Association of CDKN2A (p16)/CDKN2B (p15) alterations and homozygous chromosome arm 9p deletions in human lung carcinoma

Genes Chromosomes and Cancer

Volumn 22, Issue 3, 1998, Pages 232-240

  Hamada, Kunihiro ^a,b   Kohno, Takashi ^a   Kawanishi, Masashi ^a   Ohwada, Susumu ^b   Yokota, Jun ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME 9P; CHROMOSOME ARM; CHROMOSOME DELETION; GENE ACTIVATION; GENE FREQUENCY; GENE MAPPING; GENE MUTATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; LUNG CARCINOGENESIS; LUNG CARCINOMA; METHYLATION; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

CARCINOMA, SMALL CELL; CARRIER PROTEINS; CELL CYCLE PROTEINS; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 9; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P16; HOMOZYGOTE; HUMANS; LOSS OF HETEROZYGOSITY; LUNG NEOPLASMS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0031776706     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2264(199807)22:3<232::AID-GCC9>3.0.CO;2-X     Document Type: Article

References (35)

1. INK4A gene. Int J Oncol 10:33-39.
2. Cairns P, Polascik TJ, Eby Y, Tokino K, Califano J, Merlo A, Mao L, Herath J, Jenkins R, Westra W, Rutter JL, Buckler A, Gabrielson E, Tockman M, Cho KR, Hedrick L, Bova GS, Issacs W, Koch W, Schwab D, Sidransky D (1995) Frequency of homozygous deletion at p16/CDKN2 in primary human tumours. Nat Genet 11:210-212.
3. Farrell WE, Simpson DJ, Bicknell JE, Talbot AJ, Bates AS, Clayton RN (1997) Chromosome 9p deletions in invasive and noninvasive nonfunctional pituitary adenomas: The deleted region involves markers outside of the MTS1 and MTS2 genes. Cancer Res 57:2703-2709.
4. INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature 371:257-261.
5. Herman JG, Merlo A, Mao L, Lapidus RG, Issa JJ, Davidson NE, Sidransky D, Baylin SB (1995) Inactivation of the CDKN2/p16/ MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 55:4525-4530.
6. INK4B1 Cancer Res 56:722-727.
7. INK4 gene mediated by an adenovirus vector. Cancer Res 55:3250-3253.
8. Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, Tavtigian SV, Stockert E, Day III RS, Johnson BE, Skolnik MH (1994) A cell cycle regulator potentially involved in genesis of many tumor types. Science 264:436-440.
9. Kawanishi M, Kohno T, Otsuka T, Adachi J, Sone S, Noguchi M, Hirohashi S, Yokota J (1997) Allelotype and replication error phenotype of small cell lung carcinoma. Carcinogenesis 18:2057-2062.
10. Kelly MJ, Nakagawa K, Steinberg SM, Mulshine JL, Kamb A, Johnson BE (1995) Differential inactivation of CDKN2 and RB protein in non-small cell and small cell lung cancer cell lines. J Natl Cancer Inst 87:756-761.
11. Kim SK, Ro JY, Kemp BL, Lee JS, Kwon TJ, Fong KM, Sekido Y, Minna JD, Hong WK, Mao L (1997) Identification of three distinct tumor suppressor loci on the short arm of chromosome 9 in small cell lung cancer. Cancer Res 57:400-403.
12. Kohno T, Otuka T, Takano H, Yamamoto T, Hamaguchi M, Terada M, Yokota J (1995) Identification of a novel phospholipase C family gene at chromosome 2q33 that is homozygously deleted in human small cell lung carcinoma. Hum Mol Genet 4:667-674.
13. Li Y, Hoang-Xuan K, Delattre J, Poisson M, Thomas G, Hamelin R (1995) Frequent loss of heterozygosity on chromosome 9, and low incidence of mutations of cyclin-dependent kinase inhibitors p15 (MTS2) and p16 (MTS1) genes in gliomas. Oncogene 11:597-600.
14. Maniatis T, Fritsch FF, Sambrook J (1982) Moleqular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
15. Mead LJ, Gillespie MT, Hung JY, Rane US, Rayeroux KC, Irving LB, Campbell LJ (1997) Frequent loss of heterozygosity in early non-small cell lung cancers at chromosome 9p21 proximal to the CDKN2A gene. Int J Cancer 71:213-217.
16. Merlo A, Gabrielson E, Askin F, Sidransky D (1994a) Frequent loss of chromosome 9 in human primary non-small cell lung cancer. Cancer Res 54:640-642.
17. Merlo A, Gabrielson E, Mabry M, Vollmer R, Baylin SB, Sidransky D (1994b) Homozygous deletion on chromosome 9p and loss of heterozygosity on 9q, 6p, and 6q in primary human small cell lung cancer. Cancer Res 54:2322-2326.
18. Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson K, Burger PC, Baylin SB, Sidransky D (1995) 5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1:686-692.
19. Nakagawa K, Conrad NK, Williams JP, Johnson BE, Kelly MJ (1995) Mechanism of inactivation of CDKN2 and MTS2 in non-small cell lung cancer and association with advanced stage. Oncogene 11:1843-1851.
20. Neville EM, Stewart M, Myskow M, Donnelly RJ, Field JK (1995) Loss of heterozygosity at 9p23 defines a novel locus in non-small cell lung cancer. Oncogene 11:581-585.
21. Nobori T, Miura K, Wu DJ, Lois A, Takabayasi K, Carson DA (1994) Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 368:753-756.
22. Ohta M, Berd D, Shimizu M, Nagai H, Cotticelli M, Mastrangelo M, Shields JA, Shields CL, Croce CM, Huebner K (1996) Deletion mapping of chromosome region 9p21-p22 surrounding the CDKN2 locus in melanoma. Int J Cancer 65:762-767.
23. INk4B/MTS2, and p18 genes in primary and metastatic lung cancer. Cancer Res 55:1448-1451.
24. INK4 protein is restricted to the subset of lung cancer lines that retains wild-type RB. Oncogene 9:3375-3378.
25. Puig S, Ruiz A, Lazaro C, Castel T, Lynch M, Palou J, Vilalta A, Weissenbach J, Mascaro J, Estivill X (1995) Chromosome 9p deletions in cutaneous malignant melanoma tumors: The minimal deleted region involves markers outside the p16 (CDKN2) gene. Am J Hum Genet 57:395-402.
26. Rodabaugh KJ, Biggs RB, Qureshi JA, Barrett AJ, Welch WR, Bell DA, Berkowitz RS, Mok SC (1995) Detailed deletion mapping of chromosome 9p and p16 gene alterations in human borderline and invasive epithelial ovarian tumors. Oncogene 11:1249-1254.
27. INK4B and p18 genes in primary non-small cell lung cancers. Int J Cancer 65:734-739.
28. INK4A inactivation in non-small cell lung cancer cell lines. Cancer Res 55:6200-6209.
29. Shimizu T, Sekiya T (1995) Loss of heterozygosity at 9p21 loci and mutations of the MTS1 and MTS2 genes in human lung cancers. Int J Cancer 63:616-620.
30. Shiseki M, Kohno T, Adachi J, Okazaki T, Otsuka T, Mizoguchi H, Noguchi M, Hirohashi S, Yokota J (1996) Comparative allelotype of early and advanced stage non-small cell lung carcinomas. Genes Chromosomes Cancer 17:71-77.
31. Takita J, Hayashi Y, Kohno T, Yamaguchi N, Hanada R, Yamamoto K, Yokota J (1997) Deletion map of chromosome 9 and p16 (CDKN2A) gene alterations in neuroblastoma. Cancer Res 57:907-912.
32. Washimi O, Nagatake M, Osada H, Ueda R, Koshikawa T, Seki T, Takahashi T, Takahashi T (1995) In vivo occurrence of p16 (MTS1) andp15 (MTS2) alterations preferentially in non-small cell lung cancers. Cancer Res 55:514-517.
33. Wiest JS, Franklin WA, Otstot JT, Forbey K, Varella-Garcia M, Rao K, Drabkin H, Gemmill R, Ahrent S, Sidransky D, Saccomanno G, Fountain JW, Anderson MW (1997) Identification of a novel region of homozygous deletion on chromosome 9p in squamous cell carcinoma of the lung: The location of a putative tumor suppressor gene. Cancer Res 57:1-6.
34. Xiao S, Li D, Corson JM, Vijg J, Fletcher JA (1995) Codeletion of p15 and p16 genes in primary non-small cell lung carcinoma. Cancer Res 55:2968-2971.
35. Yokota J, Akiyama T, Fung YKT, Benedict WF, Namba Y, Hanaoka M, Wada M, Terasaki T, Shimosato Y, Sugimura T, Terada M (1988) Altered expression of the retinoblastoma (RB) gene in small cell carcinoma of the lung. Oncogene 3:471-475.