Intraperitoneal delivery of hrR3 and ganciclovir prolongs survival in mice with disseminated pancreatic cancer

Journal of Surgical Oncology

Volumn 72, Issue 3, 1999, Pages 136-141

  Kasuya, Hideki ^a   Nishiyama, Yukihiro ^a   Nomoto, Shuji ^a   Hosono, Jiro ^a   Takeda, Shin ^a   Nakao, Akimasa ^a,b  

^a Department of Breast and Endocrine Surgery Aichi Medical School of Medicine   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Disseminated pancreatic cancer; Ganciclovir; Herpes vector; HrR3; Intraperitoneal delivery

Indexed keywords

GANCICLOVIR; RIBONUCLEOTIDE REDUCTASE; VIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; GENE THERAPY; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; METASTASIS; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; VIRUS REPLICATION;

ANIMALS; FEMALE; GANCICLOVIR; GENE THERAPY; GENETIC VECTORS; HUMANS; INJECTIONS, INTRAPERITONEAL; MICE; MICE, INBRED BALB C; NEOPLASM TRANSPLANTATION; PANCREATIC NEOPLASMS; RIBONUCLEOTIDE REDUCTASES; SIMPLEXVIRUS; THYMIDINE KINASE; TRANSPLANTATION, HETEROLOGOUS;

EID: 0032756916     PISSN: 00224790     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9098(199911)72:3<136::AID-JSO5>3.0.CO;2-3     Document Type: Article

References (17)

1. Warshaw AL, Fernandez-del Castillo C: Pancreatic carcinoma. N Engl J Med 1992;326:455-465.
2. Yamaguti K, Enjoji M: Carcinoma of the pancreas, A clinicopathologic study of 96 cases with immunohistochemical observations. Jpn J Clin Oncol 1989;19:14-22.
3. Westerdahl J, Andren-Sandberg A: Recurrence of exocrine pancreatic cancer-local or hepatic? Hepatogastroenterology 1993;40: 384-387.
4. Kayahara M, Nagakawa T, Ueno K: An evaluation of radical resection for pancreatic cancer based on the mode of recurrence as determined by autopsy and diagnostic imaging. Cancer 1993;72: 2118-2123.
5. Dobelbower RR, Bronn DG: Radiotherapy in the treatment of pancreatic cancer. Bailliere Clin Gastroenterol 1990;4:969-983.
6. Arbuck SG: Overview of chemotherapy for pancreatic cancer. Int J Pancreatol 1990;7:209-222.
7. Hammel W, Magnelli L, Chiarugi VP: Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells. Cancer Res 1996;56:2697-2702.
8. Sawada T, Ho JJL, Chung Y-S, et al.: Stimulation of cellular motility by factor(s) released by SW1990 pancreatic cancer cells [abstract]. Gastroenterology 1993;104:A334.
9. Hosono J, Kasai Y, Nonami T, Nakao A, Takagi H: Involvement of adhesion molecules in metastasis of SW1990, human pancreatic cancer cells. J Surg Oncol 1998;67:77-84.
10. Goldstein DJ, Weller SK: Factor(s) present in herpes simplex virus type 1-infected cells can compensate for the loss of the large subunit of the viral ribonucleotide reductase: characterization of an ICP6 deletion mutant. Virology 1988;166:41-51.
11. Boviatsis EJ, Chase M, Wei M, Tamiya T: Gene transfer into experimental brain tumors mediated by adenovirus, herpes simplex virus (HSV), and retrovirus vectors. Hum Gene Ther 1994a;5:183-191.
12. Martuza RL, Malick A, Markert JM: Experimental therapy of a genetically engineered virus mutant. Science 1991;252:854-856.
13. Yamada Y, Nishiyama Y: The pathogenicity of ribonucleotide reductase null mutants of herpes simplex virus type 1 in mice. J Infect Dis 1991;164:1091-1097.
14. Yang L, Hwang R, Pandit L: Gene therapy of metastatic pancreas cancer with intraperitoneal injections of concentrated retroviral herpes simplex thymidine kinase vector supernatant and ganciclovir. Ann Surg 1996;224:405-414.
15. Hwang RF, Gordon EM, Anderson WF, Parekh D: Gene therapy for primary and metastatic pancreatic cancer with intraperitoneal retroviral vector bearing the wild-type p53. Surgery 1998;124: 143-150.
16. Aoki K, Yoshida T, Matsumoto N, et al.: Gene therapy for peritoneal dissemination of pancreatic cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene. Hum Gene Ther 1997;8:1105-1113.
17. Christof MK, Nikolai GR, Miguel SE: Long-term survival in a rodent model of disseminated brain tumors by combined intrathecal delivery of herpes vectors and ganciclovir treatment. Hum Gene Therapy 1996;7:1989-1994.