxidative damage to mitochondrial and nuclear DNA is extensive Proc. Natl Acad. Sci. USA 85 1988 6465 6467
23. T.H. Shepard, L.A. Muffley, and L.T. Smith Ultrastructural study of mitochondria and their cristae in embryonic rats and primate (N. memestrina) Anat. Rec. 252 1998 383 392
24. T.B. Sherer, R. Betarbet, and J.T. Greenamyre Environment, mitochondria, and Parkinson's disease Neuroscientist 8 2002 192 197
25. D.K. Simon, M.T. Lin, L. Zheng, G.J. Liu, C.H. Ahn, L.M. Kim, W.M. Mauck, F. Twu, M.F. Beal, and D.R. Johns Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease Neurobiol. Aging 25 2004 71 81
26. C.C. Spencer, C.E. Howell, A.R. Wright, and D.E. Promislow Testing an 'aging gene' in long-lived Drosophila strains: increased longevity depends on sex and genetic background Aging Cell 2 2003 123 130
27. T. Tanimura, and T.H. Shepard Glucose metabolism by rat embryos in vitro Proc. Soc. Exp. Biol. Med. 135 1970 51 54
28. A. Terman, H. Dalen, J.W. Eaton, J. Neuzil, and U.T. Brunk Aging of cardiac myocytes in culture: oxidative stress, lipofuscin accumulation, and mitochondrial turnover Ann. N.Y. Acad. Sci. 1019 2004 70 77
29. R.K. Vinson, and B.F. Hales DNA repair during organogenesis Mutat. Res. 509 2002 79 91
30. Wallace, D.C., Lott, M.T., 2004. 'MITOMAP: A Human Mitochondrial Genome Database' (http://www.mitomap.org).
31. T.J. Wetter, A.C. Gazdag, D.J. Deanm, and G.D. Cartee Effect of calorie restriction on in vivo glucose metabolism by individual tissues in rats Am. J. Physiol. 276 1999 E728 E738