Targeting exosites on blood coagulation proteases

Anais da Academia Brasileira de Ciencias

Volumn 77, Issue 2, 2005, Pages 275-280

  Monteiro, Robson Q ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Blood coagulation; Exogenous inhibitors; Exosites; Serine proteases

Indexed keywords

ACARI; SERPENTES;

EID: 19844383838     PISSN: 00013765     EISSN: None     Source Type: Journal    
DOI: 10.1590/s0001-37652005000200007     Document Type: Review

References (28)

1. ANDERSON PJ, NESSET A, DHARMAWARDANA KR AND BOCK PE. 2000a. Characterization of proexosite I on prothrombin. J Biol Chem 275: 16428-16434.
2. ANDERSON PJ, NESSET A, DHARMAWARDANA KR AND BOCK PE. 2000b. Role of proexosite I in factor Va-dependent substrate interactions of prothrombin activation. J Biol Chem 275: 16435-16442.
3. AROCAS V, ZINGALI RB, GUILLIN MC, BON C AND JANDROT-PERRUS M. 1996. Bothrojaracin: a potent two-site-directed thrombin inhibitor. Biochemistry 35: 9083-9089.
4. BANNER DW, D'ARCY A, CHENE C, WINKLER FK, GUHA A, KONIGSBERG WH, NEMERSON Y AND KIRCHHOFER D. 1996. The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. Nature 380: 41-46.
5. BODE W, MAYR I, BAUMANN U, HUBER R, STONE SR AND HOFSTEENGE J. 1989. The refined 1.9 Å crystal structure of human-thrombin: interaction with D Phe Pro Arg chloromethylketone and significance of the Tyr Pro Pro Trp insertion segment. EMBO J 8: 3467-3475.
6. BODE W, BRANDSTETTER H, MATHER T AND STUBBS MT. 1997. Comparative analysis of haemostatic proteinases: structural aspects of thrombin, factor Xa, factor IXa and protein C. Thromb Haemost 78: 501-511.
7. CHEN L, YANG L AND REZAIE AR. 2003. Proexosite-1 on prothrombin is a factor Va-dependent recognition site for the prothrombinase complex. J Biol Chem 278: 27564-27569.
8. FENTON JW 2ND, OLSON TA, ZABINSKI MP AND WILNER GD. 1988. Anion-binding exosite of human alphathrombin and fibrin(ogen) recognition. Biochemistry 27: 7106-7112.
9. FRANCISCHETTI IM, VALENZUELA JG, ANDERSEN JF, MATHER TN AND RIBEIRO JM. 2002. Ixolaris, a novel recombinant tissue factor pathway inhibitor (TFPI) from the salivary gland of the tick, Ixodes scapularis: identification of factor X and factor Xa as scaffolds for the inhibition of factor Vila/tissue factor complex. Blood 99: 3602-3612.
10. KRISHNASWAMY S. 2005. Exosite-driven substrate specificity and function in coagulation. J Thromb Haemost 3: 54-67.
11. KRSTENANSKY JL AND MAO SJT. 1987. Antithrombin properties of C-terminus of hirudin using synthetic unsulfated N-alpha-acetyl-hirudin45-65. FEBS Lett 211: 10-16.
12. LIU LW, VU TKH, ESMON CT AND COUGHLIN SR. 1991. The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity. J Biol Chem 266: 16977-16980.
13. MANN KG. 1999. Biochemistry and physiology of blood coagulation. Thromb Haemost 82: 165-174.
14. MARKLAND FS. 1998. Snake venoms and the hemostatic system. Toxicon 36: 1749-1800.
15. MONTEIRO RQ AND ZINGALI RB. 2002. Bothrojaracin, a proexosite I ligand, inhibits factor Va-accelerated prothrombin activation. Thromb Haemost 87: 288-293.
16. MONTEIRO RQ, RAPOSO JG, WISNER A, GUIMARAES JA, BON C AND ZINGALI RB. 1999. Allosteric changes of thrombin catalytic site induced by interaction of bothrojaracin with anion-binding exosites I and II. Biochem Biophys Res Commun 262: 819-822.
17. MONTEIRO RQ, BOCK PE, BIANCONI ML AND ZINGALI RB. 2001. Characterization of bothrojaracin interaction with human prothrombin. Protein Sci 10: 1897-1904.
18. MONTEIRO RQ, REZAIE AR, RIBEIRO JMC AND FRANCISCHETTI IM. 2005. Ixolaris: a factor Xa heparinbinding exosite inhibitor. Biochem J (in press).
19. NASKI MC, FENTON JW 2ND, MARAGANORE JM, OLSON ST AND SHAFER JA. 1990. The COOH-terminal domain of hirudin. An exosite-directed competitive inhibitor of the action of alpha-thrombin on fibrinogen. J Biol Chem 265: 13484-13489.
20. NOGAMI K, FREAS J, MANITHODY C, WAKABAYASHI H, REZAIE AR AND FAY PJ. 2004. Mechanisms of interactions of factor X and factor Xa with the acidic region in the factor VIII A1 domain. J Biol Chem 279: 33104-33113.
21. PADMANABHAN K, PADMANABHAN KP, TULINSKY A, PARK CH, BODE W, HUBER R, BLANKENSHIP DT, CARDIN AD AND KISIEL W. 1993. Structure of human des(1-45) factor Xa at 2.2 Å resolution. J Mol Biol 232: 947-996.
22. REZAIE AR. 2000. Identification of basic residues in the heparin binding exosite of factor Xa critical for heparin and factor Va binding. J Biol Chem 275: 3320-3327.
23. RIBEIRO JMC AND FRANCISCHETTI IMB. 2003. Role of arthropod saliva in blood feeding: sialome and post sialome perspectives. Ann Rev Entomol 48: 73-88.
24. ROSE T AND DI CERA E. 2002. Substrate recognition drives the evolution of serine proteases. J Biol Chem 277: 19243-19246.
25. ROSING J, TANS G, COVERS RIEMSLAG JW, ZWAAL RF AND HEMKER HC. 1980. The role of phospholipids and factor Va in the prothrombinase complex. J Biol Chem 25: 274-283.
26. SHEEHAN JP AND SADLER JE. 1994. Molecular mapping of the heparin binding exosite of thrombin. Proc Natl Acad Sci USA 91: 5518-5522.
27. YANG L, MANITHODY C AND REZAIE AR. 2002. Localization of the heparin binding exosite of factor IXa. J Biol Chem 272: 50756-50760.
28. ZINGALI RB, JANDROT-PERRUS M, GUILLIN MC AND BON C. 1993. Bothrojaracin, a new thrombin inhibitor isolated from Bothrops jararaca venom: characterization and mechanism of thrombin inhibition. Biochemistry 32: 10794-10802.