Depressed diabetics: A neuroimmunologic syndrome?

Primary Psychiatry

Volumn 12, Issue 5, 2005, Pages 42-46

  Sabharwal, Pooja ^a   Simen, Birgitte Binderup ^a   Sanacora, Gerard ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Yale University School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; AMPA RECEPTOR; AUTOANTIBODY; CYTOKINE; GLUTAMATE DECARBOXYLASE ANTIBODY; INTERFERON; SEROTONIN; TRYPTOPHAN; TUMOR NECROSIS FACTOR;

CENTRAL NERVOUS SYSTEM; COMORBIDITY; DEPRESSION; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; HOST RESISTANCE; HUMAN; HYPERGLYCEMIA; IMMUNE SYSTEM; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR DEPRESSION; MORBIDITY; NEUROIMMUNOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; PREVALENCE; PSYCHOPHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

EID: 19644396614     PISSN: 10826319     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (41)

1. Harris MI, Flegal KM, Cowie CC, et al. Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988-1994. Diabetes Care. 1998;21(4):518-524.
2. Borg H, Marcus C, Sjoblad S, et al. Islet cell antibody frequency differs from that of glutamic acid decarboxylase antibodies/IA2 antibodies after diagnosis of diabetes. Acta Paediatr. 2000;89(1):46-51.
3. Mitka M. Metabolic syndrome recasts old cardiac, diabetes risk factors as a "new" entity. JAMA. 2004;291(17):2062-2063.
4. Lustman PJ, douse RE, Freedland KE. Management of major depression in adults with diabetes: implications of recent clinical trials. Semin Clin Neuropsychiatry. 1998;3(2):102-114.
5. Gavard JA, Lustman PJ, Clouse RE, Prevalence of depression in adults with diabetes. An epidemiological evaluation. Diabetes Care. 1993;16(8):1167-1178.
6. Anderson RJ, Freedland KE, Clouse RE, et al. The prevalence of comorbid depression in adults with diabetes: a meta-analysis. Diabetes Care. 2001;24(6):1069-1078.
7. Musselman DL, Betan E, Larsen H, et al. Relationship of depression to diabetes types 1 and 2: epidemiology, biology, and treatment. Biol Psychiatry. 2003;54(3):317-329.
8. Popkin MK, Callies AL, Lentz RD, et al. Prevalence of major depression, simple phobia, and other psychiatric disorders in patients with long-standing type I diabetes mellitus. Arch Gen Psychiatry, 1988;45(1):64-68.
9. Kawakami N, Takatsuka N, Shimizu H, et al. Depressive symptoms and occurrence of type 2 diabetes among Japanese men. Diabetes Care. 1999;22(7):1071-1076.
10. Penninx BW, Kritchevsky SB, Yaffe K, et al. Inflammatory markers and depressed mood in older persons: results from the Health, Aging and Body Composition study. Biol Psychiatry. 2003;54(5):566-572.
11. Elenkov IJ, Chrousos GP. Stress, cytokine patterns and susceptibility to disease. Baillieres Best Pract Res Clin Endocrinol Metab. 1999;13(4):583-595.
12. Dantzer R. Cytokine-induced sickness behavior: mechanisms and implications. Ann N Y Acad Sci. 2001;933:222-234.
13. Capuron L, Dantzer R, Cytokines and depression: the need for a new paradigm. Brain Behav Immun. 2003;17(suppl 1):S119-S124.
14. Capuron L, Ravaud A, Dantzer R. Early depressive symptoms in cancer patients receiving interleukin 2 and/or interferon alfa-2b therapy. J Clin Oncol. 2000;18(10):2143-2151.
15. Beattie EC, Stellwagen D, Morishita W, et al. Control of synaptic strength by glial TNFalpha. Science. 2002;295(5563):2282-2285.
16. Monje ML, Toda H, Palmer TD. Inflammatory blockade restores adult hippocampal neurogenesis. Science. 2003;302(5651):1760-1765.
17. Maes M, Meltzer HY, Stevens W, et al. Natural killer cell activity in major depression: relation to circulating natural killer cells, cellular indices of the immune response. and depressive phenomenology. Prog Neuropsychopharmacol Biol Psychiatry. 1994;18(4):717-730.
18. Mikova O, Yakimova R, Bosmans E. et al. Increased serum tumor necrosis factor alpha concentrations in major depression and multiple sclerosis. Eur Neuropsychophamacol. 2001;11(3):203-208.
19. Lanquillon S, Krieg JC, Bening-Abu-Shach U, et al. Cytokine production and treatment response in major depressive disorder. Neuropsychopharmacology. 2000;22(4):370-379.
20. Kenis G, Maes M. Effects of antidepressants on the production of cytokines. Int J Neuropsychopharmacol. 2002;5(4):401-412.
21. Hussain MJ, Peakman M, Gallati H, et al. Elevated serum levels of macrophage-derived cytokines precede and accompany the onset of IDDM. Diabetologia. 1996;39(1):60-69.
22. Lechleitner M, Koch T, Herzold M, et al. Tumor necrosis factor-alpha plasma level in patients with type 1 diabetes mellitus and its association with glycaemic control and cardiovascular risk factors. J Internal Med. 2000;248(1):67-76.
23. Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care. 2004;27(3):813-823.
24. Sanacora G, Mason GF, Krystal JH. Impairment of GABAergic transmission in depression: new insights from neuroimaging studies. Crit Rev Neurobiol. 2000;14(1):23-45.
25. Brambilla P, Perez J, Barale F, et al. GABAergic dysfunction in mood disorders. Mol Psychiatry. 2003;8(8):721-737.
26. Erlander MG, Tillakaratne NJ, Feldblum S, et al. Two genes encode distinct glutamate decarboxylases. Neuron. 1991;7(1):91-100.
27. Dalakas MC, Fujii M, Li M, et al. The clinical spectrum of anti-GAD antibody-positive patients with stiff-person syndrome. Neurology. 2000;55(10):1531-1535.
28. Solimena M. De Camilli P. Autoimmunity to glutamic acid decarboxylase (GAD) in Stiff-Man syndrome and insulin-dependent diabetes mellitus. Trends Neurosci. 1991;14(10):452-457.
29. Dalakas MC, Li M, Fujii M, et al. Stiff person syndrome: quantification, specificity, and intrathecal synthesis of GAD65 antibodies. Neurology. 2001;57(5):780-784.
30. Black JL, Barth EM, Williams DE, et al. Stiff-man syndrome. Results of interviews and psychologic testing. Psychosomatics. 1998;39(1):38-44.
31. Kovacs M, Goldston D, Obrosky DS, et al. Psychiatric disorders in youths with IDDM: rates and risk factors. Diabetes Care. 1997;20(1):36-44.
32. Grey M, Cameron ME, Lipman TH, et al. Psychosocial status of children with diabetes in the first 2 years after diagnosis. Diabetes Care. 1995;18(10):1330-1336.
33. Sanacora G, Mason GF, Rothman DL, et al. Increased cortical GABA concentrations in depressed patients receiving ECT. Am J Psychiatry. 2003;160(3):577-579.
34. Sanacora G, Mason GF, Rothman DL, et al. Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors. Am J Psychiatry. 2002;159(4):663-665.
35. Padmos RC, Bekris L, Knijff EM, et al. A high prevalence of organ-specific autoimmunity in patients with bipolar disorder. Biol Psychiatry. 2004;56(7):476-482.
36. Aerts L, Van Assche FA. Low taurine, gamma-aminobutyric acid and carnosine levels in plasma of diabetic pregnant rats: consequences for the offspring. J Perinat Med. 2001;29(1):81-84.
37. Honda M, Inoue M, Okada Y, et al. Alteration of the GABAergic neuronal system of the retina and superior colliculus in streptozotocin-induced diabetic rat. Kobe J Med Sci. 1998;44(1):1-8.
38. Trimarchi GR, Squadrito F, Magri V, et al. Cerebral GABAergic control of arterial blood pressure and heart rate in diabetic rats. Res Commun Chem Pathol Pharmacol. 1987;58(3):307-321.
39. Gomez R, Vargas CR, Wajner M, et al. Lower in vivo brain extracellular GABA concentration in diabetic rats during Forced swimming. Brain Res. 2003;968(2):281-284.
40. Katon W, Ciechanowski P. Impact of major depression on chronic medical illness. J Psychosom Res. 2002;53(4):859-863.
41. Egede LE, Zheng D, Simpson K, Comorbid depression is associated with increased health care use and expenditures in individuals with diabetes. Diabetes Care. 2002;25(3):464-470.