StAR and progesterone producing enzymes (3β-hydroxysteroid dehydrogenase and cholesterol side-chaine cleavage cytochromes P450) in human epithelial ovarian carcinoma: Immunohistochemical and real-time PCR studies

Cancer Science

Volumn 96, Issue 4, 2005, Pages 232-239

  Abd Elaziz, Manar ^a   Moriya, Takuya ^a   Akahira, Jun Ichi ^a   Suzuki, Takashi ^a   Sasano, Hironobu ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; CHOLESTEROL; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); KI 67 ANTIGEN; PROGESTERONE; PROGESTERONE RECEPTOR; SEX HORMONE; STEROIDOGENIC ACUTE REGULATORY PROTEIN;

ADULT; AGED; ARTICLE; CANCER SIZE; CANCER STAGING; CELL PROLIFERATION; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; OVARY CARCINOMA; PRIORITY JOURNAL; PROGESTERONE SYNTHESIS; PROGNOSIS; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; STEROIDOGENESIS;

17-HYDROXYSTEROID DEHYDROGENASES; ADULT; AGED; CARCINOMA; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; OVARIAN NEOPLASMS; PHOSPHOPROTEINS; PROGESTERONE; PROGNOSIS; RECEPTORS, PROGESTERONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 20044364176     PISSN: 13479032     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2005.00040.x     Document Type: Article

References (41)

1. Parkin MD. Cancers of the breast, endometrium and ovary: geographic correlations. European J Cancer Clin Oncology 1989; 25: 1917-25.
2. Adami AO, Bergstrom R, Person I, Sparen P. The incidence of ovarian cancer in Sweden 1960-84. Am J Epidemiol 1990; 132: 446-52.
3. Greenlee RT, Hill-Harmon MB, Murray T, Thun M. Cancer statistics, 2001. CA Cancer J Clin 2001; 51: 15-36.
4. Wang J, Li AJ, Karlan BY. Chemotherapy in epithelial ovarian cancer. Cancer Women Health Reports 2002; 2: 20-6.
5. Makar AP. Hormonal therapy in epithelial ovarian cancer. Endocrine-Related Cancer 2000; 7: 85-93.
6. Friedlander ML, Dembo AJ. Prognostic factors in ovarian cancer. Sem Oncol 1991; 18: 205-12.
7. Akahira J, Yoshikawa H, Shimizu Y, Tsunematsu R, Hirakawa T, Kuramoto H, Shiromizu K, Kuzuya K, Kamura T, Kikuchi Y, Kodama S, Yamamoto K, Sato S. Prognostic factors of stage IV epithelial ovarian cancer: a multicenter Retrospective study. Gynecologic Oncol 2001; 81: 398-403.
8. Kaufmann M, Von Minckwitz G, Kuhn W, Schmid H, Costa S, Goerttler K, Bastert G. Combination of new biologic parameters as prognostic index in epithelial ovarian carcinoma. Int J Gynecol Cancer 1995; 5: 49-55.
9. Sevelda P, Denison U, Schemper M, Spona J, Vavra N, Salzer H. Oestrogen and progesterone receptor content as a prognostic factor in advanced epithelial ovarian carcinoma. Br J Obestet Gynaecol 1990; 97: 706-12.
10. Clinton GM, Hua W. Estrogen action in human ovarian cancer. Crit Rev Oncol Hematol 1997; 25: 1-9.
11. Risch HA. Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone. J Natl Cancer Inst 1998; 90: 1774-86.
12. Emons G, Kavanagh JJ. Hormonal interactions in ovarian cancer. Hematol Oncol Clin North Am 1999; 13: 145-61.
13. Adami HO, Hsieh CC, Lambe M, Trichopoulos D, Leon D, Persson I, Ekbom A, Janson PO. Parity, age at first childbirth and risk of ovarian cancer. Lancet 1994; 344: 1250-4.
14. La Vecchia C, Franceschi S. Oral contraceptives and ovarian cancer. Eur J Cancer Prev 1999; 8: 297-304.
15. Westhoff C, Britton JA, Gammon MD, Wright T, Kelsey JL. Oral contraceptive and benign ovarian tumors. Am J Epidemiol 2000; 152: 242-6.
16. Garg PP, Kerlikowske K, Subak L, Grady D. Hormonal replacement therapy and risk of epithelial ovarian carcinoma: a meta-analysis. Obstet Gynecol 1998; 92: 472-9.
17. Rodriguez C, Patel AV, Calle EE, Jacobs EJ, Chao A, Thun MJ. Estrogen replacement therapy and mortality in large prospective study of US women. JAMA 2001; 285: 1460-5.
18. Abrahamsson G, Janson PO, Kullander S. Steroid release from two human epithelial tumors: evidence for an intrinsic production in vitro. Gynecol Oncol 1997; 64: 99-104.
19. Sasano H, Okamoto M, Mason JI, Simpson ER, Mendelson CR, Sasano N, Silverberg SG. Immunohistochemical studies of steroidogenic enzymes (aromatase, 17α-hydroxylases and cholesterol side-chain cleavage cytochromes P-450) in sex cord-stromal tumors of the ovary. Human Pathol 1989; 5: 452-7.
20. Sasano H, Mason JI, Sasaki E, Yajima A, Kimura N, Namiki T, Sasano N, Nagura H. Immunohistochemical study of 3β-hydroxysteroid dehydrogenase in sex cord-stromal tumors of the ovary. Int J Gynecol Pathol 1990; 9: 352-62.
21. Sugawara T, Lin D, Hoolt J, Martin KO, Javitt NB, Miller WL, Strauss JF 3rd. Structure of the human steroidogenic acute regulatory protein (StAR) gene: StAR stimulates mitochondrial cholesterol 27-hydroxylase activity. Biochemistry 1995; 34: 12506-12.
22. Clark BJ, Wells J, King SR, Stocco DM. The purification, cloning and expression of a novel luteinizing hormone- induced mitochondrial protein in MA-10 mouse leydig tumor cells. J Biol Chem 1994; 269: 28314-22.
23. Lin D, Sugawara T, Strauss JF 3rd, Clark BJ, Stocco DM, Saenger P, Rogol A, Miller WL. Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis. Science 1995; 267: 1828-31.
24. Stocco DM, Clark BJ. Regulation of acute production of steroid in steroidogenic tissue. Endocrine Rev 1996; 17: 221-44.
25. Ikeda Y, Swain A, Weber TJ, Hentges KE, Zanaria E, Lalli E, Tamai KT, Sassone-Corsi P, Lovell-Badge R, Camerino G, Parker KL. Steroidogenic factor 1 and DAX-1 colocalize in multiple cell lineages: potential links in endocrine development. Mol Endocrinol 1996; 10: 1261-72.
26. Lalli E, Melner MH, Stocco DM, Sassone-Corsi P. DAX-1 blocks steroid production at multiple levels. Endocrinology 1998; 139 (10): 4237-43.
27. Takayama K, Sasano H, Fukaya T, Morohashi K, Suzuki T, Tamura M, Costa MJ, Yajima A. Immunohistochemical localization of Ad4-binding protein with correlation to steroidogenic enzyme expression in cycling human ovaries and sex cord stromal tumors. J Clin Endocrinol Metab 1995; 80 (9): 2815-21.
28. Silverberg SG. Histological grading of ovarian carcinoma: a review and proposal. Int J Gynecol Pathol 2000; 19: 7-15.
29. McCarty KS, Miller LS, Cox EB, Konrath J, McCarty KS. Estrogen receptor analyses: Correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies. Arch Pathol Laboratory Med 1985; 109: 716-21.
30. Suzuki T, Takahashi K, Darnel AD, Moriya T, Murakami O, Narasaka T, Takayama J, Sasano H. Chicken ovalbumin upstream promoter transcription factor II in the human adrenal cortex and its disorders. J Clin Endocrinol Metab 2000; 85: 2752-7.
31. Gurates B, Sebastian S, Yang S, Zhou J, Tamura M, Fang Z, Suzuki T, Sasano H, Bulun SE. WT1 and DAX-1 inhibit Aromatase P450 expression in human endometrial and endometriotic stromal cells. J Clin Endocrinol Metab 2002; 87: 4369-77.
32. Abd-Elaziz M, Akahira JI, Moriya T, Suzuki T, Sasano H. A nuclear receptor DAX-1 in human common epithelial ovarian carcinoma: an independent prognostic factor of clinical outcome. Cancer Sci 2003; 94: 980-5.
33. Sato Y, Suzuki T, Hidaka K, Sato H, Ito K, Ito S, Sasano H. Immuno-localization of nuclear transcription factor, DAX-1 and COUP-TF II in the normal human ovary: Correlation with Ad4 BP/SF-1 immuno-localization during the menstrual cycle. J Clin Endocrinol Metab 2003; 88: 3415-20.
34. Okamura H, Katabuchi H, Ohba T. What we have learned from isolated cells from human ovary? Mol Cellular Endocrinol 2003; 202: 37-45.
35. Hamilton TC. Ovarian cancer, Part I: Biology. Curr Probl Cancer 1992; 16 (1): 1-57.
36. Syed V, Ho S. Progesterone induced apoptosis in immortalized normal and malignant human ovarian surface epithelial cells involves enhanced expression of Fasl Oncogene 2003; 22: 6883-90.
37. Lindgren PR, Backstrom T, Cajander S, Damber MG, Mahlck CG, Zhu D, Olofsson JI. The pattern of estradiol and progesterone differs in serum and tissue of benign and malignant ovarian tumors. Int J Oncol 2002; 21: 583-9.
38. Abd-Elaziz M, Moriya T, Akahira JI, Nakamura Y, Suzuki T, Sasano H. Immuno-localization of nuclear transcription factors, DAX-1 arid Ad4BP/SF-1 in human common epithelial ovarian tumors: correlations with StAR and steroidogenic enzymes in epithelial ovarian carcinoma. Int J Gynecol Pathol 2005; in press:.
39. Sasano H, Harada N. Intratumoral Aromatase in human breast, endometrial and ovarian malignancies. Endocrine Rev 1998; 19: 593-607.
40. Kaga K, Sasano H, Harada N, Ozaki M, Sato S, Yajima A. Aromatase in human common epithelial ovarian neoplasms. Am J Pathol 1996; 149: 45-51.
41. Imai A, Ohno T, Takahashi K, Furui T, Tamaya T. Lack of evidence for aromatase, expression in human ovarian epithelial carcinoma. Ann Clin Biochem 1994; 31: 65-71.