Intraperitoneal injection of adenovirus expressing antisense K-ras RNA suppresses peritoneal dissemination of hamster syngeneic pancreatic cancer without systemic toxicity

Cancer Letters

Volumn 218, Issue 1, 2005, Pages 53-62

  Miura, Yoshiaki ^a   Ohnami, Shumpei ^a   Yoshida, Kimiko ^a   Ohashi, Masaki ^a   Nakano, Masaru ^a   Ohnami, Sumiko ^a   Fukuhara, Munehisa ^b   Yanagi, Ken ^b   Matsushita, Akira ^b   Uchida, Eiji ^b   Asaka, Masahiro ^c   Yoshida, Teruhiko ^a   Aoki, Kazunori ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

^c HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Adenovirus; Antisense K ras; Pancreatic cancer; Peritoneal dissemination

Indexed keywords

ADENOVIRUS VECTOR; COMPLEMENTARY RNA; K RAS PROTEIN; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CONTROLLED STUDY; CORRELATION ANALYSIS; DISSEMINATED CANCER; DRUG EFFECT; DRUG SAFETY; GENE CONSTRUCT; GENE EXPRESSION; GENE INDUCTION; HAMSTER; HUMAN; HUMAN CELL; INJECTION; NONHUMAN; ONCOGENE K RAS; PANCREAS CANCER; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

ADENOVIRIDAE; ANIMALS; CRICETINAE; GENE THERAPY; GENES, RAS; HUMANS; INJECTIONS, INTRAPERITONEAL; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; PANCREATIC NEOPLASMS; PERITONEAL NEOPLASMS; RNA; RNA, ANTISENSE; TRANSDUCTION, GENETIC; TUMOR CELLS, CULTURED;

ADENOVIRIDAE; CRICETINAE; MUS MUSCULUS;

EID: 19944428405     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2004.08.015     Document Type: Article

References (33)

1. D.G. Haller Future directions in the treatment of pancreatic cancer Semin. Oncol. 29 2002 31 39
2. D.P. Ryan, and C.G. Willett Management of locally advanced adenocarcinoma of the pancreas Hematol. Oncol. Clin. North Am. 16 2002 95 103
3. H.L. Kaufman, J. DiVito, and H. Horig Immunotherapy for pancreatic cancer: current concepts Hematol. Oncol. Clin. North Am. 16 2002 159 197
4. T. Yoshida, S. Ohnami, and K. Aoki Development of gene therapy to target pancreatic cancer Cancer Sci. 95 2004 283 289
5. G.H. Sakorafas, A.G. Tsiotou, and G.G. Tsiotos Molecular biology of pancreatic cancer; oncogenes, tumour suppressor genes, growth factors, and their receptors from a clinical perspective Cancer Treat. Rev. 26 2000 29 52
6. K. Motojima, T. Urano, Y. Nagata, H. Shiku, T. Tsunoda, and T. Kanematsu Mutations in the Kirsten-ras oncogene are common but lack correlation with prognosis and tumor stage in human pancreatic carcinoma Am. J. Gastroenterol. 86 1991 1784 1788
7. J.A. DiGiuseppe, R.H. Hruban, G.J. Offerhaus, M.J. Clement, F.M. van den Berg, J.L. Cameron, and A.D. van Mansfeld Detection of K-ras mutations in mucinous pancreatic duct hyperplasia from a patient with a family history of pancreatic carcinoma Am. J. Pathol. 144 1994 889 895
8. W.L. Cerny, K.A. Mangold, and D.G. Scarpelli K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster Cancer Res. 52 1992 4507 4513
9. A. Yanagisawa, K. Ohtake, K. Ohashi, M. Hori, T. Kitagawa, and H. Sugano Frequent c-Ki-ras oncogene activation in mucous cell hyperplasias of pancreas suffering from chronic inflammation Cancer Res. 53 1993 953 956
10. K. Aoki, T. Yoshida, T. Sugimura, and M. Terada Liposome-mediated in vivo gene transfer of antisense K-ras construct inhibits pancreatic tumor dissemination in the murine peritoneal cavity Cancer Res. 55 1995 3810 3816
11. K. Aoki, T. Yoshida, N. Matsumoto, H. Ide, T. Sugimura, and M. Terada Suppression of Ki-ras p21 levels leading to growth inhibition of pancreatic cancer cell lines with Ki-ras mutation but not those without Ki-ras mutation Mol. Carcinog. 20 1997 251 258
12. K. Kita, S. Saito, C.Y. Morioka, and A. Watanabe Growth inhibition of human pancreatic cancer cell lines by anti-sense oligonucleotides specific to mutated K-ras genes Int. J. Cancer 80 1999 553 558
13. J.A. Roth, T. Mukhopadhyay, W.W. Zhang, T. Fujiwara, and R. Georges Gene replacement strategies for lung cancer Semin. Radiat. Oncol. 6 1996 105 109
14. Y.A. Zhang, J. Nemunaitis, and A.W. Tong Generation of a ribozyme-adenoviral vector against K-ras mutant human lung cancer cells Mol. Biotechnol. 15 2000 39 49
15. J.J. Song, H. Lee, E. Kim, Y.S. Kim, N.C. Yoo, and J.K. Roh Transduction effect of antisense K-ras on malignant phenotypes in gastric cancer cells Cancer Lett. 157 2000 1 7
16. M. Nakano, K. Aoki, N. Matsumoto, S. Ohnami, K. Hatanaka, and T. Hibi Suppression of colorectal cancer growth using an adenovirus vector expressing an antisense K-ras RNA Mol. Ther. 3 2001 491 499
17. R.D. Alvarez, J. Gomez-Navarro, M. Wang, M.N. Barnes, T.V. Strong, and R.B. Arani Adenoviral-mediated suicide gene therapy for ovarian cancer Mol. Ther. 2 2000 524 530
18. A. Hasenburg, X.W. Tong, A. Rojas-Martinez, C. Nyberg-Hoffman, C.C. Kieback, and A. Kaplan Thymidine kinase gene therapy with concomitant topotecan chemotherapy for recurrent ovarian cancer Cancer Gene Ther. 7 2000 839 844
19. K. Yanagi, M. Onda, and E. Uchida Effect of angiostatin on liver metastasis of pancreatic cancer in hamsters Jpn. J. Cancer. Res. 91 2000 723 730
20. K. Suzuki, K. Aoki, S. Ohnami, K. Yoshida, T. Kazui, and N. Kato Adenovirus-mediated gene transfer of interferon alpha improves dimethylnitrosamine-induced liver cirrhosis in rat model Gene Therapy 10 2003 765 773
21. K. Aoki, C. Barker, X. Danthinne, M.J. Imperiale, and G.J. Nabel Efficient generation of recombinant adenoviral vectors by Cre-lox recombination in vitro Mol. Med. 5 1999 224 231
22. H. Niwa, K. Yamamura, and J. Miyazaki Efficient selection for high-expression transfectants with a novel eukaryotic vector Gene 108 1991 193 199
23. S. Ohnami, K. Aoki, K. Yoshida, K. Hatanaka, K. Suzuki, and H. Sasaki Expression profiles of pancreatic cancer cell lines infected with antisense K-ras-expressing adenoviral vector Biochem. Biophys. Res. Commun. 309 2003 798 803
24. I.B. Weinstein Cancer. Addiction to oncogenes - the Achilles heal of cancer Science 297 2002 63 64
25. K. Aoki, S. Furuhata, K. Hatanaka, M. Maeda, J.S. Remy, and J.P. Behr Polyethylenimine-mediated gene transfer into pancreatic tumor dissemination in the murine peritoneal cavity Gene Therapy 8 2001 508 514
26. A.D. Cox, and C.J. Der The dark side of ras: regulation of apoptosis Oncogene 22 2003 8999 9006
27. T. Tsuchida, H. Kijima, S. Hori, Y. Oshika, T. Tokunaga, and K. Kawai Adenovirus-mediated anti-K-ras ribozyme induces apoptosis and growth suppression of human pancreatic carcinoma Cancer Gene Ther. 7 2000 373 383
28. M. Saimura, E. Nagai, K. Mizumoto, N. Maehara, H. Okino, and M. Katano Intraperitoneal injection of adenovirus-mediated NK4 gene suppresses peritoneal dissemination of pancreatic cancer cell line AsPC-1 in nude mice Cancer Gene Ther. 9 2002 799 806
29. K. Aoki, T. Yoshida, N. Matsumoto, H. Ide, K. Hosokawa, T. Sugimura, and M. Terada Gene therapy for peritoneal dissemination of pancreatic cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene Hum. Gene Ther. 8 1997 1105 1113
30. H. Kasuya, Y. Nishiyama, S. Nomoto, J. Hosono, S. Takeda, and A. Nakao Intraperitoneal delivery of hrR3 and ganciclovir prolongs survival in mice with disseminated pancreatic cancer J. Surg. Oncol. 72 1999 136 141
31. M. Oonuma, M. Sunamura, F. Motoi, S. Fukuyama, H. Shimamura, and J. Yamauchi Gene therapy for intraperitoneally disseminated pancreatic cancers by Escherichia coli uracil phosphoribosiltransferase (UPRT) gene mediated by restricted replication-competent adenoviral vectors Int. J. Cancer 102 2002 51 59
32. A. Hajri, S. Wack, P. Lehn, J.P. Vigneron, J.M. Lehn, J. Marescaux, and M. Aprahamian Combined suicide gene therapy for pancreatic peritoneal carcinomatosis using BGTC liposomes Cancer Gene Ther. 11 2004 16 27
33. C. Volpers, and S. Kochanek Adenoviral vectors for gene transfer and therapy J. Gene Med. 6 Suppl. 1 2004 S164 S171