Absence of cardiotoxicity of the experimental cytotoxic drug cyclopentenyl cytosine (CPEC) in rats

Archives of Toxicology

Volumn 79, Issue 5, 2005, Pages 268-276

  Schimmel, Kirsten ^a   Bennink, Roel ^b   De Bruin, Kora ^b   Leen, Rene ^b   Sand, Karsten ^b   Van Den Hoff, Maurice ^b   Van Kuilenburg, André ^b   Vanderheyden, Jean Luc ^c   Steinmetz, Neil ^c   Pfaffendorf, Martin ^b   Verschuur, Arnauld ^b   Guchelaar, Henk Jan ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c Theseus Imaging Corporation   (United States)

Author keywords

99mTc Annexine; Apoptosis; Cardiotoxicity; CPEC; Cyclopentenyl cytosine; Rat

Indexed keywords

1 (4,5 DIHYDROXY 3 HYDROXYMETHYL 2 CYCLOPENTEN 1 YL)CYTOSINE; ANTINEOPLASTIC AGENT; CASPASE 3; CYTOCHROME C; CYTOSINE DERIVATIVE; LIPOCORTIN 5; TECHNETIUM 99M; TROPONIN T;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CADAVER; CARDIOTOXICITY; CELL ISOLATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME DEGRADATION; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART SCINTISCANNING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; MALE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RADIATION DETECTION; RAT; SPECIES COMPARISON;

ANIMALS; ANNEXIN A5; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARDIOMYOPATHIES; CYTIDINE; DISEASE MODELS, ANIMAL; HEART; HEART ATRIA; IN SITU NICK-END LABELING; MALE; MYOCARDIAL CONTRACTION; MYOCARDIUM; ORGANOTECHNETIUM COMPOUNDS; RATS; RATS, WISTAR; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TROPONIN T;

RATTUS NORVEGICUS;

EID: 20044376125     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-004-0633-5     Document Type: Article

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