Dynamics of cytomegalovirus (CMV)-specific T cells in HIV-1-infected individuals progressing to AIDS with CMV end-organ disease

Journal of Infectious Diseases

Volumn 191, Issue 6, 2005, Pages 873-880

  Bronke, Corine ^a   Palmer, Nanette M ^a   Jansen, Christine A ^a   Westerlaken, Geertje H A ^a,b   Polstra, Abeltje M ^a   Reiss, Peter ^a   Bakker, Margreet ^a   Miedema, Frank ^a,b   Tesselaar, Kiki ^a,b   Van Baarle, Debbie ^a,b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; GRANZYME B; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PERFORIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CELL COUNT; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DISEASE COURSE; ENZYME ASSAY; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LONGITUDINAL STUDY; LYMPHOCYTE COUNT; MALE; MULTIPLE ORGAN FAILURE; ONSET AGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS LOAD;

ADULT; AIDS-RELATED OPPORTUNISTIC INFECTIONS; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; COHORT STUDIES; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; CYTOMEGALOVIRUS RETINITIS; DISEASE PROGRESSION; GRANZYMES; HIV INFECTIONS; HIV LONG-TERM SURVIVORS; HIV-1; HUMANS; INTERFERON TYPE II; LYMPHOCYTE COUNT; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; NETHERLANDS; PORE FORMING CYTOTOXIC PROTEINS; SERINE ENDOPEPTIDASES; VIRAL LOAD;

EID: 20044383168     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/427828     Document Type: Article

References (24)

1. Pass RF. Cytomegalovirus. Knipe DM, Howley PM, eds. Fields virology. 4th ed. Vol 2. Philadelphia: Lippincott Williams & Wilkins, 2001: 2675-705.
2. + T lymphocytes in healthy seropositive donors. J Virol 2000; 74:8140-50.
3. Dunn HS, Haney DJ, Ghanekar SA, Stepick-Biek P, Lewis DB, Maecker HT. Dynamics of CD4 and CD8 T cell responses to cytomegalovirus in healthy human donors. J Infect Dis 2002; 186:15-22.
4. Sison RF, Holland GN, MacArthur LJ, Wheeler NC, Gottlieb MS. Cytomegalovirus retinopathy as the initial manifestation of the acquired immunodeficiency syndrome. Am J Ophthalmol 1991; 112:243-9.
5. + T cells produce antiviral cytokines but are impaired in cytolytic function. J Exp Med 2000; 192:63-76.
6. + T-cell responses to CMV in HIV-1 infected subjects. Virology 2001; 279:459-70.
7. + T cell frequencies by flow cytometry: evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency. J Clin Invest 1997; 99:1739-50.
8. Schrier RD, Freeman WR, Wiley CA, McCutchan JA, the NHRC group. Immune predispostions for cytomegalovirus retinitis in AIDS. J Clin Invest 1995; 95:1741-6.
9. Torriani FJ, Freeman WR, Macdonald JC, et al. CMV retinitis recurs after stopping treatment in virological and immunological failures of potent antiretroviral therapy. AIDS 2000; 14:173-80.
10. Kalams SA, Walker BD. The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses. J Exp Med 1998; 188:2199-204.
11. + virus-specific cytotoxic T lymphocytes. J Med Virol 1994; 43:103-10.
12. Wills MR, Carmichael AJ, Mynard K, et al. The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL. J Virol 1996; 70:7569-79.
13. + T cell expansions: evidence for impaired CTL effector function. Eur J Immunol 2001; 31:677-86.
14. DiDomenico N, Link H, Knobel R, et al. COBAS AMPLICOR: fully automated RNA and DNA amplification and detection system for routine diagnostic PCR. Clin Chem 1996; 42:1915-23.
15. + T lymphocytes and increased EBV load in HIV-1 infected individuals progressing to AIDS related non-Hodgkin lymphoma. Blood 2001; 98:146-55.
16. + effector T cells in the course of HIV-1 infection: longitudinal analyses in slow and rapid progressors. Clin Immunol 2004; 113:299-309.
17. + T cell proliferation is coupled to perforin expression and is maintained in nonprogressors. Nat Immunol 2002; 3:1061-8.
18. Spiegel HML, Ogg GS, DeFalcon E, et al. Human immunodeficiency virus type 1- and cytomegalovirus-specific cytotoxic T lymphocytes can persist at high frequency for prolonged periods in the absence of circulating peripheral CD4 T cells. J Virol 2000; 74:1018-22.
19. + HIV-specific T cells during progression to AIDS. Blood 2002; 99:2505-11.
20. + T lymphocytes. J Immunol 2001; 167:181-7.
21. Kägi D, Hengartner H. Different roles for cytotoxic T cells in the control of infections with cytopathic versus noncytopathic viruses. Curr Opin Immunol 1996; 8:472-7.
22. Kaur A, Kassis N, Hale CL, et al. Direct relationship between suppression of virus-specific immunity and emergence of cytomegalovirus disease in simian AIDS. J Virol 2003; 77:5749-58.
23. Weinberg A, Wohl DA, MaWhinney S, et al. Cytomegalovirus-specific IFN-γ production is associated with protection against cytomegalovirus reactivation in HIV-infected patients on highly active antiretroviral therapy. AIDS 2003; 17:2445-50.
24. + T cells in healthy and immunosuppressed virus carriers. Blood 2001; 98:754-61.